Application of Interventional Bronchoscopic Therapy in Eight Pediatric Patients with Malignant Airway Tumors

Wang, Hongwu; Zhang, Nan; Tao, Meimei; Li, Dongmei; Zhou, Yunzhi; Zou, Hang; Liang, Sujuan; Li, Jing

doi:10.1177/030089161209800507

Cited by 15 publications

(14 citation statements)

References 16 publications

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“…12 This holds true for all primary tracheal tumors, as well. Although there are some reports on IMTs being managed with therapeutic bronchoscopy alone, 2,14,26,41,53,54 we found at least 5 instances in which bronchoscopy had to be followed up with surgery for either complete removal or recurrence (Tables 1, 2). 31,36,44,47 Thus, therapeutic bronchoscopy has a limited role in management of these tumors.…”

Section: Discussionmentioning

confidence: 80%

Inflammatory Myofibroblastic Tumor of the Trachea in the Pediatric Age Group

Jindal¹,

Bal²,

Agarwal³

2015

Journal of Bronchology &Amp; Interventional Pulmonology

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Inflammatory myofibroblastic tumors are uncommon tumors, which present as solitary masses in the pulmonary parenchyma. Tracheal involvement by these tumors is extremely rare and can be misdiagnosed as asthma. The closest histologic differential diagnoses are IgG4-related sclerosing pseudotumors, which are differentiated by IgG4 positivity. Fifty percent of inflammatory myofibroblastic tumors are positive for anaplastic lymphoma kinase gene rearrangements. The treatment modality of choice is surgical resection with therapeutic bronchoscopy reserved for patients presenting with acute airway obstruction or in those unwilling for surgery. New and upcoming treatments include anaplastic lymphoma kinase inhibitors like crizotinib.

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Section: Discussionmentioning

confidence: 80%

Inflammatory Myofibroblastic Tumor of the Trachea in the Pediatric Age Group

Jindal¹,

Bal²,

Agarwal³

2015

Journal of Bronchology &Amp; Interventional Pulmonology

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“…5 patients had to undergo repeat bronchoscopic procedures, following which the tumor was completely removed. [12,26,29,30] Surgery was done after primary bronchoscopic treatment in 12 patients. Indications for surgery were elective (3) [10,14,29] , incomplete bronchoscopic resection (2) [15,21] extraluminal component (1) [25] and recurrence (6) [18,23,27,28,32] .…”

Section: Discussionmentioning

confidence: 99%

Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis

Iyer¹,

Radonic²,

Heukamp

et al. 2020

ERJ Open Res

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Inflammatory myofibroblastic tumors (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the main stay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minimally invasive and lung function preserving modality in management of airway obstruction due to tumors. We present a series of 3 adult patients with IMT treated endo-bronchially with a short discussion on its potential role. We also discuss how molecular analysis of IMTs for mutations in genes such as ALK and ROS1 might provide insights into clinical behavior and potential targetable therapy in advanced, unresectable and metastatic cases.

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“…IF tumours were first described by Brunn in 1939 5–12. The lung parenchyma is the most commonly affected site,5–12 with only a few published reports relating to tracheal involvement 13. A report of 15 cases of IF tumours, of which four cases with tracheal involvement, described 52.3% of cases involving lung parenchyma and 46.7% the airways 14.…”

Section: Discussionmentioning

confidence: 99%

Intratracheal inflammatory myofibroblastic tumour mimicking severe acute asthma

et al. 2013

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SUMMARYA 3-year-old boy presented with severe airway obstruction which was diagnosed as asthma. He improved but had repeated episodes of severe airway obstruction. On clinical examination, he had a tracheal cough and monophonic wheezing. Imaging revealed a large lesion in the distal part of the trachea which was confirmed by bronchoscopy. The lesion was surgically removed. Histology revealed features characteristic of an inflammatory myofibroblastic tumour. Following the resection there is no recurrence of the lesion. BACKGROUND

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Application of Interventional Bronchoscopic Therapy in Eight Pediatric Patients with Malignant Airway Tumors

Abstract: There are no specific manifestations in children with malignant airway tumors. Interventional bronchoscopic therapy seems to be safe and effective for those tumors under general anesthesia.

Cited by 15 publications

References 16 publications

Inflammatory Myofibroblastic Tumor of the Trachea in the Pediatric Age Group

Inflammatory Myofibroblastic Tumor of the Trachea in the Pediatric Age Group

Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis

Intratracheal inflammatory myofibroblastic tumour mimicking severe acute asthma

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