Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease

Dragomiretska, N. V.; Babov, Konstantin D; Gushcha, Sergеy; Заболотна, І. Б.; Plakida, Alexander; Izha, Аnna; Babova, Irina K; Насибуллін, Б. А.; Trubka, I.A.

doi:10.23736/s1121-421x.20.02601-x

Cited by 10 publications

(10 citation statements)

References 26 publications

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“…Studies have shown the benefits of alkaline water in gastroesophageal reflux (21,22), certain cancers (23,24), and in reducing the blood viscosity (25). Athletes supplemented with alkaline water after high-intensity interval exercises were found to experience favorable changes in hydration status with lower urine specific gravity, higher urine pH, and more efficient use of lactates (20,26).…”

Section: Discussionmentioning

confidence: 99%

Baseline urine pH is related to effective urine alkalization by short-term alkaline water supplementation: data from a self-controlled study in healthy Chinese volunteers following a systematic review and meta-analysis of literature

Zhang¹,

Deng²,

Deng³

et al. 2022

Transl Androl Urol

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Background: The outcomes of urine alkalization with alkaline water supplementation vary greatly across studies and therefore remain inconclusive, probably arising from differences in study design, ethnic group, and source of alkaline water, which needs further clarification. With a systematic review of literature, followed by an empirical observation among healthy Chinese volunteers, we aimed to investigate the outcomes of urine alkalization with alkaline water vs. daily drinking water, and whether these outcomes are intersected by certain factors such as gender and body mass index (BMI).Methods: We conducted a literature search of related studies on alkaline water supplementation and urine pH using the PubMed, Embase, Medline and Cochrane Library databases. The publication bias was assessed with inverted funnel plotting. Chi-square-based Q-test and I 2 -statistic test were used to examine the data heterogeneity. The studies were evaluated for quality using the Cochrane risk of bias tool or Newcastle-Ottawa Scale (NOS). The meta-analysis was followed by a study in healthy volunteers. As per protocol, all subjects remained on regular drinking water for one week and were switched to alkaline water for the next week. Urine pH was measured thrice daily and averaged. The mean urine pH values in the first and second weeks were compared for all subjects. Alkalization gains in urine pH (AGU-pH) was computed to determine the outcome of alkaline water supplementation in relation to baseline urine pH.Results: Our systematic review of literature yielded limited data about the effect of alkaline water on urine pH. Despite an increase in urine pH after supplementation of alkaline water as indicated by the randomeffect model, a high heterogeneity across the included studies (I 2 =94%, P<0.001) precluded a robust determination. In our volunteer study, alkaline water led to elevation of urine pH from baseline in 84.9% of all subjects or by BMI stratification. Effective urine alkalization was noted in males but not in females.Subjects who presented effective urine alkalization had significantly lower baseline urine pH compared with those who did not (5.94±0.27 vs. 6.22±0.22, P=0.0016). The negative correlation between AGU-pH and baseline urine pH (r=−0.236, P=0.044) and receiver operating curve (ROC) analysis suggested that subjects with more "acidic" urine, particularly those with a baseline urine pH ≤6.0 (maximum Youden index =1.548, cut-off =5.977), could show more pronounced outcome of urine alkalization from oral alkaline water.Conclusions: Our meta-analysis and human subjects study revealed that alkaline water supplementation may be useful for urine alkalization, particularly in individuals with a lower urine pH. The outcomes seem not significantly pronounced in females, although more efforts warranted for validation. Short-term use of alkaline water is well-tolerated and not associated with over-alkalization of the urine.

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Section: Discussionmentioning

confidence: 99%

Baseline urine pH is related to effective urine alkalization by short-term alkaline water supplementation: data from a self-controlled study in healthy Chinese volunteers following a systematic review and meta-analysis of literature

Zhang¹,

Deng²,

Deng³

et al. 2022

Transl Androl Urol

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“…In 2020, Dragomiretska et al published a study in which 90 patients from Ukraine were divided into three equal arms according to the main treatment: i) pharmacologically with proton pump inhibitor, ii) bicarbonate mineral water, and iii) magnesium sulfur bicarbonate mineral water. The results indicated the highest efficacy on dyspepsia and pain syndrome of treatment applied in the third group (32).…”

Section: Evidence-based Literature Data Focused On the Benefit Of Crenotherapy For Gi (Gastrointestinal) Tract Pathologiesmentioning

confidence: 92%

“…Other literature data referring to the effects of magnesium-sulfur mineral waters on functional constipation concluded that mineral waters such as Hepar (France), Ensinger Schiller Quelle-ESQ (Germany), and Donat Mg (Slovenia) represent a natural option for treatment in functional constipation, having a laxative effect, without noticeable side effects (9,32). The authors recommend the daily magnesium consumption of at least 20 mM for a minimum of one week to obtain the mentioned effects (32).…”

Section: Evidence-based Literature Data Focused On the Benefit Of Crenotherapy For Gi (Gastrointestinal) Tract Pathologiesmentioning

confidence: 99%

Benefits of crenotherapy in digestive tract pathology (Review)

Dumitrescu

Iliescu²,

Mazilu³

et al. 2021

Exp Ther Med

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Balneotherapy, a branch of physical and rehabilitation medicine using the natural factors of balneal resorts for therapeutical purposes to modulate the symptoms of numerous diseases, represents a non-pharmaceutical therapeutic alternative, easily accepted by patients and used both preventively and curatively. Crenotherapy, a branch of balneotherapy, is the method in which mineral waters are used as a therapeutic internal cure by ingestion. This procedure is performed in spa resorts (where these natural resources exist), and the ingestion of mineral water takes place at the source (spring), in the quantities recommended by the medical rehabilitation physician, according to specific regimens for the condition to be treated. Depending on their physical and chemical composition, the therapeutic mineral waters fall into several categories, having clear indications for certain pathologies. Hypotonic, isotonic, or slightly hypertonic mineral waters are recommended in diseases of the digestive tract and hepatobiliary conditions. Over time, studies have been conducted to determine the effect of these types of treatments, highlighting the complex influence of crenotherapy on the gastrointestinal tract, with favorable results, therefore the use of mineral water intake in various pathologies being recommended. The current review focuses on the existing literature data and refers to the main progress made in understanding the benefit, indications, and crenotherapy procedures in the management of gastrointestinal disorders. Contents1. Introduction 2. Pathogenic background for crenotherapy usage 3. Evidence-based literature data focused on the benefit of crenotherapy for GI (gastrointestinal) tract pathologies 4. Conclusions

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“…Mineral waters (MW) are one of the natural healing factors used to prevent and treat many nosologies [1,2,3,4]. According to modern concepts, MW are nonspecific modulators [5,6,7,8], that is, factors that maintain or restore the coordination and balance of the body's functional systems.…”

Section: Introductionmentioning

confidence: 99%

Features of the reaction of the kidney function of healthy rats to the intake of boric hydrocarbonate sodium mineral waters of varying quantitative macro- and micro-composition

Насибуллін

Аrabadji

et al. 2022

J Educ Health Sport

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The purpose of the work is a comparative assessment of the effect of boron hydrocarbonate sodium mineral waters with a varying quantitative and qualitative composition of macroelements and with different amounts of a bioactive element on the state of the urinary system of rats. Materials and methods. The work was performed on 81 white rats of the Wistar line of auto bred breeding, weighing 180-200 g. The rats were divided into four groups: group 1 - 21 intact rats served as controls; group 2 - 20 rats treated intragastrically with a soft probe MW "Polyana Ploskivskaya" at a dose of 1% of body weight daily, a course of 7 days; group 3 - 20 rats treated with MW "Polyana Kupel" according to the above method; group 4 - 20 rats treated with MW "Svalyava" according to the above process. Before removing the animals from the experiment, daily urine was collected from them; blood was also taken from the tail vein for biochemical studies. At autopsy, pieces of kidneys were taken for histological and histoenzymological studies (the activity of succinate dehydrogenase and lactate dehydrogenase was determined). Results. The histological studies showed no pathological changes in the kidneys were observed with the use of the studied boron MW. Still, there were structural changes, as well as an increase in the activity of redox enzymes. Changes in kidney function were unidirectional with using any of the investigated MW. Still, they had quantitative differences, which are less related to the amount of boron (in the form of orthoboric acid) in 1 liter of MW and more dependent on the osmolarity of the MW, the qualitative composition of macronutrients, and their ratio. Conclusion. We believe that osmolarity, as an integrated indicator of the state of the macronutrient component of MW, can be used to assess its effect on the structural and functional characteristics of the kidneys.

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Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease

Cited by 10 publications

References 26 publications

Baseline urine pH is related to effective urine alkalization by short-term alkaline water supplementation: data from a self-controlled study in healthy Chinese volunteers following a systematic review and meta-analysis of literature

Baseline urine pH is related to effective urine alkalization by short-term alkaline water supplementation: data from a self-controlled study in healthy Chinese volunteers following a systematic review and meta-analysis of literature

Benefits of crenotherapy in digestive tract pathology (Review)

Features of the reaction of the kidney function of healthy rats to the intake of boric hydrocarbonate sodium mineral waters of varying quantitative macro- and micro-composition

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