Application of IMRT in adjuvant treatment of soft tissue sarcomas of the thigh—Preliminary results

Abstract

Compared with 3D-CRT, the application of IMRT improves the dose distribution within the concave target volumes and reduces dose to the OAR structures without compromising target coverage.

Application of Volumetric Modulated Arc Therapy and Simultaneous Integrated Boost Techniques to Prepare “Safe Margin” in the Rabbit VX2 Limb Tumor Model

“…The VMAT showed a general improvement in sparing of organs at risk and healthy tissue, comparable target coverage, reduced beam-on time and lower number of monitor units (MU) compared with other IMRT approaches [ 12 ]. The SIB technique offers the possibility of reducing the number of fraction required, thus reducing the complexity and time of treatment delivery [ 13 ]. Scorsetti et al reported that the 3-week course of postoperative radiation using VMAT with SIB showed to be feasible and was associated with acceptable acute skin toxicity profilein breast cancer patients [ 12 ].In this study, we performed pre-operative radiotherapy in the rabbit VX2 limb tumor model using VMAT-SIB, and enhanced local injury by increasing the radiation dose at GTV boost area.…”

“…It can be delivered in less than 3 min, achieving excellent target coverage and normal tissue sparing with acceptable acute toxicity [ 10 – 12 ]. Using SIB technique, multiple target volumes receiving different prescribed doses can be integrated into a single treatment plan [ 13 ].Previous studies has shown that implementation of radiotherapy in the rabbit VX2 tumor model is feasible, and radiation can cause tumor necrosis[ 14 ].However, still is not reported, if the rabbit VX2 tumor model can implement VMAT-SIB technique.…”

Treatment of bone and soft tissue tumors of the limbs with conformal radiotherapy and intensity-modulated radiotherapy (IMRT)

“…All of them found greater conformity and dose homogeneity in treatment volumes and dose reduction for risk structures. [8][9][10] (C) Robinson et al compared the dosimetric plans of 11 patients with endometrial tumors between conventional radiotherapy and conformal radiotherapy. The volume of treatment with conformal radiotherapy was reduced in all patients.…”

“…It also promoted a decrease of 31% in the maximum and average doses released in the femur, in all patients. 10 12 (B), from the same institution, analyzed 319 patients with end-stage sarcomas treated with conservative limb surgery and adjuvant radiotherapy from 1996 to 2010. Of these, 154 were treated with conformal radiotherapy and 165 with IMRT technique.…”

Management of extremely hard‐to‐heal extremity wounds with severe life‐threatening complications

“…Today, amputation is ultimately required in approximately 10% of patients who suffer from sarcoma of the limbs with a tumour infiltrating crucial anatomical structures . While recent advances in radiotherapy enable more precise exposure of high doses of radiation to the tumour , damage to the surrounding tumour‐free tissue is still not completely inevitable and results in a wound complication rate of 40% . In this context, dose as well as the timing of radiotherapy appears to play an important role.…”