The complexity, increasing flow number and volumes, and challenges of last-mile logistics (LML) motivate or compel companies, authorities, and the entire community to think about ways to increase efficiency, reliability, and profits, reduce costs, reduce negative environmental impacts, etc. These objectives can be met by applying Industry 4.0 (I4.0) technologies, but the key question is which one. To solve this task, this paper used an innovative method that combines the fuzzy analytic network process (fuzzy ANP) and the fuzzy axial-distance-based aggregated measurement (fuzzy ADAM) method. The first was used for determining criteria weights and the second for selecting the best variant. The best solution is e/m-marketplaces, followed by cloud-computing-supported management and control systems and blockchain. These results indicate that widely adopted and implemented technologies are suitable for last-mile logistics. Newer technologies already producing significant results have serious potential for further development in this area. The main novelties and contributions of this paper are the definition of a new methodology based on multi-criteria decision-making (MCDM) methods, as well as its application for ranking I4.0 technologies for LML.