Application of Microbiome-Based Therapies in Chronic Respiratory Diseases

Lee, Se Hee; Lee, Jang Ho; Lee, Sei Won

doi:10.1007/s12275-024-00124-1

J Microbiol.

2024

DOI: 10.1007/s12275-024-00124-1

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Application of Microbiome-Based Therapies in Chronic Respiratory Diseases

Se Hee Lee,

Jang Ho Lee,

Sei Won Lee

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2024

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Cited by 3 publications

(1 citation statement)

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“…This review highlights recent advancements in cosmetic products designed to preserve and enhance microbial diversity through prebiotics, probiotics, and postbiotics and explores the connection between gut health and skin conditions. Lee et al (2024b) focused on the potential of microbiome-based therapies for treating chronic respiratory diseases, highlighting the limitations of current treatments and the dynamic nature of the lung microbiome. It explores how altering the gut microbiome and administering metabolites can improve chronic respiratory conditions.…”

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confidence: 99%

Host-Associated Microbiome

Sul

2024

J Microbiol.

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mentioning

confidence: 99%

Host-Associated Microbiome

Sul

2024

J Microbiol.

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The emerging roles of microbiome and short-chain fatty acids in the pathogenesis of bronchopulmonary dysplasia

Gao,

Wang,

Lin

et al. 2024

Front. Cell. Infect. Microbiol.

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Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects premature infants and leads to long-term pulmonary complications. The pathogenesis of BPD has not been fully elucidated yet. In recent years, the microbiome and its metabolites, especially short-chain fatty acids (SCFAs), in the gut and lungs have been demonstrated to be involved in the development and progression of the disease. This review aims to summarize the current knowledge on the potential involvement of the microbiome and SCFAs, especially the latter, in the development and progression of BPD. First, we introduce the gut-lung axis, the production and functions of SCFAs, and the role of SCFAs in lung health and diseases. We then discuss the evidence supporting the involvement of the microbiome and SCFAs in BPD. Finally, we elaborate on the potential mechanisms of the microbiome and SCFAs in BPD, including immune modulation, epigenetic regulation, enhancement of barrier function, and modulation of surfactant production and the gut microbiome. This review could advance our understanding of the microbiome and SCFAs in the pathogenesis of BPD, which also helps identify new therapeutic targets and facilitate new drug development.

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Bacteria and Allergic Diseases

Guryanova

2024

IJMS

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Microorganisms colonize all barrier tissues and are present on the skin and all mucous membranes from birth. Bacteria have many ways of influencing the host organism, including activation of innate immunity receptors by pathogen-associated molecular patterns and synthesis of various chemical compounds, such as vitamins, short-chain fatty acids, bacteriocins, toxins. Bacteria, using extracellular vesicles, can also introduce high-molecular compounds, such as proteins and nucleic acids, into the cell, regulating the metabolic pathways of the host cells. Epithelial cells and immune cells recognize bacterial bioregulators and, depending on the microenvironment and context, determine the direction and intensity of the immune response. A large number of factors influence the maintenance of symbiotic microflora, the diversity of which protects hosts against pathogen colonization. Reduced bacterial diversity is associated with pathogen dominance and allergic diseases of the skin, gastrointestinal tract, and upper and lower respiratory tract, as seen in atopic dermatitis, allergic rhinitis, chronic rhinosinusitis, food allergies, and asthma. Understanding the multifactorial influence of microflora on maintaining health and disease determines the effectiveness of therapy and disease prevention and changes our food preferences and lifestyle to maintain health and active longevity.

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Application of Microbiome-Based Therapies in Chronic Respiratory Diseases

Cited by 3 publications

References 113 publications

Host-Associated Microbiome

Host-Associated Microbiome

The emerging roles of microbiome and short-chain fatty acids in the pathogenesis of bronchopulmonary dysplasia

Bacteria and Allergic Diseases

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