The solvent diffusivity is considered as a key factor in the design of solvent assisted processes in the bitumen field. In this study, a novel Adaptive neuro-fuzzy interference system (
ANFIS
) is employed to evaluate the diffusivity of the light hydrocarbons in the bitumen system. The particle swarm optimization (
PSO
) and genetic algorithm (
GA
) are adopted to promote
ANFIS
efficiency. The proposed models are established by a prepared dataset from multiple papers in the literature. Temperature (T), pressure (P) and molecular weight of alkanes (Mw) were considered as the input variables and on the other hand, Statistical parameters and graphical methods were used to appraise
ANFIS
,
ANFIS-PSO
, and
ANFIS-GA
performance. The results demonstrated that the highest correlation coefficient is related to
ANFIS-PSO
with R
2
= 0.991 and 0.987 for train and test data, respectively. In the end, the results indicated that the
ANFIS-PSO
model has a higher level of desirability based on statistical parameters.