Application of Gold(III) Acetate as a New Precursor for the Synthesis of Gold Nanoparticles in PEG Through Ultrasonic Spray Pyrolysis

Shariq, Mohammed; Majerič, Peter; Friedrich, Bernd; Budič, Bojan; Jenko, Darja; Dixit, Amit Rai; Rudolf, Rebeka

doi:10.1007/s10876-017-1178-0

Cited by 21 publications

(19 citation statements)

References 64 publications

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“…The lower surface tension affects the droplet formation by ultrasound, resulting in smaller droplets and consequently smaller AuNPs. Previously, we have shown comparisons between different precursor acids, such as the chlorides, acetates and nitrides used with USP [57,58]. However, the comparisons between different acidity levels of the same acid (chloride) have not yet been shown, nor are they readily available in literature.…”

Section: Tem Analysismentioning

confidence: 99%

Low-cost synthesis of AuNPs through ultrasonic spray pyrolysis

Tiyyagura

Majerič

Anžel

et al. 2020

Mater. Res. Express

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The present research informs about the synthesis of gold nanoparticles (AuNPs) through Ultrasonic Spray Pyrolysis (USP), which were collected in ethanol with 0.1% Polyvinylpyrrolidone (PVP). Initially, the research focused on two precursors, where the first represented a homemade H-HAuCl 4 , completed in our own laboratory through the chlorine gas method by using HCl and KMnO 4 , and the second was the commercial C-HAuCl 4 , prepared by using Gold (III) chloride tetrahydrate powder and deionised water. The goal was to find any potential precursor differences and their influences on the later use for AuNPs synthesis through USP using almost the same parameters. In the first step of research it was determined that the H-HAuCl 4 precursor was similar to C-HAuCl 4 in chemical composition, surface tension and pH value. This finding represented the starting point for being able to use H-HAuCl 4 in the USP for AuNPs' synthesis. In the second step, AuNPs were synthesised from both types of precursors. Afterwards, characterisation of some functional properties by FTIR and UVvis techniques was done directly for H-and C-AuNPs in the collecting media. For SEM/EDX and TEM microscopy both types of H-and C-AuNPs were dried, and observation revealed that the morphology, shape and size distribution of dried AuNPs were very similar. Based on the performed laboratory research, it could be concluded that prepared H-AuNPs could represent a new and lowcost effective solution for future USP transfer onto the industrial level, not only in in the process itself, but also in the field of Low-cost Precursor Preparation.Abbreviations

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Section: Tem Analysismentioning

confidence: 99%

Low-cost synthesis of AuNPs through ultrasonic spray pyrolysis

Tiyyagura

Majerič

Anžel

et al. 2020

Mater. Res. Express

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“…One of the key problems for a wider application of GNPs in medicine is the underdeveloped production technologies for GNP production, leading to large batch-to-batch variations in GNPs' properties. This problem could be overcome by using USP technology, enabling large-scale production of GNPs in a relatively short time [26,39]. Here, we used USP-generated GNPs about 20 nm in diameter with an SPR peak at 530 nm.…”

Section: Discussionmentioning

confidence: 99%

“…Sodium Citrate solution (0.1%) at pH 3.5 was used in the collection bottle for the generation of SC-GNPs. Alternatively, GNPs were collected in bottles containing 0.1% Poly-Ethylene Glycol (PEG)-5000 [26] or 1% PVP in water [31], for the generation of PEG-GNPs and PVP-GNPs, respectively. All types of GNPs were characterised as described previously [26,29,32].…”

Section: Synthesis and Characterisation Of Gold Nanoparticlesmentioning

confidence: 99%

“…Alternatively, GNPs were collected in bottles containing 0.1% Poly-Ethylene Glycol (PEG)-5000 [26] or 1% PVP in water [31], for the generation of PEG-GNPs and PVP-GNPs, respectively. All types of GNPs were characterised as described previously [26,29,32]. Briefly, TEM (CTEM; JEOL 2100) and SEM (FEI Quanta 200 3D) analyses were performed by placing a drop of colloidal suspension of c-GNPs onto a formvar film coated with a layer of carbon, or a lacey formvar film enforced by a heavy coating of carbon copper grid, and dried.…”

Section: Synthesis and Characterisation Of Gold Nanoparticlesmentioning

confidence: 99%

“…Previously, we showed that ultrasonic spray pyrolysis (USP) is a great tool for large scale production of GNPs, even from gold scrap [9]. Over the years, we upgraded the production technology of GNPs via USP in different ways [26][27][28][29]. However, a critical step for a successful biomedical application of GNPs is their stability in water solution.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Stabilisation Agents on the Immunomodulatory Properties of Gold Nanoparticles Obtained by Ultrasonic Spray Pyrolysis

et al. 2019

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Gold nanoparticles (GNPs) have been investigated extensively as drug carriers in tumour immunotherapy in combination with photothermal therapy. For this purpose, GNPs should be stabilised in biological fluids. The goal of this study was to examine how stabilisation agents influence cytotoxicity and immune response in vitro. Spherical GNPs, 20 nm in size, were prepared by ultrasonic spray pyrolysis (USP). Three types of stabilising agents were used: sodium citrate (SC), polyvinyl-pyrrolidone (PVP), and poly-ethylene glycol (PEG). Pristine, non-stabilised GNPs were used as a control. The culture models were mouse L929 cells, B16F10 melanoma cells and human peripheral blood mononuclear cells (PBMNCs), obtained from healthy donors. Control SC- and PEG-GNPs were non-cytotoxic at concentrations (range 1–100 µg/mL), in contrast to PVP-GNPs, which were cytotoxic at higher concentrations. Control GNPs inhibited the production of IFN-ϒ slightly, and augmented the production of IL-10 by PHA-stimulated PBMNC cultures. PEG-GNPs inhibited the production of pro-inflammatory cytokines (IL-1, IL-6, IL-8, TNF-α) and Th1-related cytokines (IFN-ϒ and IL-12p70), and increased the production of Th2 cytokines (IL-4 and IL-5). SC-PEG inhibited the production of IL-8 and IL-17A. In contrast, PVP-GNPs stimulated the production of pro-inflammatory cytokines, Th1 cytokines, and IL-17A, but also IL-10. When uptake of GNPs by monocytes/macrophages in PBMNC cultures was analysed, the ingestion of PEG- GNPs was significantly lower compared to SC- and PVP-GNPs. In conclusion, stabilisation agents modulate biocompatibility and immune response significantly, so their adequate choice for preparation of GNPs is an important factor when considering the use of GNPs for application in vivo.

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Successful Synthesis of Gold Nanoparticles through Ultrasonic Spray Pyrolysis from a Gold(III) Nitrate Precursor and Their Interaction with a High Electron Beam

et al. 2018

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Herein, we report for the first time the successful preparation of a gold(III) nitrate [Au(NO3)3] water‐based precursor for use in a bottom‐up ultrasonic spray pyrolysis (USP) process. Due to its limited solubility in water, the precursor was prepared under reflux conditions with nitric acid (HNO3) as the solvent and ammonium hydroxide (NH4OH) as a neutralizer. This precursor enabled the USP synthesis of gold nanoparticles (AuNPs) and the in situ formation of low concentrations of NO2 − and NO3 − ions, which were caught directly in deionized water in a collection system. These ions were proven to act as stabilizers for the AuNPs. Investigations showed that the AuNPs were monodispersed and spherically shaped with a size distribution over three groups: the first contained 5.3 % AuNPs with diameters (2 r) <15 nm, the second contained 82.5 % AuNPs with 2 r between 15 and 200 nm, and the third contained 12.2 % AuNPs with 2 r>200 nm. UV/Vis spectroscopy revealed the maximum absorbance band of the AuNPs at λ=528 nm. Additionally, scanning transmission electron microscopy (STEM) observations of the smallest AuNPs (2 r<5 nm) revealed atomically resolved coalescence phenomena induced by interaction with the electron beam. Four stages of the particle‐growth process were distinguished: 1) movement and rotation of the AuNPs; 2) necking mechanism; 3) orientated attachment at matching facets; 4) reshaping of the AuNPs by surface diffusion. This provided important insight into the formation/synthesis process of the AuNPs.

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Application of Gold(III) Acetate as a New Precursor for the Synthesis of Gold Nanoparticles in PEG Through Ultrasonic Spray Pyrolysis

Cited by 21 publications

References 64 publications

Low-cost synthesis of AuNPs through ultrasonic spray pyrolysis

Low-cost synthesis of AuNPs through ultrasonic spray pyrolysis

The Effect of Stabilisation Agents on the Immunomodulatory Properties of Gold Nanoparticles Obtained by Ultrasonic Spray Pyrolysis

Successful Synthesis of Gold Nanoparticles through Ultrasonic Spray Pyrolysis from a Gold(III) Nitrate Precursor and Their Interaction with a High Electron Beam

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