Application of infrared and nuclear magnetic resonance spectra in studying the bacterial efficacy of some oxazepane derivatives derived from hydrazones

Abstract

This research included the utilisation of infrared and nuclear magnetic resonance spectra in studying and preparing new derivatives of the oxazepan ring by a series of reactions, where the triazole ring was prepared from the reaction of the carboxylic acid with carbothiohydrazide, and from the resulting reaction (triazole) with aqueous hydrazine. The latter was reacted with benzaldehyde compensators to prepare hydrazones, which is the basic intermediate for the preparation of the oxazepan ring. The hydrazones were reacted with succinic anhydride, and the validity of the structures was proven using infrared and nuclear magnetic resonance spectra of proton and carbon. Its biological activity has also been tested for two species of Gram-positive bacteria, Staphylococcus epidermidis and Gram-negative Klebsiella pneumoniae.