Application of microwave irradiation in the synthesis of P-heterocycles

Efficient microwave-assisted selective alkaline hydrolysis of diversely substituted phosphonate esters

“…MAOS is based on the efficient heat transfer achieved by dielectric heating, which, in turn, is mainly dependent on the ability of the solvent or reagents to absorb microwave energy. In addition, it has been demonstrated that microwave heating seems to be perfectly suited for phosphorus chemistry, 24 since such species are expected to absorb microwave energy efficiently via a conduction mechanism. 25 Taking all these observations into account, we report herein a novel, rapid, and efficient microwave-assisted protocol for the selective alkaline hydrolysis of dialkyl phosphonates that resulted in the formation of diversely substituted phosphonic acid monoesters, that are otherwise difficult to obtain by conventional approaches.…”