Application of magnetic iron oxide nanoparticles: Thrombotic activity, imaging and cytocompatibility of silica-coated and carboxymethyl dextrane-coated particles

Turrina, Chiara; Schoenen, Max; Milani, Davide; Klassen, A. J.; González, David; Cvirn, Gerhard; Mela, Petra; Berensmeier, Sonja; Slabu, Ioana; Schwaminger, Sebastian P.

doi:10.1016/j.colsurfb.2023.113428

Cited by 11 publications

(2 citation statements)

References 69 publications

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“…The most commonly synthesized magnetic nanoparticles for biomedical applications are iron oxide nanoparticles (IONPs) consisting of magnetite (Fe 3 O 4 ), maghemite (γ-Fe 2 O 3 ), hematite (α-Fe 2 O 3 ), or mixed ferrites [ 144 ]. The popularity of IONPs as drug carriers comes from their biocompatibility, non-toxicity, ease of preparation, and stability [ 145 , 146 , 147 ].…”

Section: Magnetic Nanoparticles As a Platform For Tumor-homing Peptidesmentioning

confidence: 99%

Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective

Milewska,

Sadowska,

Stefaniuk

et al. 2024

IJMS

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According to data from the World Health Organization (WHO), cancer is considered to be one of the leading causes of death worldwide, and new therapeutic approaches, especially improved novel cancer treatment regimens, are in high demand. Considering that many chemotherapeutic drugs tend to have poor pharmacokinetic profiles, including rapid clearance and limited on-site accumulation, a combined approach with tumor-homing peptide (THP)-functionalized magnetic nanoparticles could lead to remarkable improvements. This is confirmed by an increasing number of papers in this field, showing that the on-target peptide functionalization of magnetic nanoparticles improves their penetration properties and ensures tumor-specific binding, which results in an increased clinical response. This review aims to highlight the potential applications of THPs in combination with magnetic carriers across various fields, including a pharmacoeconomic perspective.

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Section: Magnetic Nanoparticles As a Platform For Tumor-homing Peptidesmentioning

confidence: 99%

Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective

Milewska,

Sadowska,

Stefaniuk

et al. 2024

IJMS

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“…With the gradual in-depth knowledge of the IONPs, the biocompatibility and toxicity of IONPs are primary determined by their size, while their surface coating molecules and functional group profoundly influence the bio-interaction between IONPs and biological system [ 12 , 13 ]. It was reported that the coating material and thickness impact on the degradation rate and prothrombotic activity of IONPs [ 14 ]. The results showed that carboxymethyl dextran coated IONPs degraded faster in simulated body fluid than those coated with silica, and showed the least prothrombotic properties.…”

Section: Introductionmentioning

confidence: 99%

Recent trends in preparation and biomedical applications of iron oxide nanoparticles

Meng,

Shi,

Zhu

et al. 2024

J Nanobiotechnol

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The iron oxide nanoparticles (IONPs), possessing both magnetic behavior and semiconductor property, have been extensively used in multifunctional biomedical fields due to their biocompatible, biodegradable and low toxicity, such as anticancer, antibacterial, cell labelling activities. Nevertheless, there are few IONPs in clinical use at present. Some IONPs approved for clinical use have been withdrawn due to insufficient understanding of its biomedical applications. Therefore, a systematic summary of IONPs’ preparation and biomedical applications is crucial for the next step of entering clinical practice from experimental stage. This review summarized the existing research in the past decade on the biological interaction of IONPs with animal/cells models, and their clinical applications in human. This review aims to provide cutting-edge knowledge involved with IONPs’ biological effects in vivo and in vitro, and improve their smarter design and application in biomedical research and clinic trials. Graphical Abstract

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Enhancing biomedical imaging: the role of nanoparticle-based contrast agents

Habeeb,

Vengateswaran,

Tripathi

et al. 2024

Biomed Microdevices

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Application of magnetic iron oxide nanoparticles: Thrombotic activity, imaging and cytocompatibility of silica-coated and carboxymethyl dextrane-coated particles

Cited by 11 publications

References 69 publications

Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective

Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective

Recent trends in preparation and biomedical applications of iron oxide nanoparticles

Enhancing biomedical imaging: the role of nanoparticle-based contrast agents

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