Application of Irreversible Electroporation Ablation as Adjunctive Treatment for Margin Enhancement: Safety and Efficacy

Simmerman, Erika; Chung, Jane; Lawson, Andrew; Kruse, Edward

doi:10.1016/j.jss.2019.06.010

Cited by 13 publications

(16 citation statements)

References 32 publications

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“…In fact, irreversible electroporation (IRE), which induces a high proportion of cell death in the pulsed area, is currently used in the clinic as a tumor ablation technique for some accessible tumors. 54 We have shown previously that the antitumor effects of IRE can be potentiated by combining it with adjuvants able to promote type I IFN responses, such as poly(IC:LC) (polyinosinic-polycytidylic acid and poly-L-lysine, a dsRNA analog mimicking viral RNA) or STING agonists. 11 , 12 Based on these results, we reasoned that combination of electroporation with an saRNA expressing a potent immunostimulatory cytokine, such as IL-12, could further improve the antitumor effects of this technique.…”

Section: Discussionmentioning

confidence: 99%

Intratumoral electroporation of a self-amplifying RNA expressing IL-12 induces antitumor effects in mouse models of cancer

Silva-Pilipich

Lasarte-Cía

Lozano

et al. 2022

Molecular Therapy - Nucleic Acids

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Section: Discussionmentioning

confidence: 99%

Intratumoral electroporation of a self-amplifying RNA expressing IL-12 induces antitumor effects in mouse models of cancer

Silva-Pilipich

Lasarte-Cía

Lozano

et al. 2022

Molecular Therapy - Nucleic Acids

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“…Open surgery is preferred in the majority of published studies; it also enables the detection of peritoneal metastases. An other option is to perform the procedure during open surgery as adjuvant therapy to primary resection [49,50]. There is a growing trend in using percutaneous access, as it is less invasive and better tolerable by patients [51].…”

Section: Discussionmentioning

confidence: 99%

Benefitial role of electrochemotherapy in locally advanced pancreatic cancer – radiological perspective

Kozak¹,

Hać²,

Pieńkowska³

et al. 2022

Pol J Radiol

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Irreversible electroporation (IRE) of locally advanced pancreatic cancer is an increasingly used method for unresect able pancreatic cancer that can be used in cytoreduction followed by surgical treatment and shows promising results in palliative care.IRE is an ablative technique where electric pulses cause damage to the cell membrane leading to apoptosis without the destruction of stroma. The application of IRE increases the concentration of hydrophobic regimens like bleomy cin within the tumor, what could improve the effectiveness of treatment. This fusion of those two treatments is called electrochemotherapy. In this review, the authors will discuss the radiological perspective of possible beneficial role of irreversible electroporation in relation with chemotherapy in pancreatic cancer treatment.

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“…29 There is also debate over the strictness for R0 resection for patients with colorectal liver metastases. 30 Furthermore, application of next-generation technology to treat resection margins such as irreversible electroporation 31 may further support selective conservative resection of HC. Therefore, for patients with HC, it may be reasonable to avoid increasingly proximal resection and the risk of anastomotic leak or postoperative liver failure 15 as survival may be similar with the use of modern chemoradiotherapies.…”

Section: Discussionmentioning

confidence: 99%

Effect of Margin Status on Survival After Resection of Hilar Cholangiocarcinoma in the Modern Era of Adjuvant Therapies

Watson

Baimas-George

Passeri

et al. 2020

The American Surgeon™

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Introduction Studies have shown that for patients with hilar cholangiocarcinoma (HC), survival is associated with negative resection margins (R0). This requires increasingly proximal resection, putting patients at higher risk for complications, which may delay chemotherapy. For patients with microscopically positive resection margins (R1), the use of modern adjuvant therapies may offset the effect of R1 resection. Methods Patients at our institution with HC undergoing curative-intent resection between January 2008 and July 2019 were identified by retrospective record review. Demographic data, operative details, tumor characteristics, postoperative outcomes, recurrence, survival, and follow-up were recorded. Patients with R0 margin were compared to those with R1 margin. Patients with R2 resection were excluded. Results Seventy-five patients underwent attempted resection with 34 (45.3%) cases aborted due to metastatic disease or locally advanced disease. Forty-one (54.7%) patients underwent curative-intent resection with R1 rate of 43.9%. Both groups had similar rates of adjuvant therapy (56.5% vs. 61.1%, P = .7672). Complication rates and 30 mortality were similar between groups (all P > .05). Both groups had similar median recurrence-free survival (R0 29.2 months vs. R1 27.8 months, P = .540) and median overall survival (R0 31.2 months vs. R1 38.8 months, P = .736) with similar median follow-up time (R0 29.9 months vs. R1 28.5 months, P = .8864). Conclusions At our institution, patients undergoing hepatic resection for HC with R1 margins have similar recurrence-free and overall survival to those with R0 margins. Complications and short-term mortality were similar. This may indicate that with use of modern adjuvant therapies obtaining an R0 resection is not an absolute mandate.

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Application of Irreversible Electroporation Ablation as Adjunctive Treatment for Margin Enhancement: Safety and Efficacy

Cited by 13 publications

References 32 publications

Intratumoral electroporation of a self-amplifying RNA expressing IL-12 induces antitumor effects in mouse models of cancer

Intratumoral electroporation of a self-amplifying RNA expressing IL-12 induces antitumor effects in mouse models of cancer

Benefitial role of electrochemotherapy in locally advanced pancreatic cancer – radiological perspective

Effect of Margin Status on Survival After Resection of Hilar Cholangiocarcinoma in the Modern Era of Adjuvant Therapies

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