Application of MOF materials as drug delivery systems for cancer therapy and dermal treatment

Mallakpour, Shadpour; Nikkhoo, Elham; Hussain, Chaudhery Mustansar

doi:10.1016/j.ccr.2021.214262

Cited by 396 publications

(177 citation statements)

References 129 publications

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“…Metal-organic frameworks (MOFs), or coordination polymers, are a novel type of highly porous materials with a crystalline structure [1]. The flexible network, tunable pore sizes, and rich physicochemical properties enable them to be promising materials for gas separation, capture and storage, catalysis, chemical sensors, and biomedicine [2][3][4][5]. MOFs have ultrahigh porosity (up to 90% free volume), an enormous internal surface area, and surface area (beyond 6000 m 2 /g 3 ), supporting their applications in molecules' adsorption, drug loading, and release [4,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…The flexible network, tunable pore sizes, and rich physicochemical properties enable them to be promising materials for gas separation, capture and storage, catalysis, chemical sensors, and biomedicine [2][3][4][5]. MOFs have ultrahigh porosity (up to 90% free volume), an enormous internal surface area, and surface area (beyond 6000 m 2 /g 3 ), supporting their applications in molecules' adsorption, drug loading, and release [4,6,7]. The incorporation of MOFs into a polymer as mixed-matrix membranes provides a solution to manipulate and process the crystalline and robust MOFs [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Iodine Immobilized UiO-66-NH2 Metal-Organic Framework as an Effective Antibacterial Additive for Poly(ε-caprolactone)

et al. 2022

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Iodine has been widely used as an effective disinfectant with broad-spectrum antimicrobial potency. However, the application of iodine in an antibacterial polymer remains challenging due to its volatile nature and poor solubility. Herein, iodine immobilized UiO-66-NH2 metal-organic framework (MOF) (UiO66@I2) with a high loading capacity was synthesized and used as an effective antibacterial additive for poly(ε-caprolactone) (PCL). An orthogonal design approach was used to achieve the optimal experiments’ conditions in iodine adsorption. UiO66@I2 nanoparticles were added to the PCL matrix under ultrasonic vibration and evaporated the solvent to get a polymer membrane. The composites were characterized by SEM, XRD, FTIR, and static contact angle analysis. UiO-66-NH2 nanoparticles have a high iodine loading capacity, up to 18 wt.%. The concentration of iodine is the most important factor in iodine adsorption. Adding 0.5 wt.% or 1.0 wt.% (equivalent iodine content) of UiO66@I2 to the PCL matrix had no influence on the structure of PCL but reduces the static water angle. The PCL composites showed strong antibacterial activities against Staphylococcus aureus and Escherichia coli. In contrast, the same content of free iodine/PCL composites had no antibacterial activity. The difference in the antibacterial performance was due to the different iodine contents in the polymer composites. It was found that MOF nanoparticles could retain most of the iodine during the sample preparation and storage, while there was few iodine left in the free iodine/PCL composites. This study offers a common and simple way to immobilize iodine and prepare antibacterial polymers with low antiseptic content that would reduce the influence of an additive on polymers’ physical properties.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Iodine Immobilized UiO-66-NH2 Metal-Organic Framework as an Effective Antibacterial Additive for Poly(ε-caprolactone)

et al. 2022

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“…Metal oxides nanoparticles (NPs) have been widely exploited for many different areas such as toxic pollutants removal ( Gowthaman et al, 2020 ; Yang et al, 2020 ; Zhou et al, 2021 ), drug delivery ( He et al, 2019 ; Mallakpour et al, 2022 ), hydrogen production ( Chen et al, 2015 ; Bhosale et al, 2016 ; Chen et al, 2018 ), CO 2 reduction ( Loh and Kherani, 2019 ; Sun et al, 2021 ; Kuan et al, 2022 ), optoelectronics ( C. Nehru et al, 2012 ; Jayakumar et al, 2022 ; Wang et al, 2010 ), etc., Controllable growth of metal oxides NPs with defined morphology such as spherical, rod-like, sheet-like, cubic amongst others have been synthesized and reported to have an influence on their catalytic properties.…”

Section: Anion Directed Synthesis Of Metal Oxidesmentioning

confidence: 99%

Role of Anions in the Synthesis and Crystal Growth of Selected Semiconductors

2022

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The ideal methods for the preparation of semiconductors should be reproducible and possess the ability to control the morphology of the particles with monodispersity yields. Apart from that, it is also crucial to synthesize a large quantity of desired materials with good control of size, shape, morphology, crystallinity, composition, and surface chemistry at a reasonably low production cost. Metal oxides and chalcogenides with various morphologies and crystal structures have been obtained using different anion metal precursors (and/or different sulfur sources for chalcogenides in particular) through typical synthesis methods. Generally, spherical particles are obtained as it is thermodynamically favorable. However, by changing the anion precursor salts, the morphology of a semiconductor is influenced. Therefore, precursors having different anions show some effects on the final forms of a semiconductor. This review compiled and discussed the effects of anions (NO3−, Cl−, SO42-, CH3COO−, CH(CH3)O−, etc.) and different sources of S2- on the morphology and crystal structure of selected metal oxides and chalcogenides respectively.

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“…These MOFs also have potential applications in the research areas of Pharmacy and Medicine, highlighting those related to advanced drug delivery [133][134][135][136][137]. The use of photoresponsive MOFs to encapsulate drugs would permit the release at a specific time or a target place by applying a light input.…”

Section: General Remarksmentioning

confidence: 99%

Photoresponsive Metal-Organic Frameworks as Adjustable Scaffolds in Reticular Chemistry

Saura‐Sanmartin

2022

IJMS

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The easy and remote switching of light makes this stimulus an ideal candidate for a large number of applications, among which the preparation of photoresponsive materials stands out. The interest of several scientists in this area in order to achieve improved functionalities has increase parallel to the growth of the structural complexity of these materials. Thus, metal-organic frameworks (MOFs) turned out to be ideal scaffolds for light-responsive ligands. This review is focused on the integration of photoresponsive organic ligands inside MOF crystalline arrays to prepare enhanced functional materials. Besides the summary of the preparation, properties and applications of these materials, an overview of the future outlook of this research area is provided.

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Application of MOF materials as drug delivery systems for cancer therapy and dermal treatment

Cited by 396 publications

References 129 publications

Iodine Immobilized UiO-66-NH2 Metal-Organic Framework as an Effective Antibacterial Additive for Poly(ε-caprolactone)

Iodine Immobilized UiO-66-NH2 Metal-Organic Framework as an Effective Antibacterial Additive for Poly(ε-caprolactone)

Role of Anions in the Synthesis and Crystal Growth of Selected Semiconductors

Photoresponsive Metal-Organic Frameworks as Adjustable Scaffolds in Reticular Chemistry

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