Application of Molecularly Imprinted Polymers for the Detection of Volatile and Off-Odor Compounds in Food Matrices

Cengiz, Nurten; Güçlü, Gamze; Kelebek, Haşim; Capanoglu, Esra; Selli, Serkan

doi:10.1021/acsomega.1c07288

Cited by 13 publications

(6 citation statements)

References 54 publications

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“…Gas sensor elements based on molecularly imprinted polymers (MIPs) have several advantages over alternative technologies in their durability and selectivity [ 1 , 2 , 3 , 4 ] and have previously demonstrated application in food analysis [ 5 , 6 , 7 , 8 ], explosives detection [ 9 , 10 , 11 ], medical diagnosis [ 12 , 13 , 14 ], and pollution monitoring [ 15 , 16 , 17 ]. Detection limits of MIP sensors may be in the ppt range [ 18 , 19 , 20 ], interferent binding can be negligible [ 21 , 22 , 23 ], and the range of possible target molecules is extremely broad.…”

Section: Introductionmentioning

confidence: 99%

“…There are several excellent reviews of the use MIPs in gas sensors, but they principally focus on a specific technology or technological application. Reviews of specific techniques, for example, include the use of MIPs in gravimetric sensors and solid phase microextraction [ 3 , 13 ], while reviews of applications include targeting of a specific molecule [ 9 , 17 ], or use in a specific industrial setting [ 6 , 15 ]. The specificity of these reviews require discrimination in the selection of relevant articles to discuss.…”

Section: Introductionmentioning

confidence: 99%

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Template Imprinting Versus Porogen Imprinting of Small Molecules: A Review of Molecularly Imprinted Polymers in Gas Sensing

Cowen

Cheffena

2022

IJMS

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The selective sensing of gaseous target molecules is a challenge to analytical chemistry. Selectivity may be achieved in liquids by several different methods, but many of these are not suitable for gas-phase analysis. In this review, we will focus on molecular imprinting and its application in selective binding of volatile organic compounds and atmospheric pollutants in the gas phase. The vast majority of indexed publications describing molecularly imprinted polymers for gas sensors and vapour monitors have been analysed and categorised. Specific attention was then given to sensitivity, selectivity, and the challenges of imprinting these small volatile compounds. A distinction was made between porogen (solvent) imprinting and template imprinting for the discussion of different synthetic techniques, and the suitability of each to different applications. We conclude that porogen imprinting, synthesis in an excess of template, has great potential in gas capture technology and possibly in tandem with more typical template imprinting, but that the latter generally remains preferable for selective and sensitive detection of gaseous molecules. More generally, it is concluded that gas-phase applications of MIPs are an established science, capable of great selectivity and parts-per-trillion sensitivity. Improvements in the fields are likely to emerge by deviating from standards developed for MIP in liquids, but original methodologies generating exceptional results are already present in the literature.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Template Imprinting Versus Porogen Imprinting of Small Molecules: A Review of Molecularly Imprinted Polymers in Gas Sensing

Cowen

Cheffena

2022

IJMS

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“…Developing the bioprobe is the key to producing more practical odor sensors. The range of the probes spans from synthetic molecules and polymers 28 to engineered proteins such as olfactory receptors. 9 The flat surface and high surface area of graphene are suitable for surface functionalization and characterization.…”

Section: Resultsmentioning

confidence: 99%

Enantioselective Detection of Gaseous Odorants with Peptide–Graphene Sensors Operating in Humid Environments

Yamazaki,

Hitomi,

Homma

et al. 2024

ACS Appl. Mater. Interfaces

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Replicating the sense of smell presents an ongoing challenge in the development of biomimetic devices. Olfactory receptors exhibit remarkable discriminatory abilities, including the enantioselective detection of individual odorant molecules. Graphene has emerged as a promising material for biomimetic electronic devices due to its unique electrical properties and exceptional sensitivity. However, the efficient detection of nonpolar odor molecules using transistor-based graphene sensors in a gas phase in environmental conditions remains challenging due to high sensitivity to water vapor. This limitation has impeded the practical development of gas-phase graphene odor sensors capable of selective detection, particularly in humid environments. In this study, we address this challenge by introducing peptide-functionalized graphene sensors that effectively mitigate undesired responses to changes in humidity. Additionally, we demonstrate the significant role of humidity in facilitating the selective detection of odorant molecules by the peptides. These peptides, designed to mimic a fruit fly olfactory receptor, spontaneously assemble into a monomolecular layer on graphene, enabling precise and specific odorant detection. The developed sensors exhibit notable enantioselectivity, achieving a remarkable 35-fold signal contrast between D-and L-limonene. Furthermore, these sensors display distinct responses to various other biogenic volatile organic compounds, demonstrating their versatility as robust tools for odor detection. By acting as both a bioprobe and an electrical signal amplifier, the peptide layer represents a novel and effective strategy to achieve selective odorant detection under normal atmospheric conditions using graphene sensors. This study offers valuable insights into the development of practical odor-sensing technologies with potential applications in diverse fields.

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“…Despite their high mechanical strength and robustness, MIPs may suffer from imprint leakage, which reduces their sensitivity [ 2 ]. MIPs have been used to detect small molecules [ 76 , 77 ]. Additionally, MIPs coupled with magnetic materials can achieve integrated separation and detection.…”

Section: Nanomaterials In Food Safety Analysismentioning

confidence: 99%

Nanomaterial-Based Fluorescent Biosensor for Food Safety Analysis

Zhou

Gui

et al. 2022

Biosensors

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Food safety issues have become a major threat to public health and have garnered considerable attention. Rapid and effective detection methods are crucial for ensuring food safety. Recently, nanostructured fluorescent materials have shown considerable potential for monitoring the quality and safety of food because of their fascinating optical characteristics at the nanoscale. In this review, we first introduce biomaterials and nanomaterials for food safety analysis. Subsequently, we perform a comprehensive analysis of food safety using fluorescent biosensors based on nanomaterials, including mycotoxins, heavy metals, antibiotics, pesticide residues, foodborne pathogens, and illegal additives. Finally, we provide new insights and discuss future approaches for the development of food safety detection, with the aim of improving fluorescence detection methods for the practical application of nanomaterials to ensure food safety and protect human health.

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Application of Molecularly Imprinted Polymers for the Detection of Volatile and Off-Odor Compounds in Food Matrices

Cited by 13 publications

References 54 publications

Template Imprinting Versus Porogen Imprinting of Small Molecules: A Review of Molecularly Imprinted Polymers in Gas Sensing

Template Imprinting Versus Porogen Imprinting of Small Molecules: A Review of Molecularly Imprinted Polymers in Gas Sensing

Enantioselective Detection of Gaseous Odorants with Peptide–Graphene Sensors Operating in Humid Environments

Nanomaterial-Based Fluorescent Biosensor for Food Safety Analysis

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