Application of ion-pair extraction to partition chromatographic separation of pharmaceutical amines

Doyle, Thomas D.; Levine, Joseph

doi:10.1021/ac60255a001

Cited by 22 publications

(13 citation statements)

References 5 publications

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“…12-MPA obtained (7) but also the rate of its formation. Thus, sample acidity must be carefully controlled, and the reaction progress monitored to ensure that equilibrium has been reached.…”

Section: Discussionmentioning

confidence: 86%

“…The reagents were introduced to the rapid mixing chamber by means of a motor-driven three-way stopcock modified from the design of an automatic injection pipet (7). By pressing a pushbutton, the solutions were transferred from the reagent reservoirs to the 2-ml delivery syringes, which delivered 0.3 ml of each solution through the rapid mixing chamber.…”

Section: Methodsmentioning

confidence: 99%

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Investigations of formation of 12-molybdophosphoric acid utilizing rapid reaction-rate measurements

Javier¹,

Crouch²,

Malmstadt³

1968

Anal. Chem.

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Kinetics of the formation of 12-molybdophosphoric acid (12-MPA) has been investigated using rapid stoppedflow spectrophotometric reaction-rate techniques. A mechanism is proposed from the kinetic data which involves an initial reaction between phosphate ions and Mo(VI) followed by polymerization to form 12-molybdophosphoric acid. The rate law has been derived and is in agreement with the experimentally observed rates, and rate constants have been evaluated for the

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“…12-MPA obtained (7) but also the rate of its formation. Thus, sample acidity must be carefully controlled, and the reaction progress monitored to ensure that equilibrium has been reached.…”

Section: Discussionmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Investigations of formation of 12-molybdophosphoric acid utilizing rapid reaction-rate measurements

Javier¹,

Crouch²,

Malmstadt³

1968

Anal. Chem.

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“…The use of these ion-paired adsorption systems gave improved, more reproducible separations (16). Celite columns acidified with tosic acid, 0.1 or 1.0 M HC1,lO.O M H2S04, or 1.0 M H3P04 were used in ion-pair extraction followed by partition chromatography to separate pyrilamine and codeine (17). Other inorganic ions such as C1-, Br-, I-, Nos-, C104-, SCN-, and Sod2were also used (18).…”

Section: Background-production Of Antihistamines In Thementioning

confidence: 99%

Physical and Biological Properties of Pyrilamine

Haley

1983

Journal of Pharmaceutical Sciences

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“…Levine (3) showed that many alkoids, such as heroin, can be extracted as ion pairs by chloroform and other chlorinated hydrocarbons. The principles underlying the phenomenon are discussed by Doyle and Levine (4) and by Higuchi e[ al., (5) and are used as a basis for the separation of a wide range of pharmaceutical amines under various conditions.…”

Section: Resultsmentioning

confidence: 99%

Separation of isotopic methanes by gas chromatography

Bruner¹,

Cartoni²,

Possanzini³

1969

Anal. Chem.

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under these conditions a chemical reaction takes place between H?O?, H+, and NO?-(the radiation yield of NOz-was higher than that of H?Od and all the hydrogen peroxide was consumed. In the absence of NOn-the peak height of HzOn peaks was always proportional to the H202 concentration, obtained when NH4HS04 was used as the eluent.The elution curves of reference solutions of NaNOn, H202, and CH3NOr in N a N 0 3 obtained with 0.1M ("&SO4 are shown in Figure 2. Corresponding curves with 0.1M NH4HS04 are shown in Figure 3.The data obtained indicate that NOn-ions are sorbed only after neutralization to undissociated "02 molecules. The radiolytic products-Hz02, NO*-(in the form of "02) and CH3NOz-are sorbed on strongly acid Dowex 50 W-X8 (cationite), and their desorption proceeds in the order of increasing molecular weights as in the case of homologous series of nitroparaffins.The results indicate that chromatopolarography is applicable for the determination of radiolytic products.

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Application of ion-pair extraction to partition chromatographic separation of pharmaceutical amines

Cited by 22 publications

References 5 publications

Investigations of formation of 12-molybdophosphoric acid utilizing rapid reaction-rate measurements

Investigations of formation of 12-molybdophosphoric acid utilizing rapid reaction-rate measurements

Physical and Biological Properties of Pyrilamine

Separation of isotopic methanes by gas chromatography

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