Application of HIFU technology in angiology

Николаевич, Петрищев Николай; Юрьевич, Семенов Дмитрий; Юрьевич, Цибин Андрей; Ефимович, Беркович Александр; Арнольдович, Бурсиан Андрей

doi:10.24884/0042-4625-2017-176-5-101-105

Cited by 4 publications

(3 citation statements)

References 36 publications

(40 reference statements)

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“…Focused ultrasound is a promising method of human internal tissues heating [1][2][3][4][5]. However, its application is possible only if complete information about the spatial and temporal variations of temperature inside the biological tissue is available.…”

Section: Objectivesmentioning

confidence: 99%

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On accuracy estimation of ultrasonic thermometry technique with heated wire method

et al. 2018

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Section: Objectivesmentioning

confidence: 99%

“…During the last two decades this method is being developed in a number of scientific centers [7][8][9]. Animal studies are carried out for approbation of the method [10][11][12][13]. The sensitivity of the method is evaluated on test objects with known temperature fields [14][15].…”

Section: Objectivesmentioning

confidence: 99%

On accuracy estimation of ultrasonic thermometry technique with heated wire method

et al. 2018

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“…At the same time, the most common and well-known technology is the ultrasound ablation of soft tissues [5][6][7][8][9][10][11] using HIFU through coagulation necrosis of malignant neoplasms and other soft tissue regions with pathological changes. Strong wave focusing and high radiation intensity in such traditional medical applications are necessary to achieve high temperature (about 80˚-90˚С) in the focal region resulting in thermal ablation of soft tissue.…”

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confidence: 99%

Spatial Resolution and Measurement Accuracy of the Ultrasound Diagnostic System at Acoustic Remote Palpation Using High Intensity Focusing Ultrasound

Barannik

Pupchenko

Marusenko

et al. 2019

EEJP

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In this work the spatial resolution and measurement accuracy of the ultrasound diagnostic system at acoustic remote palpation (ARP) using high-intensity focusing ultrasound (HIFU) are studied theoretically and experimentally. A physical model is proposed, which describes the specific features of ARP taking into account the remote nature of ultrasound Doppler probing of the soft tissues local movements, which are caused by the radiation pressure of HIFU pulse. Taking into account the accepted simplifying assumptions it is shown that the model conclusions are in a good agreement with the results of the experiments on measuring the value of displacements under the influence of HIFU. In particular, the nontrivial dependence of the value of displacements, measured by the Doppler method, on the probing depth and focusing degree of the incident and scattered wave beams, is proved. An experimental study was performed on the transverse resolution at ARP in the case of probing of the medium with Young's modulus irregularity, as well as on the influence of noise and interference on the measurement accuracy and resolution. It is concluded, that the transverse resolution at ARP is determined by the parameters of the local area of the movement, and can be significantly higher than the transverse intrinsic resolution of the ultrasound system at B-mode of diagnostics. The obtained results indicate that ARP is a promising method for monitoring the process of the soft tissues thermal ablation, when HIFU is used.

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Zonal pattern of blood flow distribution in the Pliss lymphosarcoma microcirculatory bed caused by single exposure of high-intensity focused ultrasound

Gryzunov¹,

Grishachevа²,

Chefu³

et al. 2022

Regional blood circulation and microcirculation

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Introduction. Cell damage is not the only important mechanism of high-intensity focused ultrasound (HIFU) for cancer therapy; concomitant microcirculation disorders having alterations patterns not studied enough also have high significance. The aim of the study was to analyze perfusion along the tumor perimeter depending on the HIFU exposure. Materials and methods. We used a stand for HIFU therapy (MTL LLC). Mode: 8.2 kW/cm2 intensity at 0.6 mm focal spot at 1.4 MHz, exposure time: 150, 200, 250 and 500 ms. The object of the study is the vascular bed of Pliss lymphosarcoma. Tumor tissue temperature was monitored by a T-8 thermograph (Russia), blood flow was measured by the BLF21 laser Doppler recorder (USA). Results. After HIFU exposure time from 150–250 ms, perfusion was noted to have decreased to 1.06 perfusion units (pf.u) in the central zone (p<0.01) compared to the control, but by the 30 min perfusion has increased to 1.22 pf.un. No signs of perfusion improvement were found in exposure time of 500 ms. In the peripheral zone, against the background of a decrease in blood flow to 3.6 pf. u. (p < 0.05) by 30 min of the experiment, hyperperfusion was restored to 5.86 pf. u. in all exposure time. In the central zone, a sharp decrease in microcirculation was observed, probably caused by damage of blood vessels; in the periphery of the tumor, perfusion changes had a phasic and reversible pattern. Conclusion. An increase of HIFU exposure correlates with an increase of temperature of Pliss lymphosarcoma tissue near the focus of exposure. Specific perfusion changes are recorded in the central and peripheral zones of the tumor when single exposed to HIFU with different time exposure; the severity of changes depends on ultrasound exposure-time and is characterized by a zonal pattern of blood flow distribution due to the formation of zones of irreversible and reversible damage to microcirculation.

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Application of HIFU technology in angiology

Cited by 4 publications

References 36 publications

On accuracy estimation of ultrasonic thermometry technique with heated wire method

On accuracy estimation of ultrasonic thermometry technique with heated wire method

Spatial Resolution and Measurement Accuracy of the Ultrasound Diagnostic System at Acoustic Remote Palpation Using High Intensity Focusing Ultrasound

Zonal pattern of blood flow distribution in the Pliss lymphosarcoma microcirculatory bed caused by single exposure of high-intensity focused ultrasound

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