Application of graphene oxide in tumor targeting and tumor therapy

Zhang, Jia; Yang, Yibo; Li, Kun; Li, Jian

doi:10.1080/09205063.2023.2265171

Cited by 4 publications

(1 citation statement)

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“…In the context of tumor therapy, GO is often used as a nano-carrier due to its ability to load a large number of hydrophobic drugs containing benzene rings. Its nano-network structure and hydrophobicity play a crucial role in this process [16,17]. Additionally, GO's surface properties can be affected by pH changes [18].…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide Nanoparticles and Organoids: A Prospective Advanced Model for Pancreatic Cancer Research

Mai,

Inkielewicz-Stepniak

2024

IJMS

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Pancreatic cancer, notorious for its grim 10% five-year survival rate, poses significant clinical challenges, largely due to late-stage diagnosis and limited therapeutic options. This review delves into the generation of organoids, including those derived from resected tissues, biopsies, pluripotent stem cells, and adult stem cells, as well as the advancements in 3D printing. It explores the complexities of the tumor microenvironment, emphasizing culture media, the integration of non-neoplastic cells, and angiogenesis. Additionally, the review examines the multifaceted properties of graphene oxide (GO), such as its mechanical, thermal, electrical, chemical, and optical attributes, and their implications in cancer diagnostics and therapeutics. GO’s unique properties facilitate its interaction with tumors, allowing targeted drug delivery and enhanced imaging for early detection and treatment. The integration of GO with 3D cultured organoid systems, particularly in pancreatic cancer research, is critically analyzed, highlighting current limitations and future potential. This innovative approach has the promise to transform personalized medicine, improve drug screening efficiency, and aid biomarker discovery in this aggressive disease. Through this review, we offer a balanced perspective on the advancements and future prospects in pancreatic cancer research, harnessing the potential of organoids and GO.

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Section: Introductionmentioning

confidence: 99%