Climate change is demonstrated through global surface temperatures increase in the last century. To stop this phenomenon, new regulations that ban or taxes greenhouse gas fluids (HFC among them) have being approved. In the medium term, only low-GWP refrigerants will be permitted in developed countries. HFO are synthetic fluids that show similar properties to used HFC. Among them, one of the most promising is R1234ze(E). This refrigerant presents good environmental properties and can be used in most of HVACR applications, pure or mixed with HFC or natural refrigerants (mainly CO2). This paper collects the most relevant research about R1234ze(E) thermophysical and compatibility properties, heat transfer and pressure drop characteristics, and vapour compression system performance; separating those works that considers R1234ze(E) pure or blended. Once analyzed literature available, it can be concluded that pure R1234ze(E) is a good option only in new HVACR systems. Nevertheless, if it is combined with other refrigerants also reduces considerably the final GWP value, maintaining efficiency parameters at levels that allow them to replace R134a, R404A or R410A in existing systems with minor modifications.