Application of green tea extracts epigallocatechin‐3‐gallate in dental materials: Recent progress and perspectives

Abstract

Because of excellent biocompatibility, antioxidant activity, and anti-caries ability, epigallocatechin-3-gallate (EGCG) has been widely studied in the treatment of oral diseases, such as periodontal disease, oral cancer, and dental caries. To reach the site of the lesion or achieve sustained release, play the role of anti-caries, anti-inflammatory, or to maintain or improve the physical properties of the modified material， EGCG need to be cross-linked or embedded with dental adhesives, barrier membranes, bone replacement materials, tissue regeneration materials, and antimicrobial anti-caries materials to better prevent or treat oral diseases. This article reviews the applications of EGCG in oral materials, involving various areas of the oral cavity, reveals their excellent potential, and sees shortcomings in these research to promote the better development of EGCG applications in oral materials such as oral repair materials, bone tissue engineering materials and antibacterial and anti-caries materials.

Green and white teas as health-promoting foods

“…70 In several studies, polyphenols from green tea extracts, particularly EGCG and ECG, were effective against Pseudomonas aeruginosa, Clostridium botulinum, Bacillus cereus, Escherichia coli, Salmonella and Staphylococcus aureus. 23,25,70,77 They damaged the cell membrane affecting the regulation of peptidoglycan biosynthesis and generating an alteration in the structure of the cell wall. 70 Lower concentrations of EGCG and ECG are necessary to exert effects on Gram-positive bacteria than on Gram-negative.…”

“…Effects on dermatological health and antiallergic effect Several studies have described the beneficial properties of green tea extracts on dermatological health. 25,77,83 Green tea is effective in treating acne due to its anti-inflammatory and antioxidant properties. 83 In a recent meta-analysis, the topical application of green tea extract significantly reduced the number of inflammatory lesions, while oral intake showed a slight effect thanks to its antiinflammatory and antimicrobial properties.…”

“…It was found that tea tannins can affect haemostasis, reducing bleeding time and promoting the wound healing process by significantly reducing bleeding time. 77 Polyphenols exert some protection against harmful effects of UV rays on collagen. 25 Topical application of green tea polyphenols can reduce skin flaking.…”

Efeito antitumoral do chá verde no carcinoma de células escamosas oral: Revisão integrativa

“…Os chás derivados da planta medicinal Camellia sinensis incluem o chá verde, preto e oolong, e seus hábitos de consumo variam culturalmente (Filippini et al, 2020). A Camellia sinensis contém polifenóis que são representantes do subgrupo catequinas e devido a sua biocompatibilidade e ação antioxidante, seu potencial de inibição da proliferação de células cancerosas vem sendo estudado a fim de validar seu uso como prevenção ou tratamento coadjuvante na terapia do câncer (Filippini et al, 2020;Liao et al, 2020).…”

“…Os principais polifenóis encontrados no chá verde são a epigalocatequina-3-galato (EGCG), epigalocatequina (EGC), epicatequina-3-galato (ECG) e epicatequina (EC). O consumo regular dos polifenóis tem sido associado a um risco reduzido de uma série de doenças crônicas, doenças cardiovasculares, neurodegenerativas e câncer (Chowdhury et al, 2016;Liao et al, 2020). Dentre os compostos do chá verde, destaca-se a epigalocatequina-3-galato (EGCG), caracterizada como um composto natural e devido a sua segurança e perfil de toxicologia, vem sendo considerada uma droga promissora para a prevenção e terapia do câncer (Maggioni et al, 2015).…”