Application of Infrared Spectroscopy to the Study of Renal Stones

Bellanato, J.; Delatte, L. Cifuentes; Hidalgo, Antonio Vásquez; Santos, Marcos José Leite

doi:10.1159/000394946

Cited by 13 publications

(11 citation statements)

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“…In this way, we could collect 857 stones < 5 mm in size, accounting for approximately one third of the total stones analyzed in the present study. Fortunately, the infrared analysis used in the present study is a simple and widely available method, which requires only a very small quan tity of sample, approximately 1 mg [12,13], making pos sible the analysis of even small stones that are approxi mately 1 mm in size.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Passage of Upper Urinary Tract Calculi in Relation to Composition

Ohkawa¹,

Tokunaga²,

Nakashima³

et al. 1993

Urol Int

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The composition of 2,755 calculi obtained from the upper urinary tract (1,409 by spontaneous passage and 1,346 by urological procedures) was analyzed using an infrared spectrophotometer, and the spontaneous passage rate was investigated in relation to the composition as well as other variables, such as stone size, and patient age and sex. Mixed stones of calcium oxalate and calcium phosphate were most frequently found, followed by those of calcium oxalate. The mean size (the maximum diameter) was largest in struvite stones and smallest in calcium oxalate ones. The sizes of stones from women were significantly larger than those from men (p < 0.01). As expected, the stone passage rates were inversely related to increasing stone size. The size of 55.6% of the stones passed was ≤ 5 mm, and that of 96.6% of the stones ≤ 10 mm.

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Section: Discussionmentioning

confidence: 99%

Spontaneous Passage of Upper Urinary Tract Calculi in Relation to Composition

Ohkawa¹,

Tokunaga²,

Nakashima³

et al. 1993

Urol Int

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“…This reliable method is expensive but develops slowly (1,3,6), it allows to differentiate the different types of Ca and Mg phosphates (carbonated or not), both forms of Ca oxalates and uric acids and to identify cystine and medi cinal crystals as well as 2.8 dihydroxyadenine calculi often mistaken for uric acids.…”

mentioning

confidence: 99%

Analysis of Urinary Calculi in Adults

Rj¹,

Daudon²,

Mf³

et al. 1980

Eur Urol

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“…Phosphate content was determined from the ratio of the absorbance of the 1035 cm 1 band (P-O stretch) to the 1310 cm I band (C-O stretch of COM), using known mixtures of hydroxyapatite and COM as standards. The presence of calcium oxalate dihydrate (COD) in some samples was indicated by a broadening and loss of resolution in the 3500-3000 cm i region and by a decreased absorbance ratio of the 780 to the 520 cm 1 bands [12]. In some cases COD could be confirmed by the presence of two water loss transitions by differential thermal analysis (Perkin-Elmer Model DSC-2) using 2 3 mg samples sealed in aluminum pans.…”

Section: Methodsmentioning

confidence: 99%

“…It seems reasonable that the analysis of renal calculi should entail, ideally, a layer-by-layer approach, in the manner of an archeological excavation, since these layers may contain clues of their origin and growth not other-wise accessible. Infrared spectroscopic analyses have indeed been carried out on successive layers of renal calculi [12], but thus far no similar investigation of matrix, with the goal of deducing information about its role in stone formation and growth, has been attempted. This paper describes our analysis of individual renal stones for matrix content as a function of radius by methods not involving demineralization or other separation steps, and our interpretation of the findings.…”

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confidence: 99%

Distribution of organic matrix in calcium oxalate renal calculi

et al. 1981

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The quantity of protein and carbohydrate comprising the matrix of calcium oxalate monohydrate (COM) renal stones was found to decrease with distance from the surface of the stone. The average organic concentration of stones 3 to 30 mm in diameter ranged from 5.7% at the surface to 2.7% at the core. This concentration gradient suggests matrix involvement in a "growth front" on stone surfaces with migration of organic material from the "older" interior. The matrix distribution was not readily correlated with density variations or with the presence of hydroxyapatite or calcium oxalate dihydrate. Surface matrix concentrations were greater than amounts predicted by physical adsorption. Electron microscopy confirmed the presence of the organic-rich surface layer and also suggested that increase in stone size occurs predominantly by crystal growth with microcrystal aggregates as growth centers.

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Application of Infrared Spectroscopy to the Study of Renal Stones

Cited by 13 publications

References 0 publications

Spontaneous Passage of Upper Urinary Tract Calculi in Relation to Composition

Spontaneous Passage of Upper Urinary Tract Calculi in Relation to Composition

Analysis of Urinary Calculi in Adults

Distribution of organic matrix in calcium oxalate renal calculi

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