Application of molecularly imprinted hydrogel for the preparation of lactose‐free milk

Hadizadeh, Farzin; Moghadam, Maryam Hassanpour; Mohajeri, Seyed Ahmad

doi:10.1002/jsfa.5757

Cited by 22 publications

(10 citation statements)

References 42 publications

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“…This figure indicates the efficacy of MISPME method in sample preconcentration and preparation before HPLC analysis of tramadol, whereas NIP, as the sorbent in SPME, could not extract the tramadol with the same washing and eluting protocol as applied for MIP. Like previous studies, the performance of the imprinted polymers in MISPE procedure in extraction and analysis in aqueous media was very promising (Hadizadeh et al, ; Mohajeri & Ebrahimi, ; Mohajeri et al ., ; Sahebnasagh et al ., ; Rahmani et al ., ).…”

Section: Resultssupporting

confidence: 56%

“…Thus, an optimum condition should be applied to minimize nonspecific bindings in MIP (Alizadeh, Zare, Ganjali, Norouzi, & Tavana, ). MAA was selected as a functional monomer according to our previous studies (Hadizadeh, Hassanpour Moghadam, & Mohajeri, ; Hadizadeh, Zakerian, & Mohajeri, ; Mohajeri & Ebrahimi, ; Mohajeri, Karimi, & Khansari, ; Mohajeri, Malaekeh‐Nikouei, & Sadegh, ; Sahebnasagh, Karimi, & Mohajeri, ). Owing to the presence of functional groups such as amine (−NH 2 ) and hydroxyl (−OH) groups in the chemical structure of tramadol and carboxylic acid (−COOH) group in MAA, strong electrostatic and ionic interactions could be formed in organic and aqueous media (Figure ).…”

Section: Resultsmentioning

confidence: 99%

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Development of solid‐phase microextraction coupled with liquid chromatography for analysis of tramadol in brain tissue using its molecularly imprinted polymer

Monireh

Mohammadpour

Mohajeri

2016

Biomedical Chromatography

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In this work, performance of a molecularly imprinted polymer (MIP) as a selective solid-phase microextraction sorbent for the extraction and enrichment of tramadol in aqueous solution and rabbit brain tissue, is described. Binding properties of MIPs were studied in comparison with their nonimprinted polymer (NIP). Ten milligrams of the optimized MIP was then evaluated as a sorbent, for preconcentration, in molecularly imprinted solid-phase microextraction (MISPME) of tramadol from aqueous solution and rabbit brain tissue. The analytical method was calibrated in the range of 0.004 ppm (4 ng mL ) and 10 ppm (10 μg mL ) in aqueous media and in the ranges of 0.01 and 10 ppm in rabbit brain tissue, respectively. The results indicated significantly higher binding affinity of MIPs to tramadol, in comparison with NIP. The MISPME procedure was developed and optimized with a recovery of 81.12-107.54% in aqueous solution and 76.16-91.20% in rabbit brain tissue. The inter- and intra-day variation values were <8.24 and 5.06%, respectively. Finally the calibrated method was applied for determination of tramadol in real rabbit brain tissue samples after administration of a lethal dose. Our data demonstrated the potential of MISPME for rapid, sensitive and cost-effective sample analysis.

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Section: Resultssupporting

confidence: 56%

Section: Resultsmentioning

confidence: 99%

Development of solid‐phase microextraction coupled with liquid chromatography for analysis of tramadol in brain tissue using its molecularly imprinted polymer

Monireh

Mohammadpour

Mohajeri

2016

Biomedical Chromatography

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“…Lactose is the main carbohydrate in milk, with a concentration of 4-5 percent in bovine milk (Hadizadeh, Moghadam, and Mohajeri 2013). Lactose-reduced products (lactose content less than 1.2 percent) are important for individuals (75 percent of adults worldwide) who suffer from lactose intolerance, a condition characterized by excessive intestinal gas, nausea, cramps, and diarrhea (Sharma, Sehgal, and Kumar 2002;Wilt et al 2010;Mummah et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Determination of Lactose in Milk by Raman Spectroscopy

Chen

et al. 2015

Analytical Letters

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A Raman spectroscopy-based approach was developed for the rapid determination of lactose in milk using crystal violet as an internal standard. The crystal violet peak at 1173 reciprocal centimeters did not interfere with the lactose peak at 1085 reciprocal centimeters; therefore, crystal violet can be used to quantify lactose in milk. This developed method allowed the determination of lactose from 0.028-0.1 mole per liter, with a limit of detection of 0.019 mole per liter. The results revealed that Raman spectroscopy is a simple and rapid method for the determination of lactose in milk.

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“…To date, MIPs have often been applied to extract and separate the active ingredients from traditional Chinese herbs. 8,168 That mainly involves the qualitative separation of some compounds with simple structures, such as alkaloids, [169][170][171] flavones, 100,172,173 esculine, 174 glycyrrhizin, 175 rographolide, 176 and polyhydric phenols. 177 Good results were obtained thanks to the selective recognition of specific analytes or a group of structural analogs.…”

Section: Review Wileyonlinelibrarycom/appmentioning

confidence: 99%

Recent advances in molecularly imprinted polymers in food analysis

Song

Chen

et al. 2014

J of Applied Polymer Sci

106

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Food security as a world issue has received increasing concern, and therefore, effective analytical methods and technologies have been continuously developed. However, the matrix complexity of food samples and the trace/ultratrace presence of targeted analytes require highly efficient cleanup and enrichment materials and procedures. Molecularly imprinted polymers (MIPs) with specific recognition abilities as versatile materials are being increasingly developed for diverse species in various fields, especially in food analysis. In this review, we mainly summarize the recent advances in MIPs used for food matrices over the last 5 years. We focus on toxic and harmful substances, such as pesticide/drug residues, heavy metals, microbial toxins, and additives. Some relatively new preparation methods involving surface imprinting, composites, and stimuli responsiveness are reviewed. Different MIPs as solid-phase adsorbents in solid-phase extraction, solid-phase microextraction, matrix solid-phase dispersion, stirring bar sorptive extraction, and magnetic material extraction and as stationary phases in chromatographic separation for foodstuff have been comprehensively summarized. MIP-based biomimetic sensing and enzymelike catalysis receive special attention. Moreover, some limitations and comparisons related to MIPs performances are also discussed. Finally, some significant attempts to further promote MIP properties and applications to ensure food safety are discussed.

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Application of molecularly imprinted hydrogel for the preparation of lactose‐free milk

Abstract: The results indicated that MIP₂, as an optimised imprinted hydrogel, can effectively bind lactose and decrease its concentration in milk.

Cited by 22 publications

References 42 publications

Development of solid‐phase microextraction coupled with liquid chromatography for analysis of tramadol in brain tissue using its molecularly imprinted polymer

Development of solid‐phase microextraction coupled with liquid chromatography for analysis of tramadol in brain tissue using its molecularly imprinted polymer

Determination of Lactose in Milk by Raman Spectroscopy

Recent advances in molecularly imprinted polymers in food analysis

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