Application of mathematical modeling to quantify ventricular contribution following durable left ventricular assist device support

Vasudevan, Viswajith Siruvallur; Rajagopal, Keshava; Antaki, James F.

doi:10.1016/j.apples.2022.100107

Cited by 4 publications

(4 citation statements)

References 42 publications

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“…In comparison, the trend in Fig. 5(B), an important factor in overall LVEF decreasing slightly is likely due to the unimodal ESPVR used in the study alongwith the VAD speed reduction induced LV distension 11,15 .…”

Section: Response Lvef and Tavef To Reduced Vad Speedmentioning

confidence: 86%

“…The dependent variables employed to assess ventricular function, hence recovery, are derived from the state variables of the model and include stroke volume (SV), LVEF, and TAVEF as defined in our previous work 11,26 . The left ventricular stroke volume, SVLV, is defined using the traditional formula as the difference between end-diastolic and end-systolic ventricular volume, EDV, ESV, respectively:…”

Section: Recovery Assessment Using Sos -Dependent Variablesmentioning

confidence: 99%

“…The model distinguishes systemic arterial blood flow due to blood within the LV being ejected across the aortic valve, from systemic arterial blood flow due to blood within the LV flowing through the LVAD system. Our previous work demonstrated how this flow division is affected by pump speed 11 . We also introduced a new metric of LV contribution, TAVEF, the Trans-Aortic Valvular Ejection Fraction, which provides a measure of native LV systolic function function independent of LVAD contribution.…”

Section: Introductionmentioning

confidence: 95%

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Trans-Aortic Valvular Flow Dynamics and Left Ventricular Ejection Fraction for Monitoring Recovery of Patients With Left Ventricular Systolic Heart Failure

Vasudevan

Rajagopal

Rame

et al. 2023

Preprint

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Durable mechanical circulatory support in the form of left ventricular (LV) assist device (LVAD) therapy is increasingly considered in the context of the recovery of native cardiac function. Progressive improvement in LV function may facilitate LVAD explantation and a resultant reduction in device-related risk. However, ascertaining LV recovery remains a challenge. In this study, we investigated the use of trans-aortic valvular flow rate and trans-LVAD flow rate to assess native LV systolic function using a well-established lumped parameter model of the mechanically assisted LV with pre-existing systolic dysfunction. Trans Aortic Valvular Ejection Fraction (TAVEF) was specifically found to characterize the preload-independent contractility of the LV. It demonstrated excellent sensitivity to simulated pharmacodynamic stress tests and volume infusion tests. TAVEF may prove to be useful in the ascertainment of LV recovery in LVAD-supported LVs with pre-existing LV systolic dysfunction.

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Section: Response Lvef and Tavef To Reduced Vad Speedmentioning

confidence: 86%

Section: Recovery Assessment Using Sos -Dependent Variablesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Trans-Aortic Valvular Flow Dynamics and Left Ventricular Ejection Fraction for Monitoring Recovery of Patients With Left Ventricular Systolic Heart Failure

Vasudevan

Rajagopal

Rame

et al. 2023

Preprint

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show abstract

“…The right and left ventricles are modelled as variable capacitors to calculate the relationship of pressure, volume and time, as well as viscous losses due to their characteristic flexibility and activation function. The time-dependent end-diastolic elastance (its hardness) of the right and left ventricles is shown in Ed, equation 1 with its general expression [12].…”

Section: Methodsmentioning

confidence: 99%

The New HEMS Modelling of Human Heart

KIZILKAPLAN

Yalcinkaya

2022

Balkan Journal of Electrical and Computer Engineering

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The new version of the hydro-electro-mechanical system (HEMS) is modeled via 14 serially connected electrical equivalent circuits resulting in an integrated equivalent circuit. The new model accepts a group of variables and even examines the interaction between them. This paper introduces an improved integrated new model of the heart by replacing the monolithic equivalent structures with segmental comprehensive equivalents. Windkessel Model (WM) is a model of the relationships between aorta, aortic valve and left ventricle. Based on WM, the integrated new model was developed and simulated. The model’s main focus is to define the dynamic properties of the system by a set of ordinary differential equations, and solving them using Ode23, a method for the solution of a closed-loop system. Using Matlab based Ode23 method; time-dependency of pressure, volume and flow were obtained. In case, short computation time and high accuracy are needed, then ode23 is used. The model may be used to analyze complex processes in the heart and blood vessels. The new HEMS model has potential use for hemodynamic simulation of diseases, cardiovascular disorders, and special congenital heart diseases; such as ASD, VSD and PDA.

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Introduction to advances in cardiovascular science

Rajagopal¹

2023

Applications in Engineering Science

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Application of mathematical modeling to quantify ventricular contribution following durable left ventricular assist device support

Cited by 4 publications

References 42 publications

Trans-Aortic Valvular Flow Dynamics and Left Ventricular Ejection Fraction for Monitoring Recovery of Patients With Left Ventricular Systolic Heart Failure

Trans-Aortic Valvular Flow Dynamics and Left Ventricular Ejection Fraction for Monitoring Recovery of Patients With Left Ventricular Systolic Heart Failure

The New HEMS Modelling of Human Heart

Introduction to advances in cardiovascular science

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