Objective. To summarize the commonalities and particularities of comfort care interventions for neurology and general surgery patients. Methods. The development of comfort care and its practical application in neurology and general surgery were discussed and summarized by searching the current literature on comfort care interventions for neurology and general surgery patients, including case reports, clinical studies, and systematic reviews. Results. Comfort nursing intervention is a kind of nursing intervention with integrity and creativity. In addition to its uniqueness, the comfort nursing model also has strong effectiveness. Clinical holistic nursing has been significantly improved through the application of comfort nursing intervention theory, and its nursing mode has enhanced the connotation of clinical nursing. Conclusion. Comfort nursing intervention for neurology and general surgery patients can help patients recover and deserves further promotion.