Application of materials as medical devices with localized drug delivery capabilities for enhanced wound repair

Abstract

The plentiful assortment of natural and synthetic materials can be leveraged to accommodate diverse wound types, as well as different stages of the healing process. An ideal material is envisioned to promote tissue repair with minimal inconvenience for patients. Traditional materials employed in the clinical setting often invoke secondary complications, such as infection, pain, foreign body reaction, and chronic inflammation. This review surveys the repertoire of surgical sutures, wound dressings, surgical glues, orthopedic fixation devices and bone fillers with drug eluting capabilities. It highlights the various techniques developed to effectively incorporate drugs into the selected material or blend of materials for both soft and hard tissue repair. The mechanical and chemical attributes of the resultant materials are also discussed, along with their biological outcomes in vitro and/or in vivo. Perspectives and challenges regarding future research endeavors are also delineated for next-generation wound repair materials.

Antimicrobial Peptide‐Based Electrospun Fibers for Wound Healing Applications

“…The release profile of the inducer had an initial burst of about half of the loaded drug followed by an almost complete release over 30 days, which is acceptable for the healing time frame of an acute wound . These studies demonstrate that AMP burst release can be circumvented by the format that the loaded AMP is incorporated into ESFs, while still achieving improved wound healing, similar to other technologies …”

“…Currently several different approaches using varying types of antimicrobials and different antiseptic techniques are being developed ( Figure 2 ). Numerous bioactive molecules have been investigated in great detail with mixed success but some alternatives are already reaching consumers …”

“…These factors, and more, should be the primary driving force behind designing different antimicrobial/polymer systems to ensure the dressing performs optimally for patient quality of care …”

Effect of hyaluronic acid added to suture material and its relationship with bacterial colonization: An in vitro study

“…Further studies may be necessary to compare and combine different anti-wicking methods to further reduce the incidence of inflammation at the site of infection. The need to consider the principles of local delivery of drugs and to incorporate similar technology;[ 21 ] in suture, material might give promising results. Furthermore, research in the role of immune mechanisms needs to be considered as it can give better information about the role of specific suture materials in different conditions.…”

Controllable Drug Release Behavior of Polylactic Acid (PLA) Surgical Suture Coating with Ciprofloxacin (CPFX)—Polycaprolactone (PCL)/Polyglycolide (PGA)

“…However, those drugs, which are applied throughout the body, have some great side-effects on human's tissues and organs. Therefore, it is a straightforward and effective method to load the drugs on the PLA suture, which can release the drug directly to the wound [10][11][12].…”