Application of inulin/Eudragit RS in 5-ASA pellet coating with tuned, sustained-release feature in an animal model of ulcerative colitis

Sardou, Hossein Shahdadi; Akhgari, Abbas; Mohammadpour, Amir Hooshang; Kamali, Hossein; Jafarian, Amir Hossein; Garekani, Hadi Afrasiabi; Sadeghi, Fatemeh

doi:10.1016/j.ijpharm.2021.120347

Cited by 18 publications

(2 citation statements)

References 37 publications

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“…A randomized controlled trial supported the notion that oligofructose-enriched inulin can improve gastrointestinal symptoms in patients with active UC without significant side effects ( 143 ). Therefore, inulin is also being used increasingly for IBD treatment ( 144 , 145 ).…”

Section: Role Of Inulin In Diseasementioning

confidence: 99%

Immunomodulatory effects of inulin and its intestinal metabolites

Sheng

Zhang

2023

Front. Immunol.

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“Dietary fiber” (DF) refers to a type of carbohydrate that cannot be digested fully. DF is not an essential nutrient, but it plays an important part in enhancing digestive capacity and maintaining intestinal health. Therefore, DF supplementation in the daily diet is highly recommended. Inulin is a soluble DF, and commonly added to foods. Recently, several studies have found that dietary supplementation of inulin can improve metabolic function and regulate intestinal immunity. Inulin is fermented in the colon by the gut microbiota and a series of metabolites is generated. Among these metabolites, short-chain fatty acids provide energy to intestinal epithelial cells and participate in regulating the differentiation of immune cells. Inulin and its intestinal metabolites contribute to host immunity. This review summarizes the effect of inulin and its metabolites on intestinal immunity, and the underlying mechanisms of inulin in preventing diseases such as type 2 diabetes mellitus, inflammatory bowel disease, chronic kidney disease, and certain cancer types.

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Section: Role Of Inulin In Diseasementioning

confidence: 99%

Immunomodulatory effects of inulin and its intestinal metabolites

Sheng

Zhang

2023

Front. Immunol.

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“…In another study, inulin was shown to modulate the gut microbiota of patients by increasing the number of bifidobacteria by 2–3 times [ 114 ]. Inulin is also increasingly being used to produce drugs with applications in IBD [ 115 , 116 ].…”

Section: Link Between Dietary Fiber and Ibdmentioning

confidence: 99%

Components of the Fiber Diet in the Prevention and Treatment of IBD—An Update

2022

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Inflammatory bowel disease (IBD) is a group of diseases with a chronic course, characterized by periods of exacerbation and remission. One of the elements that could potentially predispose to IBD is, among others, a low-fiber diet. Dietary fiber has many functions in the human body. One of the most important is its influence on the composition of the intestinal microflora. Intestinal dysbiosis, as well as chronic inflammation that occurs, are hallmarks of IBD. Individual components of dietary fiber, such as β-glucan, pectin, starch, inulin, fructooligosaccharides, or hemicellulose, can significantly affect preventive effects in IBD by modulating the composition of the intestinal microbiota or sealing the intestinal barrier, among other things. The main objective of the review is to provide information on the effects of individual fiber components of the diet on the risk of IBD, including, among other things, altering the composition of the intestinal microbiota.

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A Biomarker‐Responsive Nanosystem with Colon‐Targeted Delivery for Ulcerative Colitis's Detection and Treatment with Optoacoustic/NIR‐II Fluorescence Imaging

Zeng

Ouyang

Sun

et al. 2022

Adv Healthcare Materials

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Ulcerative colitis (UC) is a prevalent idiopathic inflammatory disease which causes such complications as intestinal perforation, obstruction, and bleeding, and thus deleteriously impacting people's normal work and quality of life. Hence, accurate diagnosis of UC is crucial in terms of planning optimal treatment plan. Herein, a pH/reactive oxygen species (ROS) dual-responsive nanosystem (BM@EP) is developed for UC's detection and therapy. BM@EP is composed of a chromophore-drug dyad and the enteric coating. The chromophore-drug dyad (BOD-XT-DHM) is synthesized by linking the chromophore (BOD-XT-BOH) and a flavonoid drug (dihydromyricetin DHM) through boronate ester bond. The enteric coating includes Eudragit S100 and poly(lactic-co-glycolic acid) (PLGA), the former is commonly employed as a pH-dependent polymer coating excipient so as to attain colon-targeted delivery, and the latter has been widely used as an excipient for the controlled-extended release. After oral administration, BM@EP delivers the dyad (BOD-XT-DHM) into the colon and releases the dyad molecules by being triggered by the alkaline pH in t colon, thereafter upon being stimulated by overexpressed H 2 O 2 in the inflamed colon, the boronate bond in the dyad is broken down and correspondingly the drug DHM is released for UC therapy, simultaneously the chromophore is released for near-infrared second window (NIR-II) fluorescence and optoacoustic imaging for UC diagnosis and recovery evaluation.

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Application of inulin/Eudragit RS in 5-ASA pellet coating with tuned, sustained-release feature in an animal model of ulcerative colitis

Cited by 18 publications

References 37 publications

Immunomodulatory effects of inulin and its intestinal metabolites

Immunomodulatory effects of inulin and its intestinal metabolites

Components of the Fiber Diet in the Prevention and Treatment of IBD—An Update

A Biomarker‐Responsive Nanosystem with Colon‐Targeted Delivery for Ulcerative Colitis's Detection and Treatment with Optoacoustic/NIR‐II Fluorescence Imaging

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