Application of mesenchymal stem cells in corneal regeneration

Ghiasi, Mohsen; Jadidi, Khosrow; Hashemi, Mehrdad; Zare, Hamed; Salimi, Ali; Aghamollaei, Hossein

doi:10.1016/j.tice.2021.101600

Cited by 18 publications

(9 citation statements)

References 124 publications

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“…In line with these findings are results obtained in several experimental and clinical studies which demonstrated the capacity of MSC to repair and regenerate the injured corneal epithelium, meibomian and lacrimal glands, indicating their therapeutic potential in the treatment of oGVHD [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Msc-mediated Tissue Repair and Regeneration: A New Hope For ...supporting

confidence: 71%

“…In addition to MSC, pluripotent stem cells (embryonic stem cells (ESC) and induced pluripotent stem cells (iPSCs)) were also explored as a potentially valuable cell source for the repair and regeneration of injured epithelial cells of oGVHD patients [ 9 , 12 ]. Under specific culture conditions, MSC, ESCs, and iPSCs had a similar potential for differentiation towards corneal epithelial cells [ 9 , 12 ]. Importantly, compared to ESCs and iPSCs, MSC showed a superior potential for the immunoregulation and suppression of the detrimental immune response in the eyes of oGVHD patients [ 20 ].…”

Section: Safety Issues Related To the Transplantation Of Msc In The E...mentioning

confidence: 99%

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Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Ocular Graft-Versus-Host Disease

Harrell¹,

Djonov

Volarević

2022

IJMS

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Ocular GVHD (oGVHD), manifested by severe injury of corneal epithelial cells, meibomian and lacrimal glands’ dysfunction, is a serious complication of systemic GVHD which develops as a consequence of donor T and natural killer cell-driven inflammation in the eyes of patients who received allogeneic hematopoietic stem cell transplantation. Mesenchymal stem cells (MSC) are, due to their enormous differentiation potential and immunosuppressive characteristics, considered as a potentially new remedy in ophthalmology. MSC differentiate in corneal epithelial cells, suppress eye inflammation, and restore meibomian and lacrimal glands’ function in oGVHD patients. MSC-sourced exosomes (MSC-Exos) are extracellular vesicles that contain MSC-derived growth factors and immunoregulatory proteins. Due to the lipid membrane and nano-sized dimension, MSC-Exos easily by-pass all biological barriers in the eyes and deliver their cargo directly in injured corneal epithelial cells and eye-infiltrated leukocytes, modulating their viability and function. As cell-free agents, MSC-Exos address all safety issues related to the transplantation of their parental cells, including the risk of unwanted differentiation and aggravation of intraocular inflammation. In this review article, we summarized current knowledge about molecular mechanisms which are responsible for beneficial effects of MSC and MSC-Exos in the therapy of inflammatory eye diseases, emphasizing their therapeutic potential in the treatment of oGVHD.

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Section: Msc-mediated Tissue Repair and Regeneration: A New Hope For ...supporting

confidence: 71%

Section: Safety Issues Related To the Transplantation Of Msc In The E...mentioning

confidence: 99%

Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Ocular Graft-Versus-Host Disease

Harrell¹,

Djonov

Volarević

2022

IJMS

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“…Mesenchymal stem cells (MSCs) that can differentiate into distinct cell types, secrete growth factors, have mobilization potential, and can be obtained from various sources; have received particular attention in corneal engineering (Ghiasi et al, 2021). Previously, allogeneic grafts by culturing human adipose derived stem cells (hADSCs) and Wharton's Jellyderived mesenchymal stem cells on the acellular human stromal sheets was reported (Aghamollaei et al, 2021;Jorge L Alio del Barrio et al, 2015). The follow-up results showed safety and transparency in graft bio-integration and did not show any sign of clinical rejection.…”

Section: Scaffold-based Methodsmentioning

confidence: 99%

“…Currently, different cell types have been seeded on various kinds of scaffolds and utilized for tissue regeneration. Mesenchymal stem cells (MSCs) that can differentiate into distinct cell types, secrete growth factors, have mobilization potential, and can be obtained from various sources; have received particular attention in corneal engineering (Ghiasi et al., 2021). Previously, allogeneic grafts by culturing human adipose derived stem cells (hADSCs) and Wharton's Jelly‐derived mesenchymal stem cells on the acellular human stromal sheets was reported (Aghamollaei et al., 2021; Jorge L Alio del Barrio et al., 2015).…”

Section: Scaffold‐based Methodsmentioning

confidence: 99%

Emerging tissue engineering strategies for the corneal regeneration

Tafti

Aghamollaei

Moghaddam

et al. 2022

J Tissue Eng Regen Med

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Cornea as the outermost layer of the eye is at risk of various genetic and environmental diseases that can damage the cornea and impair vision. Corneal transplantation is among the most applicable surgical procedures for repairing the defected tissue. However, the scarcity of healthy tissue donations as well as transplantation failure has remained as the biggest challenges in confront of corneal grafting. Therefore, alternative approaches based on stem-cell transplantation and classic regenerative medicine have been developed for corneal regeneration. In this review, the application and limitation of the recently-used advanced approaches for regeneration of cornea are discussed. Additionally, other emerging powerful techniques such as 5D printing as a new branch of scaffold-based technologies for construction of tissues other than the cornea are highlighted and suggested as alternatives for corneal reconstruction. The introduced novel techniques may have great potential for clinical applications in corneal repair including disease modeling, 3D pattern scheming, and personalized medicine.

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“…Another major drawback in the use of cell therapy arises in the different methods used for the isolation and culture of cell lineages, which leads to different results [ 36 ]. Finally, several other studies demonstrated that MSCs lack “immune privilege”, so they may not be sufficiently safe, although this aspect is considered to be negligible in the case of the corneal tissue that is self-immune privileged [ 37 , 38 , 39 ]. In light of these limitations, the research is still ongoing to perfect cell therapy.…”

Section: Introductionmentioning

confidence: 99%

Alginate-Based Composites for Corneal Regeneration: The Optimization of a Biomaterial to Overcome Its Limits

Tarsitano

Cristiano

Fresta

et al. 2022

Gels

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For many years, corneal transplantation has been the first-choice treatment for irreversible damage affecting the anterior part of the eye. However, the low number of cornea donors and cases of graft rejection highlighted the need to replace donor corneas with new biomaterials. Tissue engineering plays a fundamental role in achieving this goal through challenging research into a construct that must reflect all the properties of the cornea that are essential to ensure correct vision. In this review, the anatomy and physiology of the cornea are described to point out the main roles of the corneal layers to be compensated and all the requirements expected from the material to be manufactured. Then, a deep investigation of alginate as a suitable alternative to donor tissue was conducted. Thanks to its adaptability, transparency and low immunogenicity, alginate has emerged as a promising candidate for the realization of bioengineered materials for corneal regeneration. Chemical modifications and the blending of alginate with other functional compounds allow the control of its mechanical, degradation and cell-proliferation features, enabling it to go beyond its limits, improving its functionality in the field of corneal tissue engineering and regenerative medicine.

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Application of mesenchymal stem cells in corneal regeneration

Cited by 18 publications

References 124 publications

Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Ocular Graft-Versus-Host Disease

Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Ocular Graft-Versus-Host Disease

Emerging tissue engineering strategies for the corneal regeneration

Alginate-Based Composites for Corneal Regeneration: The Optimization of a Biomaterial to Overcome Its Limits

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