Application of green synthesised copper iodide particles on cotton fabric-protective face mask material against COVID-19 pandemic

Abstract

Microorganisms cause variety of diseases that constitutes a severe threat to mankind. Due to the upsurge of many infectious diseases, there is a high requirement and demand for the development of safety products finished with antimicrobial properties. The study involves the antimicrobial activity of natural cotton coated with copper iodide capped with Hibiscus rosa-sinensis L. flower extract (CuI-FE) which is rich in anthocyanin, cyanidine-3-sophoroside by ultrasonication method. The coated and uncoated cotton fabric was characterised through XRD, SEM, AFM, tensile strength and UV-Visible spectroscopic techniques. XRD confirmed the formation of CuI particles, SEM showed that CuI-FE was prismatic in shape. The average size of CuI-FE particles was found to be 552.45 nm. Anti-bacterial studies showed copper iodide particles to be a potent antimicrobial agent. AFM images confirmed the rupture of bacterial cell walls in the presence of prismatic CuI-FE. In-vitro cytotoxicity investigation of CuI-FE was performed against cancer and spleen cell lines to evaluate the cell viability. Cytotoxicity analysis revealed the IC 50 value of 233.93 μg/mL in the presence of CuI-FE. Molecular docking study was also carried out to understand the interaction of CuI-FE with COVID-19 main protease. This paper has given an insight on the usage of CuI-FE coated on the cotton fabric that has proved to have strong inhibition against the nano ranged bacterial, cancerous cell line and a strong interaction with the COVID-19 protease.Such eco-friendly material will provide a safe environment even after the disposable of medical waste from the infectious diseases like influenza and current pandemic like COVID-19.

Nanostructured coatings based on metallic nanoparticles as viral entry inhibitor to combat COVID-19

“…Such surfaces resist the entry the virus into human cell by passivation of receptors spikes. For instance, Archana et al [ 80 ] reported about coating of copper iodide on cotton fabrics by ultrasonication method. In this study, copper iodide was synthesized by the use of aqueous extract of Hibiscus flower as a source of reducing, stabilizing and capping agents.…”

Recent advances of nanotechnology in COVID 19: A critical review and future perspective

“… FE-CuI NPs engineered cotton mask provides better viral entry inhibition capacity. [154] Deng et al, mRNA incorporated lipid NPs (mRNA- HB 27 -LNPs Antiviral efficacy against corona virus In- vivo study speculated the improved circulating half-life with greater protection against virus after i.v administration of mRNA-HB 27 -LNPs into mice model. [155] Sanna et al, Remdesivir loaded targeted NPs (RDV-TNP-1 Antiviral activity against COVID 19 RDV-TNP-1 showed highest binding propensity to ACE2 receptor with enhanced antiviral efficacy and better biocompatibility.…”

Recent breakthroughs in nanostructured antiviral coating and filtration materials: a brief review

“…For instance, CuI-capped Hibiscus rosa-sinensis L. flower extract (CuI-FE) containing a pentanoic acid and 2-(aminooxy) nanocomposite (NC) coated on cotton fabric shows high tensile strength and elongation (TS 31.58 MPa and EAB 21%, respectively) with the ability to interact with COVID-19 protease (binding energy −80.34 kcal mol −1 ). 26 Aerosol droplets become entrapped and inactivated, and the efficiency of the face mask material was enhanced by assembling the mask barrier in three layers such that the outer two layers contained CuS NPs coated and impregnated onto 20D spandex, 70D nylon, and 75D polyester fibers that are organized in supercoiled and vertical orientations ( Fig. 2 ).…”