Application of ICP-MS for Multielement Analysis in Small Sample Amoun ts of Pathological Thyroid Tissue

Boulyga, Sergei F.; Becker, J. Sabine; Malenchenko, A.F.; Dietze, H.-J.

doi:10.1007/s006040050069

Cited by 31 publications

(27 citation statements)

References 2 publications

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“…NAA [30]), except, as above described ICP-MS measurement of zinc [29]. Values for cobalt in the healthy thyroids were higher by a factor of 3.1-4.7, and for manganese lower by factor of 1.9, respectively, compared with the literature values (Table 3).…”

Section: Comparison Of Metals' Contents In Healthy and Pathological Tmentioning

confidence: 81%

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Determination of cadmium, cobalt, copper, iron, manganese, and zinc in thyroid glands of patients with diagnosed nodular goitre using ion chromatography

Błażewicz

Dolliver

Sivsammye

et al. 2010

Journal of Chromatography B

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Section: Comparison Of Metals' Contents In Healthy and Pathological Tmentioning

confidence: 81%

“…However, one can find in literature a significantly higher value of zinc concentration in human thyroid samples obtained during operations on people living in regions of Belarus, i.e. 341 ± 16 g/g which was determined by the use of ICP-MS [29].…”

Section: Comparison Of Metals' Contents In Healthy and Pathological Tmentioning

confidence: 99%

Determination of cadmium, cobalt, copper, iron, manganese, and zinc in thyroid glands of patients with diagnosed nodular goitre using ion chromatography

Błażewicz

Dolliver

Sivsammye

et al. 2010

Journal of Chromatography B

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“…The reliable data on trace element mass fractions in normal geriatric thyroid is apparently extremely limited. There are many studies regarding trace element content in human thyroid, using chemical techniques and instrumental methods [25][26][27][28][29][30][31][32][33][34][35][36]. However, the majority of these data are based on measurements of processed tissue and in many studies tissue samples are ashed (are burned in a muffle furnace) before analysis.…”

mentioning

confidence: 99%

Age-Related-Changes-of-Trace-Element-Contents-in-Intact-Thyroid-of-Females-Investigated-by-Neutron-Activation-Analysis

Zaichick¹

2017

GGM

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IntroductionThe endocrine organs, including the thyroid gland, undergo important functional changes during aging and a prevalence of thyroid dysfunction is higher in the elderly as compared to the younger population [1,2]. Advancing age is known to influence the formation of adenomatous goiter and thyroid cancer [3]. The prevalence of thyroid nodules is increased in the elderly, reaching a frequency of nearly 50% by the age of 65 [4]. Both prevalence and aggressiveness of thyroid cancer increase with age [2]. Women are affected by thyroid nodule and cancer two to five times more often than men [2][3][4][5].Aging is a complex process involving biochemical and morphologic changes in single cells, in organs and in the whole organism. One of the most generally accepted explanations of how aging occurs at the molecular level is the oxidative stress hypothesis [6]. Reactive Oxygen Species (ROS) are widely considered to be a causal factor not only in aging but in a number of pathological conditions, including carcinogenesis. Aging, considered as an impairment of body functions over time, caused by the accumulation of molecular damage in DNA, proteins and lipids, is also characterized by an increase in intracellular oxidative stress due to the progressive decrease of the intracellular ROS scavenging [7]. Oxidative damage to cellular macromolecules which induce cancer can also arise through overproduction of ROS and faulty antioxidant and/or DNA repair mechanisms [8]. Overproduction of ROS is associated with inflammation, radiation and some other factors, including overload of some trace elements, in both blood and certain tissues, or deficiency of other trace elements with antioxidant properties [9][10][11][12][13][14][15]. Studies have shown that the imbalance in the composition of trace elements may cause different types of pathology. The importance of appropriate levels of many trace elements is indisputable, due to their beneficial roles when in specific concentration ranges, while on the other hand they can cause toxic effects with excessively high or low concentrations [12].In our previous studies [16][17][18][19][20][21][22][23][24] the high mass fraction of Iodine (I) and some other trace element were observed in intact human thyroid gland when compared with their levels in non-thyroid soft tissues of the human body. However, some questions about the age-dependence of trace element mass fraction in thyroid of adult, and particularly, elderly females still remain unanswered. One valuable way to elucidate the situation is to compare the mass fractions of trace elements in young adult (the control group) with those in older adult and geriatric thyroid. The findings of the excess or deficiency of trace element contents in thyroid and the perturbations of their relative proportions in glands of adult and elderly females, may give an indication of their role in a higher prevalence of thyroid dysfunction in the elderly. The reliable data on trace element mass fractions in normal geriatric thyroid is apparently extremel...

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“…Highly sensitive method of microspray quadrupole ICP MS provides analysis of biological samples weighting from 1 to 10 mg. The detection limits of different elements vary from tenth of ng/g (Sb, U) to units of µg/g (Fe, K, Mg, Na, As, Bi, Cd, Co, Hg, Mo, Pb, Rb, V) [101]. About 50 mg (dry weight equivalent) of the sample are used for NAA usually [102,103].…”

Section: The Methods Of the Determination Of The Elemental Concentratmentioning

confidence: 99%

Determination of the elemental composition of tissues of the cardiovascular system by atomic spectrometry, mass spectrometry and X-ray spectrometry methods

Зверева

Трунова

2012

J Anal Chem

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Application of ICP-MS for Multielement Analysis in Small Sample Amoun ts of Pathological Thyroid Tissue

Cited by 31 publications

References 2 publications

Determination of cadmium, cobalt, copper, iron, manganese, and zinc in thyroid glands of patients with diagnosed nodular goitre using ion chromatography

Determination of cadmium, cobalt, copper, iron, manganese, and zinc in thyroid glands of patients with diagnosed nodular goitre using ion chromatography

Age-Related-Changes-of-Trace-Element-Contents-in-Intact-Thyroid-of-Females-Investigated-by-Neutron-Activation-Analysis

Determination of the elemental composition of tissues of the cardiovascular system by atomic spectrometry, mass spectrometry and X-ray spectrometry methods

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