Application of Lanthanide-Doped Upconversion Nanoparticles for Cancer Treatment: A Review

Liu, Yuqi; Qin, Lu-Ping; Li, Hongjiao; Wang, Yixi; Zhang, Rui; Shi, Jiamin; Wu, Jihuai; Dong, Genxi; Zhou, Ping

doi:10.2217/nnm-2021-0214

Cited by 15 publications

(6 citation statements)

References 273 publications

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“…33 Combination therapy is also achievable with UCNPs, which can also carry other prodrugs, genes, or agents for PDT (Table 3). 34 For example, Kuang et al introduced poly-prodrug/siRNA-loaded UCNPs (PUCNP@Pt@siPLK1) with a hydrodynamic size of about 160 nm and a zeta-potential of about 10 mV. The PUCNP@Pt@siPLK1 had the capacities of tri-modal theranostics: imaging and NIR light-activated release of platinum(Pt)-based drug and gene for a multifunctional antitumor therapy (Fig.…”

Section: Inorganic Np-based Combination Therapymentioning

confidence: 99%

Organic and inorganic nanomedicine for combination cancer therapies

et al. 2023

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Section: Inorganic Np-based Combination Therapymentioning

confidence: 99%

Organic and inorganic nanomedicine for combination cancer therapies

et al. 2023

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“…In recent years, upconversion nanoparticles (UCNPs) have attracted attention for their ability to convert NIR light into visible light or ultraviolet light with a shorter wavelength ( 182 ). UCNPs have the advantages of minimizing light damage, deep tissue penetration, low light bleaching, and good chemical stability ( 183 – 185 ), which give them great potential for application in tumor therapy ( 186 ). Zhang et al ( 51 ) designed a lanthanide-doped UCNP nanotherapy platform (UCNPs@mSiO 2 FePc-MC540) coated with mesoporous silica for synergistic PDT and PTT, which included NaYF 4 :Yb, Er@NaLuF 4 :Nd@NaLuF 4 UCNPs, and dual photosensitizing agents (merocyanine 540 and iron phthalocyanine).…”

Section: Classification Of Photothermal Nanomaterialsmentioning

confidence: 99%

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

et al. 2022

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The aggressive growth of cancer cells brings extreme challenges to cancer therapy while triggering the exploration of the application of multimodal therapy methods. Multimodal tumor therapy based on photothermal nanomaterials is a new technology to realize tumor cell thermal ablation through near-infrared light irradiation with a specific wavelength, which has the advantages of high efficiency, less adverse reactions, and effective inhibition of tumor metastasis compared with traditional treatment methods such as surgical resection, chemotherapy, and radiotherapy. Photothermal nanomaterials have gained increasing interest due to their potential applications, remarkable properties, and advantages for tumor therapy. In this review, recent advances and the common applications of photothermal nanomaterials in multimodal tumor therapy are summarized, with a focus on the different types of photothermal nanomaterials and their application in multimodal tumor therapy. Moreover, the challenges and future applications have also been speculated.

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“…In recent decades, the up-converting luminescent materials based on lanthanide ions attracted much scientific interest due to their outstanding luminescence properties. The up-converting luminescent materials are widely used in a variety of applications, such as solar energy [1,2], anti-counterfeiting pigments [3], temperature sensors [4], fluorescence probes [5], bio-imaging [6], cancer therapeutics [7], etc. Usually, the inorganic up-converting luminescent materials contain at least two incorporated lanthanide ions: one as a sensitizer, typically Yb 3+ , and another as an emitter, such as Er 3+ [8,9], Ho 3+ [10][11][12][13], Tm 3+ [14][15][16], etc.…”

Section: Introductionmentioning

confidence: 99%

Up-Converting K2Gd(PO4)(WO4):20%Yb3+,Ho3+ Phosphors for Temperature Sensing

Grigorjevaite

Katelnikovas

2023

Materials

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Inorganic luminescent materials that can be excited with NIR radiation and emit in the visible spectrum have recently gained much scientific interest. Such materials can be utilized as anti-counterfeiting pigments, luminescent thermometers, bio-imaging agents, etc. In this work, we report the synthesis and optical properties of K2Gd(PO4)(WO4):Ho3+ and K2Gd(PO4)(WO4):20%Yb3+,Ho3+ powders. The single-phase samples were prepared by the solid-state reaction method, and the Ho3+ concentration was changed from 0.5% to 10% with respect to Gd3+. It is interesting to note that under 450 nm excitation, no concentration quenching was observed in K2Gd(PO4)(WO4):Ho3+ (at least up to 10% Ho3+) samples. However, adding 20% Yb3+ has caused a gradual decrease in Ho3+ emission intensity with an increase in its concentration. It turned out that this phenomenon is caused by the increasing probability of Ho3+ → Yb3+ energy transfer when Ho3+ content increases. K2Gd(PO4)(WO4):20%Yb3+,0.5%Ho3+ sample showed exceptionally high up-conversion (UC) emission stability in the 77–500 K range. The UC emission intensity reached a maximum at ca. 350 K, and the intensity at 500 K was around four times stronger than the intensity at 77 K. Moreover, the red/green emission ratio gradually increased with increasing temperature, which could be used for temperature sensing purposes.

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Application of Lanthanide-Doped Upconversion Nanoparticles for Cancer Treatment: A Review

Cited by 15 publications

References 273 publications

Organic and inorganic nanomedicine for combination cancer therapies

Organic and inorganic nanomedicine for combination cancer therapies

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

Up-Converting K2Gd(PO4)(WO4):20%Yb3+,Ho3+ Phosphors for Temperature Sensing

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