Application of green technology on extraction of phenolic compounds in oilseeds (Canola)

Nandasiri, Ruchira; Eskin, N.A.M.; Eck, Peter; Thiyam‐Holländer, Usha

doi:10.1016/b978-0-12-818188-1.00008-6

Cited by 16 publications

(14 citation statements)

References 68 publications

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“…In the present study, the solvent for the extraction of U. barbata secondary metabolites was canola oil (CNO). Unlike chemical solvents, CNO has its own bioactive constituents [ 103 ] and could make a suitable extraction of lichen secondary metabolites. Canola oil consists of cold-pressed rapeseed ( Brassica napus ) oil with a low erucic acid content and glucosinolate one [ 104 ].…”

Section: Discussionmentioning

confidence: 99%

ROS-Induced DNA-Damage and Autophagy in Oral Squamous Cell Carcinoma by Usnea barbata Oil Extract—An In Vitro Study

Popovici

Musuc

Matei

et al. 2022

IJMS

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Oxidative stress is associated with aging, cancers, and numerous metabolic and chronic disorders, and phenolic compounds are well known for their health-promoting role due to their free-radical scavenging activity. These phytochemicals could also exhibit pro-oxidant effects. Due to its bioactive phenolic secondary metabolites, Usnea barbata (L.) Weber ex. F.H. Wigg (U. barbata) displays anticancer and antioxidant activities and has been used as a phytomedicine for thousands of years. The present work aims to analyze the properties of U. barbata extract in canola oil (UBO). The UBO cytotoxicity on oral squamous cell carcinoma (OSCC) CLS-354 cell line and blood cell cultures was explored through complex flow cytometry analyses regarding apoptosis, reactive oxygen species (ROS) levels, the enzymatic activity of caspase 3/7, cell cycle, nuclear shrinkage (NS), autophagy (A), and synthesis of deoxyribonucleic acid (DNA). All these studies were concomitantly performed on canola oil (CNO) to evidence the interaction of lichen metabolites with the constituents of this green solvent used for extraction. The obtained data evidenced that UBO inhibited CLS-354 oral cancer cell proliferation through ROS generation (316.67 × 104), determining higher levels of nuclear shrinkage (40.12%), cell cycle arrest in G0/G1 (92.51%; G0 is the differentiation phase, while during G1 phase occurs preparation for cell division), DNA fragmentation (2.97%), and autophagy (62.98%) than in blood cells. At a substantially higher ROS level in blood cells (5250.00 × 104), the processes that lead to cell death—NS (30.05%), cell cycle arrest in G0/G1 (86.30%), DNA fragmentation (0.72%), and autophagy (39.37%)—are considerably lower than in CLS-354 oral cancer cells. Our work reveals the ROS-mediated anticancer potential of UBO through DNA damage and autophagy. Moreover, the present study suggests that UBO pharmacological potential could result from the synergism between lichen secondary metabolites and canola oil phytoconstituents.

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Section: Discussionmentioning

confidence: 99%

ROS-Induced DNA-Damage and Autophagy in Oral Squamous Cell Carcinoma by Usnea barbata Oil Extract—An In Vitro Study

Popovici

Musuc

Matei

et al. 2022

IJMS

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“…However, there exists no single universal acceptable solvent for this kind of extraction. The conventional methods for the extraction of bioactive compounds from plants in general are Soxhlet extraction, maceration and hydro-distillation (water, direct steam or water-steam distillation) [131][132][133][134]. This extraction step is then followed by a desolventization step of the meal, and a separation and purification step of the extracted bioactive compound.…”

Section: Viewmentioning

confidence: 99%

Bio-Refinery of Oilseeds: Oil Extraction, Secondary Metabolites Separation towards Protein Meal Valorisation—A Review

et al. 2022

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Edible oil extraction is a large and well-developed sector based on solvent assisted extraction using volatile organic compounds such as hexane. The extraction of oil from oilseeds generates large volumes of oilseed by-products rich in proteins, fibres, minerals and secondary metabolites that can be valued. This work reviews the current status and the bio-macro-composition of oilseeds, namely soybean, rapeseed, sunflower and flaxseed, and the refining process, comprising the extraction of oil, the valorisation and separation of valuable secondary metabolites such as phenolic compounds, and the removal of anti-nutritional factors such as glucosinolates, while retaining the protein in the oilseed meal. It also provides an overview of alternative solvents and some of the unconventional processes used as a replacement to the conventional extraction of edible oil, as well as the solvents used for the extraction of secondary metabolites and anti-nutritional factors. These biologically active compounds, including oils, are primordial raw materials for several industries such as food, pharmaceutical or cosmetics.

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“…Besides, recently, a greater need and growing demand to valorize by‐products obtaining biocompounds of agricultural goods such as those derived from the fruit, grain, and seed industries have been detected (Fidelis et al., 2019; Mildner‐Szkudlarz et al., 2016; Mourtzinos & Goula, 2019; Ou et al., 2019; Zayed et al., 2021). Currently, there are studies about the exploitation of oilseed by‐products, like cakes or meals resulting from oil extraction, as good sources of valuable protein including protein isolates and hydrolysates (Du et al., 2022; Kotecka‐Majchrzak et al., 2020; Naik et al., 2022), phenolic compounds (Nandasiri et al., 2020; Ou et al., 2019; Zardo et al., 2019), and polysaccharides (Silva et al., 2022; Wang et al., 2022; Wu et al., 2019; Zheng et al., 2016). Besides, bioactive compound extraction from seeds considered by‐products from other food sectors such as fruit as well as the development of new products have been proposed (Bian et al., 2022; Fidelis et al., 2019; Mildner‐Szkudlarz et al., 2016; Mourtzinos & Goula, 2019; Ou et al., 2019; Sirichan et al., 2022; Wang et al., 2019; Zayed et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound‐assisted extraction of oilseeds—sustainability processes to obtain traditional and non‐traditional food ingredients: A review

Chalapud

Carrín

2023

Comp Rev Food Sci Food Safe

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Oilseeds are sources of not only major compounds such as oil and meal but also of bioactive compounds. Their conventional extraction is related to long extraction time, large non-renewable solvent consumption, high temperature, and therefore, high energy consumption. Ultrasound-assisted extraction (UAE) has emerged as a new and green technology, which can accelerate and/or improve the extraction process of these compounds. Moreover, the possibility of using renewable solvents in the UAE enhances its application and allows obtaining both extracted and remaining products more compatible with current human consumption requirements. This article examines the mechanisms, concepts, and factors that impact oilseeds' UAE with an emphasis on the extraction yield and quality of oil, meal, and bioactive compounds. Furthermore, the effects of combining UAE with other technologies are addressed. Gaps detected in the analyzed literature about oilseed treatment and quality and properties of products, in addition to perspectives about their uses as food ingredients, are also included.Moreover, it highlights the need for increasing research on process scalability, on environmental and economic impacts of the whole process, and on the phenomenological description about the effect of process variables on extraction performances, which will be a key tool for process design, optimization, and control. Understanding ultrasound processing techniques for the extraction of different compounds from oilseeds will serve as useful information for fats and oils and meal scientists in academia and industry to explore the possibility of employing this sustainable approach during the extraction treatment of various crops.

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Application of green technology on extraction of phenolic compounds in oilseeds (Canola)

Cited by 16 publications

References 68 publications

ROS-Induced DNA-Damage and Autophagy in Oral Squamous Cell Carcinoma by Usnea barbata Oil Extract—An In Vitro Study

ROS-Induced DNA-Damage and Autophagy in Oral Squamous Cell Carcinoma by Usnea barbata Oil Extract—An In Vitro Study

Bio-Refinery of Oilseeds: Oil Extraction, Secondary Metabolites Separation towards Protein Meal Valorisation—A Review

Ultrasound‐assisted extraction of oilseeds—sustainability processes to obtain traditional and non‐traditional food ingredients: A review

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