Application of marrow mesenchymal stem cell-derived extracellular matrix in peripheral nerve tissue engineering

Gu, Yun; Li, Zhenmeiyu; Huang, Jiejie; Wang, Hongkui; Gu, Xiaosong; Gu, Jianhui

doi:10.1002/term.2123

Cited by 51 publications

(23 citation statements)

References 41 publications

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“…In contrast, part of synthetic polymers can produce acidic materials during degradation which is detrimental to the microenvironment and cellular activity [ 133 ]. The internal structure within the basal lamina is beneficial for axonal guidance compared with hollow lumen tubes, which are composed of organized multiple fibers [ 128 , 129 ] or less orderly collagen sponges [ 125 ].…”

Section: Stem Cell Deliverymentioning

confidence: 99%

Stem Cell Transplantation for Peripheral Nerve Regeneration: Current Options and Opportunities

Jiang

Jones

Jia

2017

IJMS

172

163

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Peripheral nerve regeneration is a complicated process highlighted by Wallerian degeneration, axonal sprouting, and remyelination. Schwann cells play an integral role in multiple facets of nerve regeneration but obtaining Schwann cells for cell-based therapy is limited by the invasive nature of harvesting and donor site morbidity. Stem cell transplantation for peripheral nerve regeneration offers an alternative cell-based therapy with several regenerative benefits. Stem cells have the potential to differentiate into Schwann-like cells that recruit macrophages for removal of cellular debris. They also can secrete neurotrophic factors to promote axonal growth, and remyelination. Currently, various types of stem cell sources are being investigated for their application to peripheral nerve regeneration. This review highlights studies involving the stem cell types, the mechanisms of their action, methods of delivery to the injury site, and relevant pre-clinical or clinical data. The purpose of this article is to review the current point of view on the application of stem cell based strategy for peripheral nerve regeneration.

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Section: Stem Cell Deliverymentioning

confidence: 99%

Stem Cell Transplantation for Peripheral Nerve Regeneration: Current Options and Opportunities

Jiang

Jones

Jia

2017

IJMS

172

163

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“…98,99 Various studies have investigated the efficacy of introducing ECM proteins as NGC luminal wall coating. Laminin is the most frequently used ECM protein for the surface modification of neural scaffolds, and has ultimately led to improved Schwann cell viability in in vitro assays and nerve regeneration in vivo using a 10–12 mm rat sciatic gap injury model.…”

Section: Scaffold Surface Modificationsmentioning

confidence: 99%

Biomimetic neural scaffolds: a crucial step towards optimal peripheral nerve regeneration

et al. 2018

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Peripheral nerve injury is a common disease that affects more than 20 million people in the United States alone and remains a major burden to society. The current gold standard treatment for critical-sized nerve defects is autologous nerve graft transplantation; however, this method is limited in many ways and does not always lead to satisfactory outcomes. The limitations of autografts have prompted investigations into artificial neural scaffolds as replacements, and some neural scaffold devices have progressed to widespread clinical use; scaffold technology overall has yet to be shown to be consistently on a par with or superior to autografts. Recent advances in biomimetic scaffold technologies have opened up many new and exciting opportunities, and novel improvements in material, fabrication technique, scaffold architecture, and lumen surface modifications that better reflect biological anatomy and physiology have independently been shown to benefit overall nerve regeneration. Furthermore, biomimetic features of neural scaffolds have also been shown to work synergistically with other nerve regeneration therapy strategies such as growth factor supplementation, stem cell transplantation, and cell surface glycoengineering. This review summarizes the current state of neural scaffolds, highlights major advances in biomimetic technologies, and discusses future opportunities in the field of peripheral nerve regeneration.

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“…Functionally scaffolds modified with cell-derived extracellular matrix (ECM) have been developed; some studies also used ECM derived from terminally differentiated cells, stem cells to explore the developmental rules of stem cell osteogenesis, adipogenesis and differentiation into nerve cells [ 8–11 ]. Gu et al [ 12 ] used Schwann cell-derived ECM-modified chitosan/silk fibroin (SF) for bridging rat sciatic nerve gaps.…”

Section: Introductionmentioning

confidence: 99%

Cell-derived extracellular matrix-coated silk fibroin scaffold for cardiogenesis of brown adipose stem cells through modulation of TGF-β pathway

Liu

Sun

Dong

et al. 2020

Regenerative Biomaterials

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The cell-derived extracellular matrix (ECM)-modified scaffolds have advantages of mimic tissue specificity and been thought to better mimic the native cellular microenvironment in vitro. ECM derived from cardiac fibroblasts (CFs) are considered as key elements that provide a natural cell growth microenvironment and change the fate of cardiomyocytes (CMs). Here, a new hybrid scaffold is designed based on silk fibroin (SF) scaffold and CFs-derived ECM. CFs were seeded on the SF scaffold for 10 days culturing and decellularized to produce CFs-derived ECM-coated SF scaffold. The results showed that the cell-derived ECM-modified silk fibroin scaffold material contained collagen, laminin, fibronectin and other ECM components with myocardial-like properties. Further to explore its effects on brown adipose stem cells (BASCs) differentiation into CMs. We found that the CF-derived ECM-coated scaffold also increased the expression of CM-specific proteins (e.g. cardiac troponin T and α-actinin) of BASCs. Notably, the β1-integrin-dependent transforming growth factor-β1 signaling pathway was also involved in the regulation of CF-derived ECM by promoting the differentiation of BASCs into CMs. Overall, these findings provide insights into the bionic manufacturing of engineered cardiac tissues (ECTs) and establish a theoretical basis for the construction of ECTs.

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Application of marrow mesenchymal stem cell-derived extracellular matrix in peripheral nerve tissue engineering

Cited by 51 publications

References 41 publications

Stem Cell Transplantation for Peripheral Nerve Regeneration: Current Options and Opportunities

Stem Cell Transplantation for Peripheral Nerve Regeneration: Current Options and Opportunities

Biomimetic neural scaffolds: a crucial step towards optimal peripheral nerve regeneration

Cell-derived extracellular matrix-coated silk fibroin scaffold for cardiogenesis of brown adipose stem cells through modulation of TGF-β pathway

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