Application of Mixed Electron‐Impact‐Chemical Ionization High‐Resolution Mass Spectrometry to a Medicinal Agent

Characteristics of in-beam electron impact ionization mass spectra of several amino sugars, which give barely detectable molecular ion peaks by the use of conventional direct inlet probes, are described. The spectra of these compounds almost always exhibited the M + l peak and the spectral features were apparently a combination of those of the conventional electron impact spectrum and some major peaks originating from the M + l ions. In the case of neamine, effects of the measurement conditions such as the source temperature, ionizing voltage, the position of the sample and time factors on the intensity of the M + 1 peak were examined. When the samples were mixed with ammonium chloride, the M + l peaks in the in-beam spectra were completely suppressed, while with aqueous ammonia, the abundance of the M + 1 peaks increased by several times.

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In-beam electron impact mass spectrometry of amino sugars

Ohashi

Yamada

Kudo

et al. 1978

Biol. Mass Spectrom.

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In‐beam electron impact mass spectrometry of aliphatic alcohols

Ohashi

Nakayama

1978

Org. Mass Spectrom.

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The characteristics of the in-beam electron impact mass spectra of six isomers of undecanol as well as several 1-alkanols have been examined. In addition to the characteristic ions observed in the conventional electron impact spectra, the [ZM+ 1]+, [:!M+l-H,O]+, [ZM+ 1-2HzO]', [ZM-R or R]+, [ZM-H,O-R or R']+, [2M -2H20 -R or R ' ] ' and [M + 1 -&O]' peaks are common in the in-beam electron impact mass spectra of the undecanol isomers of structure RCH(0H)R'. Deuterium labelling experiments have shown that the extra proton in the protonated dimer ions, [ZM + 1]+, originates from the hydroxy group. The processes which produce the important peaks in ithe high mle regions are discussed.

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Low‐resolution accurate mass measurement in self‐chemical ionization mass spectrometry

Caldwell

Masucci

Inners

1988

Org. Mass Spectrom.

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Low-resolution (2000, 10% valley definition) accurate mass measurements using self-chemical ionization (self-CI) have been evaluated as an alternative to the conventional chemical ionization (CI) method. In conventional CI experiments a high pressure of reagent gas is required to induce ionization while in self-CI no reagent gas is used and the self-CI is produced presumably by molecular/fragment iowmolecule reactions. Nine compounds ranging in mass from 50-500 daltons were examined. Results obtained by the self-CI method indicate that the elemental composition assignment can be obtained simultaneously for the protonated molecule and/or molecular ion. It is also shown that perfluorokerosene can be used routinely in self-CI as an internal reference standard over a broad mass range (50-500 daltons). It is sometimes difficult to use a single reference standard in conventional low-resolution CI accurate mass spectrometry over a similar mass range. I N T R O D U C T I O N

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Application of Mixed Electron‐Impact‐Chemical Ionization High‐Resolution Mass Spectrometry to a Medicinal Agent

Cited by 10 publications

References 8 publications

In-beam electron impact mass spectrometry of amino sugars

In-beam electron impact mass spectrometry of amino sugars

In‐beam electron impact mass spectrometry of aliphatic alcohols

Low‐resolution accurate mass measurement in self‐chemical ionization mass spectrometry

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