Application of modern antiadhesive agents in surgery

Meshkova, O. A.; Bogdanov, D. Yu.; Матвеев, Н. Л.; Курганов, И. А.

doi:10.17116/endoskop201521337-42

Cited by 5 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Creating an animal model of abdominal adhesions with consistent, reliable and reproducible results for positive control is a major challenge. Currently, researches are ongoing to find more efficient anti-adhesion agents and components [7,13,15]. In this experimental study, anti-adhesion agents, such as mezogel, metronidazole, dextran, and contrykal, were used.…”

Section: Resultsmentioning

confidence: 99%

Types and Localization of Abdominal Adhesions after Open Operations (Experimental Study)

Akhmedov¹

2022

View full text Add to dashboard Cite

There is a great need for more efficient and more widely used preventive treatment of post-operative abdominal adhesions. Objective - to study the type of adhesions in the abdominal cavity after open operations in the experiment. Materials and methods. The study was conducted on 90 white outbred rats divided into three groups. We mechanically damaged the surface of the small bowel segment in all rats. The control group (group 1) included 30 rats not administered any drugs into the abdominal cavity after the small bowel segment damage. The comparison group (group 2) consisted of 30 rats, which were introduced one mL of mezogel. The study group comprised 30 rats, which were administered a 1 mL mixture of metronidazole, dextran, contrykal (in a ratio of 1:1:0.1, respectively) + O2 into the abdominal cavity; the wound of the latter was closed using a layered suture technique. On days 5, 10 and 21, the tissues taken from the suture site, peritoneum, damaged small bowel segment, liver, and omentum were analysed histologically. Results. On day 10 in groups 1 and 2, compared to day 5, the proportion of filmy adhesions decreased by 45.9% (p=0.004), but the proportion of dense adhesions increased by 64.7%. The comparative between-group analysis on day 5 in groups 1 and 2 revealed no difference in the proportion of filmy adhesions, whereas in group 3 the proportion of filmy adhesions was 4% higher and the proportion of dense adhesions was 16.5% lower. Planar adhesions predominated in all groups. Conclusions. There were more filmy adhesions seen on day 1, and the complete dense adhesion formation was observed by day 21. Planar adhesions predominated (54.5  60.0%). The area of postoperative sutures was involved in the adhesion formation. The adhesions in the sutures - peritoneum area as well as the omental adhesions were detected in all animals. Introduction of drugs, mezogel or a mixture of metronidazole, dextran, contrykal + O2, into the abdominal cavity contributed to the reduction of adhesions between the small bowel loops. The experiments with laboratory animals were provided in accordance with all bioethical norms and guidelines. No conflict of interests was declared by the author.

show abstract

Section: Resultsmentioning

confidence: 99%

Types and Localization of Abdominal Adhesions after Open Operations (Experimental Study)

Akhmedov¹

2022

View full text Add to dashboard Cite

show abstract

“…По данным экспертов Международного общества изучения спаек (International Adhesion Society, Dallas, TX, USA), адгезивный процесс является наиболее частым осложнением хирургических операций на органах брюшной полости [1][2][3] и малого таза [4][5][6][7]. Количество рецидивов в раннем и позднем послеоперационном периоде после вмешательств по поводу спаечной болезни достигает 32-71% [8], при этом лапароскопическая хирургия, в сравнении с открытыми операциями, практически не снижает частоту и распространенность спаечного процесса [9].…”

Section: Introductionunclassified

Anti-adhesive membranes based on crosslinked carboxymethyl cellulose

Zhukovskiy

Nemilov

Filipenko

et al. 2021

Vestn. Voronež. gos. univ. inž. tehnol.

View full text Add to dashboard Cite

In recent times, new anti-adhesion devices including devices based on carboxymethyl cellulose (CMC), which have “barrier” effect are being developed and actively introduced into surgical practice. The “barrier” should be completely resorbed after the time required to healing the morphofunctional integrity of the injured peritoneum, be economically available and easy to use (including laparoscopic technologies). But the time when the CMC is in the body is insufficient to prevent the formation of adhesions, particularly in the presence of non-absorbable rigid implants. The reactive functional groups in CMC allow to transform the CMC-macromolecule into a spatial structure. For this are required the using of bifunctional (bicarboxylic or aminocarboxylic) acids and the transform of a part of the carboxyl groups from the Na-form to the hardly soluble H-form, i.e., it is necessary to crosslink CMC-macromolecules. Adipic acid and glutaric acid, aminoacetic acid and amino capronic acid used are linking agents. The influence of modification parameters on the degree of polymers swelling in water is studied. As a result, to obtain membranes designed for the treatment of adhesive disease, it is recommended to use additives in CMC of bifunctional compounds.

show abstract