Application of Magnetic Resonance Strain Analysis Using Feature Tracking in a Myocardial Infarction Model

Abstract

This study validates the usefulness of myocardial strain analysis with cardiac cine magnetic resonance imaging (MRI) by evaluating the changes in the cardiac function and myocardial strain values longitudinally in a myocardial disease model. Six eight-week-old male Wistar rats were used as a model of myocardial infarction (MI). Cine images were taken in the short axis, two-chamber view longitudinal axis, and four-chamber view longitudinal axis directions in rats 3 and 9 days after MI and in control rats, with preclinical 7-T MRI. The control images and the images on days 3 and 9 were evaluated by measuring the ventricular ejection fraction (EF) and the strain values in the circumferential (CS), radial (RS), and longitudinal directions (LS). The CS decreased significantly 3 days after MI, but there was no difference between the images on days 3 and 9. The two-chamber view LS was −9.7 ± 2.1% at 3 days and −13.9 ± 1.4% at 9 days after MI. The four-chamber view LS was −9.9 ± 1.5% at 3 days and −11.9 ± 1.3% at 9 days after MI. Both the two- and four-chamber LS values were significantly decreased 3 days after MI. Myocardial strain analysis is, therefore, useful for assessing the pathophysiology of MI.

Preclinical magnetic resonance imaging and spectroscopy in the fields of radiological technology, medical physics, and radiology

“…Also, MRI can provide high-resolution images of the heart and surrounding structures, allowing for detailed analysis of cardiac function, morphology, and tissue composition. For assessment of cardiac function, MRI can be used to assess various aspects of cardiac function, such as cardiac output, left-ventricular ejection fraction, and myocardial strain [ 16 , 17 , 33 , 34 , 61 ] (Fig. 5 F) Furthermore, MRI can be used to characterize various aspects of cardiac tissue, such as fibrosis, inflammation, and lipid deposition for characterization of cardiac tissue.…”

“…Cardiovascular magnetic resonance (CMR) imaging has recently attracted attention in the evaluation of MI and cardiac function and myocardial tissue-level characteristics. Onishi et al [ 33 ] performed that CMR of MI model rats was acquired on days 3 and 9 after MI using preclinical 7 T MRI, and cardiac function and myocardial strain values were calculated (Fig. 8 and Fig.…”

Conditions for late gadolinium enhancement MRI in myocardial infarction model rats that better reflect microscopic tissue staining

“…It can provide a variety of information such as cardiac function 9 , relaxation time measurement 10,11 , strain analysis 12,13 , and flow velocity measurement 14,15 . In the clinical setting, CMR has also been used in preclinical studies on the animal heart [16][17][18][19][20][21] . One CMR technique that highlights the area of myocardial injury is late gadolinium enhancement (LGE).…”