2013
DOI: 10.1002/jat.2857
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Application of microPET imaging approaches in the study of pediatric anesthetic‐induced neuronal toxicity

Abstract: Advances in pediatric and obstetric surgery have resulted in an increase in the complexity, duration and number of anesthetic procedures. Currently, the general anesthetics that are used most often have either NMDA receptor blocking or GABA receptor activating properties. It has been reported that prolonged exposure of the developing brain to a clinically relevant concentration of anesthetics that have NMDA antagonist or GABA-mimetic properties, and/or their combinations, resulted in an extensive abnormal patt… Show more

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Cited by 22 publications
(13 citation statements)
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“…TSPO is recognized as an PET Imaging of [ 18 F]-FEPPA in the Nonhuman Primate important surrogate of associated neurotoxicity, which can be monitored using PET imaging using appropriate radioligands such as [ 18 F]-FEPPa. 40,41,43 in the current study, [ 18 F]-FEPPa was used to repeatedly visualize and quantify, in the same animal, aspects of possible adverse neuronal effects associated with developmental exposure to sevoflurane. increased accumulation of [ 18 F]-FEPPa was interpreted as increased levels of TSPO expression, representing neuroinflammation induced by neuronal insults, such as sevoflurane exposure.…”
Section: Perioperative Medicinementioning
confidence: 99%
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“…TSPO is recognized as an PET Imaging of [ 18 F]-FEPPA in the Nonhuman Primate important surrogate of associated neurotoxicity, which can be monitored using PET imaging using appropriate radioligands such as [ 18 F]-FEPPa. 40,41,43 in the current study, [ 18 F]-FEPPa was used to repeatedly visualize and quantify, in the same animal, aspects of possible adverse neuronal effects associated with developmental exposure to sevoflurane. increased accumulation of [ 18 F]-FEPPa was interpreted as increased levels of TSPO expression, representing neuroinflammation induced by neuronal insults, such as sevoflurane exposure.…”
Section: Perioperative Medicinementioning
confidence: 99%
“…69-71 [ 18 F]-FEPPa is a specific TSPO ligand that can be efficiently synthesized at high radiochemical yields with high specific activity that has proven useful in nonhuman primate studies. 40,41,43,47,[72][73][74] due to the increased expression of TSPOs in areas of neuronal injury/ neurotoxicity, [ 18 F]-FEPPa can be used as a marker for microglial activation and an indirect marker for neuronal damage, injury, and neurotoxicity. TSPO is recognized as an PET Imaging of [ 18 F]-FEPPA in the Nonhuman Primate important surrogate of associated neurotoxicity, which can be monitored using PET imaging using appropriate radioligands such as [ 18 F]-FEPPa.…”
Section: Perioperative Medicinementioning
confidence: 99%
See 1 more Smart Citation
“…In our studies, micro positron emission tomography (microPET) is utilized to depict the neuronal apoptosis and inflammatory alterations following neonatal exposure to anesthetics in vivo ( 39 41 ). A minimally invasive imaging modality, PET coupled with radiolabeled tracer is used to analyze specifically targeted biological event in the subject ( 42 ).…”
Section: Introductionmentioning
confidence: 99%
“…They could suppress postnatal neurogenesis, trigger widespread apoptotic cell death in developing brain and eventually result in long-term neurobehavioral impairment. [26,27] The mechanism of cell death triggered by anaesthetic drugs involves translocation of Bax protein to mitochondrial membranes, where it disrupts membrane permeability, allowing extra-mitochondrial leakage of cytochrome c, followed by a sequence of changes culminating in activation of caspase-3 [ Figure 2]. The specific steps in the upstream pathways through which the signal is relayed from the cell surface GABA A receptors to Bax protein remain to be identified.…”
Section: Role Of N-methyl D-aspartate Receptors and Gamma-amino Butyrmentioning
confidence: 99%