Application of laser CO2 for the treatment of xanthelasma palpebrarum

Navarro, C. Delgado; García, A. Lanuza; Cardeñosa, A. Llorca; Bañón-Navarro, R.; Martin, G. Corchero

doi:10.1016/j.oftale.2013.09.007

Cited by 5 publications

(7 citation statements)

References 5 publications

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“…Regarding cases` content, according to the rating given by the cases in their final visit about their overall content compared to the pre-therapy condition, Cases were contented with their results, rating them from good to excellent The adverse effects reported were pain, erythema, superficial crusting in (100%) of cases, edema in (60%) of cases, post LASER therapy scarring and post inflammatory hyperpigmentation or hypopigmentation in (40%) of cases. This finding agreed with the studies of Mourad et al [20] , Esmat et al [21] , Ullmann et al [22] , Apfelberg et al [23] and Delgado et al [24] . Mourad et al [20] reported post LASER CO 2 therapy side effects as: erythema in 5 cases, edema in 5 cases, hyperpigmentation in 2 cases and hypopigmentation in 3 cases.…”

Section: Discussionsupporting

confidence: 93%

Role of carbon dioxide laser in treatment of xanthelasma palpebrarum

Awara¹,

Neinaa²,

Shalaby³

et al. 2023

Int. J. Dermatol. Venereology Leprosy Sci.

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Background: Xanthelasma palpebrarum (XP) is the commonest form of xanthomas which develop over eye lids. Carbon dioxide (CO2) LASERs are considered the ideal therapy for xanthelasma. Objectives: The aim of this work was to evaluate the efficacy and safety of CO2 LASER in the therapy of XP. Methods: The current work was carried out on 15 cases presented with XP to be treated by CO2 LASER. For all cases, assessment of the degree of clinical improvement, cases' content and side effects were done. Results: Regarding assessment of the degree of clinical improvement, 11 xanthelasma cases (173-3%) showed excellent improvement, and 4 cases (26.7%) showed very good improvement. Regarding cases' content, 8 cases (53.3%) were very contented, 4 cases (26.7%) were contented, 2 cases (13.3%) were slightly contented, and one case (6.7%) was uncontented. Regarding side effects, all the 15 cases (100%) showed pain, erythema and superficial crustation, 9 cases (60%) showed edema and 5 cases (33.3%) showed scarring, 6 cases (40.0%) post inflammatory hyperpigmentation and no cases showed recurrence of the lesions during the follow up period. Conclusions: Carbon dioxide LASER is an excellent modality in the therapy of xanthelasma but its side effects must considered.

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Section: Discussionsupporting

confidence: 93%

Role of carbon dioxide laser in treatment of xanthelasma palpebrarum

Awara¹,

Neinaa²,

Shalaby³

et al. 2023

Int. J. Dermatol. Venereology Leprosy Sci.

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“…However, surgical management of xanthelasma remains difficult. Many methods to treat xanthelasma have been proposed, including cryotherapy, trichloroacetic acid peeling, electric cauterization, laser therapy (eg, carbon dioxide, argon, Q‐switched Nd:YAG, Er:YAG, and pulsed dye lasers), and surgical resection . However, none of these treatments have proven effective, and they can cause serious complications, including recurrence, scarring, and pigment alteration (hypo‐ or hyperpigmentation) .…”

Section: Introductionmentioning

confidence: 99%

Effect of a high‐cholesterol diet on lipoprotein metabolism and xanthoma formation in rabbits

Gao

Tang

et al. 2017

J of Cosmetic Dermatology

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Summary Background Xanthelasma is the most common type of cutaneous xanthoma and often occurs on the eyelids. Xanthoma has been reported to be highly correlated with abnormal lipoprotein metabolism. Aims In this study, we wanted to investigate the effects of a high‐cholesterol diet on xanthoma formation and lipoprotein metabolism in rabbits. Methods In animals fed with high‐cholesterol diet, deteced plasma lipid [ie, total cholesterol (TC), triglycerides (TG), and low‐density lipoprotein cholesterol (L‐DLC)] levels and pathology of xanthoma. Results Plasma lipid levels were dramatically elevated within 8 weeks. In addition, high dietary cholesterol promoted xanthoma formation on the napex. Microscopic examination showed that foam cells laden with cholesterol deposits accumulated around the dermal capillaries and cutaneous appendages within the skin of the napex. Conclusion These findings indicate a critical role for a high‐cholesterol diet in the dysregulation of lipoprotein metabolism and the development of xanthoma in rabbits. The results suggest that abnormal lipid metabolism may increase the occurrence of xanthoma.

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“…Reported adverse events typically included transient dyspigmentation, erythema, and scarring. Transient dyspigmentation was the most consistently reported adverse outcome, with hypopigmentation reported in 17 patients and hyperpigmentation reported in 10 patients . Mild erythema and edema were additional common complaints.…”

Section: Resultsmentioning

confidence: 97%

“…Studies included 1–50 patients for a total of 381 patients with xanthelasma palpebrarum discussed in the present review. Two studies reported inclusion of treatment naive patients, whereas another two reported washout periods of 12 weeks after previous treatments prior to initiating laser therapy . Otherwise, Most studies did not specify prior treatment history for the condition of interest.…”

Section: Resultsmentioning

confidence: 99%

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Systematic review of laser therapy in xanthelasma palpebrarum

2017

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Xanthelasma palpebrarum is a benign periorbital xanthoma with substantial cosmetic and psychosocial burden for patients. Treatment modalities should be considered based on efficacy as well as cosmetic outcome. Laser modalities in the treatment of xanthelasma palpebrarum have not been comprehensively reviewed and discussed. Accordingly, this study seeks to systematically and critically review the available literature discussing laser treatment of xanthelasma palpebrarum. PubMed was systematically reviewed for reports on laser therapy in the treatment of xanthelasma palpebrarum. A total of 21 studies were included in this review discussing laser treatment of xanthelasma palpebrarum. Laser types included carbon dioxide, yttrium aluminum garnet, pulsed dye, argon, and a 1450 nm diode laser. The carbon dioxide laser was the most commonly reported modality followed by yttrium aluminum garnet laser. All of the laser modalities offered moderate to excellent clearance rates with minimal side effect profiles. Further large scale studies comparing different laser modalities are required to determine the best laser modality. However, laser modalities as a whole offer a treatment option for xanthelasma palpebrarum, that is, cosmetically excellent with a reasonable side-effect profile.

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Application of laser CO2 for the treatment of xanthelasma palpebrarum

Cited by 5 publications

References 5 publications

Role of carbon dioxide laser in treatment of xanthelasma palpebrarum

Role of carbon dioxide laser in treatment of xanthelasma palpebrarum

Effect of a high‐cholesterol diet on lipoprotein metabolism and xanthoma formation in rabbits

Systematic review of laser therapy in xanthelasma palpebrarum

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