Application of ion mobility spectrometry for the determination of tramadol in biological samples

Sheibani, Ali; Haghpazir, Najmeh

doi:10.1016/j.jfda.2014.02.001

Cited by 19 publications

(3 citation statements)

References 21 publications

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“…Basically, IM-MS enhances signal in tandem mass spectrometry (MS-MS). This additional component in the experimental setup for proteoform identification also enhances the detection of isomers and PTMs in the investigated sample [38][39][40][41].…”

Section: Enhancement Of Ms/ms In Top/middle-down Methodsmentioning

confidence: 99%

Mass Spectrometry-Based Proteomics: Analyses Related to Drug-Resistance and Disease Biomarkers

Agostini,

Traldi,

Hamdan

2023

Medicina

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Mass spectrometry-based proteomics is a key player in research efforts to characterize aberrant epigenetic alterations, including histone post-translational modifications and DNA methylation. Data generated by this approach complements and enrich datasets generated by genomic, epigenetic and transcriptomics approaches. These combined datasets can provide much-needed information on various mechanisms responsible for drug resistance, the discovery and validation of potential biomarkers for different diseases, the identification of signaling pathways, and genes and enzymes to be targeted by future therapies. The increasing use of high-resolution, high-accuracy mass spectrometers combined with more refined protein labeling and enrichment procedures enhanced the role of this approach in the investigation of these epigenetic modifications. In this review, we discuss recent MS-based studies, which are contributing to current research efforts to understand certain mechanisms behind drug resistance to therapy. We also discuss how these MS-based analyses are contributing to biomarkers discovery and validation.

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Section: Enhancement Of Ms/ms In Top/middle-down Methodsmentioning

confidence: 99%

Mass Spectrometry-Based Proteomics: Analyses Related to Drug-Resistance and Disease Biomarkers

Agostini,

Traldi,

Hamdan

2023

Medicina

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“…Literature review: Several methods were reported for determination of TMD alone in dosage forms and different biological fluids. HPLC [40,41], GC [42], Spectrometry [43,44], and even by electrochemical methods [45,46] were reported. Simultaneous determination of TMD with other analgesics was reported using LC [47][48][49].…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Erectile Dysfunction and Premature Ejaculation Drugs: Mode of Action and Analytical Methods Literature Review

Ae¹,

Elhenawee²,

Saleh³

et al. 2021

J Drug Res Dev

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“…In addition, HS-IMS presents a greater portability, since it works at atmospheric pressure. This technique has been successfully used for the discrimination of samples in many fields including the detection of adulterated food [ 27 , 28 ], explosives [ 29 , 30 ], drugs or pharmaceuticals substances [ 31 , 32 , 33 ] as well as for the characterization of ILs in fire debris [ 26 ]. However, how biological degradation may affect the correct identification of ILs when this technique is used is still to be studied.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Biodegraded Ignitable Liquids by Headspace–Ion Mobility Spectrometry

Calle

Ferreiro-González

Aliaño-González

et al. 2020

Sensors

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The detection of ignitable liquids (ILs) can be crucial when it comes to determining arson cases. Such identification of ILs is a challenging task that may be affected by a number of factors. Microbial degradation is considered one of three major processes that can alter the composition of IL residues. Since biodegradation is a time related phenomenon, it should be studied at different stages of development. This article presents a method based on ion mobility spectroscopy (IMS) which has been used as an electronic nose. In particular, ion mobility sum spectrum (IMSS) in combination with chemometric techniques (hierarchical cluster analysis (HCA) and linear discriminant analysis (LDA)) has been applied for the characterization of different biodegraded ILs. This method intends to use IMSS to identify a range of ILs regardless of their degree of biodegradation. Three ILs (diesel, gasoline and kerosene) from three different commercial brands were evaluated after remaining in a soil substrate for several lengths of time (0, 2, 5, 13 and 38 days). The HCA results showed the samples’ trend to fall into categories characterized by ILs type and biodegradation time. The LDAs allowed a 99% successful classification of the samples according to the IL type. This is the first time that an HS-IMS technique has been used to detect ILs that have undergone biodegradation processes. The results show that IMS may be a promising alternative to the current standard method based on gas-chromatography for the analysis of biodegraded ILs. Furthermore, no pretreatment of the samples nor the use of a solvent is required.

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Application of ion mobility spectrometry for the determination of tramadol in biological samples

Cited by 19 publications

References 21 publications

Mass Spectrometry-Based Proteomics: Analyses Related to Drug-Resistance and Disease Biomarkers

Mass Spectrometry-Based Proteomics: Analyses Related to Drug-Resistance and Disease Biomarkers

Erectile Dysfunction and Premature Ejaculation Drugs: Mode of Action and Analytical Methods Literature Review

Characterization of Biodegraded Ignitable Liquids by Headspace–Ion Mobility Spectrometry

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