Application of high-frequency magnetron sputtering to deposit thin calcium-phosphate biocompatible coatings on a titanium surface

Пичугин, В. Ф.; Eshenko, E. V.; Surmenev, Roman A.; Shesterikov, E. V.; Tverdokhlebov, Sergei I.; Ryabtseva, M. A.; Сохорева, В. В.; Хлусов, И. А.

doi:10.1134/s1027451007060109

Cited by 23 publications

(12 citation statements)

References 6 publications

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“…These bands are absent in the FTIR spectrum of Ap. The main band at 1022-1026 cm −1 corresponds to the asymmetric stretching mode of PO 4 3− groups (ν 3 PO4). The band at~962 cm −1 is ascribed to the symmetric stretching (ν 1 PO4), while less intense bands at~607 and 565 cm −1 are due to the bending mode of PO 4 3− groups (ν 4 PO4).…”

Section: Crystallographic and Spectroscopic Features Of The Nanocompomentioning

confidence: 99%

“…In clinical practice, for applications in dental and orthopedic surgery, they are usually employed as a bioactive coating on a metallic support, combining the biological properties of the apatite with the mechanical strength of the support, thus promoting a fast fixation within the surrounding bony tissue. To this end, different calcium phosphate (CaP) coating methods, employing biocompatible titanium and titanium alloy supports, were developed in the past [3][4][5][6][7]. When the apatite is used as a synthetic bone graft, however, because of its intrinsic brittleness and low fracture toughness, the use of a reinforcing material to form a composite scaffold with better mechanical properties is necessary.…”

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confidence: 99%

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Induced Nucleation of Biomimetic Nanoapatites on Exfoliated Graphene Biomolecule Flakes by Vapor Diffusion in Microdroplets

et al. 2019

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The nucleation of apatite nanoparticles on exfoliated graphene nanoflakes has been successfully carried out by the sitting drop vapor diffusion method, with the aim of producing cytocompatible hybrid nanocomposites of both components. The graphene flakes were prepared by the sonication-assisted, liquid-phase exfoliation technique, using the following biomolecules as dispersing surfactants: lysozyme, L-tryptophan, N-acetyl-D-glucosamine, and chitosan. Results from mineralogical, spectroscopic, and microscopic characterization (X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman, Variable pressure scanning electron microscopy (VPSEM), and transmission electron microscopy (TEM)) indicate that flakes were stacked in multilayers (> 5 layers) and most likely intercalated and functionalized with the biomolecules, while the apatite nanoparticles were found forming a coating on the graphene surfaces. It is worthwhile to mention that when using chitosan-exfoliated graphene, the composites were more homogeneous than when using the other biomolecule graphene flakes, suggesting that this polysaccharide, extremely rich in –OH groups, must be arranged on the graphene surface with the –OH groups pointing toward the solution, forming a more regular pattern for apatite nucleation. The findings by XRD and morphological analysis point to the role of “functionalized graphene” as a template, which induces heterogeneous nucleation and favors the growth of apatite on the flakes’ surfaces. The cytocompatibility tests of the resulting composites, evaluated by the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay in a dose–dependent manner on GTL-16 cells, a human gastric carcinoma cell line, and on m17.ASC cells, a murine mesenchymal stem cell line with osteogenic potential, reveal that in all cases, full cytocompatibility was found.

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Section: Crystallographic and Spectroscopic Features Of The Nanocompomentioning

confidence: 99%

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confidence: 99%

Induced Nucleation of Biomimetic Nanoapatites on Exfoliated Graphene Biomolecule Flakes by Vapor Diffusion in Microdroplets

et al. 2019

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“…Coatings were applied on titanium by means of anode-spark (microarc) oxidation method in 10 % phosphoric acid solution containing suspension of nano-sized (20 -40 nm) synthetic HAP particles with stoichiometric composition Са 10 (РО 4 ) 6 (ОН) 2 [6]. Smooth CP surfaces (Ra<1 µm) were formed by means of high-frequency magnetron sputtering of CP target electrode [7].…”

Section: A Titanium Specimens With Calcium Phosphate (Cp) Coating Prmentioning

confidence: 99%

Novel Concepts of “Niche-Relief” and “Niche-Voltage” for Stem Cells as a Base of Bone and Hematopoietic Tissues Biomimetic Engineering

et al. 2013

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-An affect of relief features and quantitative variables of artificial surfaces on structural-functional status of human lung prenatal stromal cells (HLPSC) and remodeling of Balb/c mice bone/bone marrow system have been studied. Implants with rough (Ra>2 μm) calcium phosphate micro-arc coatings have structural-functional sites (micro-regions) named "niches-relief" which are necessary for maturation and differentiation of HLPSC into secreting osteoblasts in shortterm culture. Maximal remodeling of mouse bone/bone marrow system in 45-day subcutaneous heterotopic test in vivo is also noted under optimal parameter (average index of cellular alkaline phosphatase area to artificial micro-region area is about 43 %) of osteogenic niche in vitro. Probable physical mechanism of osteogenic niche functioning has been determined. It correlates with increasing of electron work function (ϕ) supplied with a negative charge of calcium phosphate nanorelief in the sockets (artificial "niches"). "Niche-voltage" concept for bone tissue biomimetic engineering was proposed.

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“…Many studies indicate that Ti implants can be coated with calcium phosphate (e.g., hydroxyapatite) layers by various deposition methods such as electrodeposition, plasma spray, high-frequency magnetron sputtering, biomimetic precipitation, etc. [4][5][6][7][8]. In this way, the bioactivity, biocompatibility, and corrosion resistance of the Ti-based implants are improved.…”

Section: Introductionmentioning

confidence: 99%

Bismuth-Doped Nanohydroxyapatite Coatings on Titanium Implants for Improved Radiopacity and Antimicrobial Activity

Ciobanu

Harja

2019

Nanomaterials

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This study aims to present the possibility to obtain bismuth-doped nanohydroxyapatite coatings on the surface of the titanium implants by using a solution-derived process according to an established biomimetic methodology. The bioactivity of the titanium surface was increased by an alkali-thermal treatment. Then, under biomimetic conditions, the titanium surface was coated with a Bi-doped nanohydroxyapatite layer by using a modified supersaturated calcification solution (SCS) containing a bismuth salt. The apatite deposits were analyzed by scanning electron microscopy coupled with X-ray analysis (SEM-EDX), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and digital X-rays radiography method. The results indicate that the Bi-doped nanohydroxyapatite coatings on titanium surface were produced. These coatings exhibit a good radiopacity, thus enhancing their applications in dental and orthopedic fields. Additionally, the Bi-doped nanohydroxyapatite coatings show significant antimicrobial activity against Escherichia coli and Staphylococcus aureus bacteria.

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Application of high-frequency magnetron sputtering to deposit thin calcium-phosphate biocompatible coatings on a titanium surface

Cited by 23 publications

References 6 publications

Induced Nucleation of Biomimetic Nanoapatites on Exfoliated Graphene Biomolecule Flakes by Vapor Diffusion in Microdroplets

Induced Nucleation of Biomimetic Nanoapatites on Exfoliated Graphene Biomolecule Flakes by Vapor Diffusion in Microdroplets

Novel Concepts of “Niche-Relief” and “Niche-Voltage” for Stem Cells as a Base of Bone and Hematopoietic Tissues Biomimetic Engineering

Bismuth-Doped Nanohydroxyapatite Coatings on Titanium Implants for Improved Radiopacity and Antimicrobial Activity

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