Application of marine collagen for stem‑cell‑based therapy and tissue regeneration (Review)

Abstract

tissue engineering and regenerative medicine is becoming an important component in modern biological scientific research. tissue engineering, a branch of regenerative medicine, is a field that is actively developing to meet the challenges presented in biomedical applications. this particularly applies to the research area of stem cells and biomaterials, due to both being pivotal determinants for the successful restoration or regeneration of damaged tissues and organs. Recently, the development of innovative marine collagen-based biomaterials has attracted attention due to the reported environmentally friendly properties, the lack of zoonotic disease transmission, biocompatibility, bioactivity, the lack of ethics-related concerns and cost-effectiveness for manufacturing. the present review aimed to summarize the potential application and function of marine collagen in stem cell research in a medical and clinical setting. In addition, the present review cited recent studies regarding the latest research advances into using marine collagen for cartilage, bone, periodontal and corneal regeneration. It also characterized the distinct advantages of using marine collagen for stem cell-based tissue repair and regeneration. In addition, the present review comprehensively discussed the most up to date information on stem cell biology, particularly the possibility of treating stem cells with marine collagen to maximize their multi-directional differentiation capability, which highlights the potential use of marine collagen in regenerative medicine. Furthermore, recent research progress on the potential immunomodulatory capacity of mesenchymal stem cells following treatment with marine collagen to improve the understanding of cell-matrix interactions was investigated. Finally, perspectives on the possible future research directions for the application of marine collagen in the area of regenerative medicine are provided.

Layer-by-Layer Coatings of Collagen–Hyaluronic acid Loaded with an Antibacterial Manuka Honey Bioactive Compound to Fight Metallic Implant Infections

“…There is still limited literature regarding MGO’s role in the calcification of bone cells, yet research has reported that MGO generates mitochondrial dysfunction in liver cells . It has been reported that certain collagen amino acids, such as glycine, alanine, glutamine, and asparagine, can selectively induce osteogenesis by activating the focal adhesion kinase/JNK signaling cascade and runt-related transcription factors in bone marrow-derived MSCs . Rena et al proved that the enhanced rates of fibril production by tilapia-scale COLL may promote early osteogenic induction via upregulating alp , opn , and bmp-2.…”

Evaluation of the biocompatibility of fish skin collagen with the mesenchymal stem cells in in vitro cultures

“…Freeze-dried collagen was dissolved in acetic acid (0.1 mol L −1 ) by the way of continuous stirring for 5 h at room temperature (RT). Collagen stock solution was prepared by adding chloroform to the mixture in proportion 1:9, the resulting solution was stored overnight at +4 °C.…”

“…Collagen ranks as one of the most widely studied naturally occurring polymers and as a major component of the extracellular matrix of connective tissues such as bones, cartilage, ligaments and skin. 1 As the most ubiquitous protein in the mammalian body, collagen plays a key role in the formation of organs and tissues and is considered to be an appropriate scaffold for maintaining cell culture proliferation. Other aspects of cell behavior affected by collagen are cell adhesion, differentiation, proliferation, and cellular migration, so it makes it an ideal material for cell culture research.…”

Recovery of Bioactive Compounds from Marine Organisms: Focus on the Future Perspectives for Pharmacological, Biomedical and Regenerative Medicine Applications of Marine Collagen

“…These marine polymers are multifunctional, with a range of therapeutic uses, from anti-inflammatory to antiviral purposes [ 31 ]. Among many natural polymers, including chitin and alginates, collagen is one of the most extensively studied and applied polymers in clinical settings, because of its properties [ 32 ]. It plays a fundamental role in the formation of tissues and organs and it is involved in various functional and structural aspects of cells.…”