Application of Hydroalcoholic Solutions of Formaldehyde in Preparation of Acetylsalicylic Acid Gastro-Resistant Capsules

Preparation of a novel floating ring capsule-type dosage form for stomach specific delivery

“…Enteric gelatin bodies were prepared by crosslinking technique as described previously by Pina and Sousa (2002). Hard gelatin body was separated from the cap.…”

Hydrocolloids and Medicinal Chemistry Applications

“…Enteric Softgel capsules developed by Banner under the tradename EntericareÔ claim enteric properties by blending solutions of polymers used for enteric coating (polymethacrylate, Cellulose acetate Phthalate or Shellac) with gelatin solutions, however no twopiece hard capsule with enteric properties has been developed to date. Several attempts to form gelatin capsules by cross-linking with aldehydes have resulted in mixed success (Brown et al, 1998;Pina and Sousa, 2002;Marchais, 2003).…”

Polymer film formulations for the preparation of enteric pharmaceutical capsules

“…It is known that substances containing aldehyde groups can react with the gelatin, forming crosslinks [11,12] rendering the capsule insoluble and brittle on storage. Indeed, there have been attempts to utilise this property to create an enteric gelatin capsule with mixed success [13–16] . Therefore to produce a non‐animal‐based enteric two‐piece hard capsule is an attractive proposition.…”

“…Indeed, there have been attempts to utilise this property to create an enteric gelatin capsule with mixed success. [13][14][15][16] Therefore to produce a non-animal-based enteric two-piece hard capsule is an attractive proposition. Moreover, there has already been success in the production of a one-piece enteric softgel capsule [17] trademarked Entericare by Banner.…”