Application of multi-factorial experimental design to successfully model and optimize inorganic chromium speciation by square wave voltammetry

Cuéllar, Mariela; Pfaffen, Valeria; Ortiz, Patrícia I.

doi:10.1016/j.jelechem.2015.07.050

Cited by 21 publications

(10 citation statements)

References 39 publications

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“…One of the ways to optimize the number of experiments is the statistical design of the experiment (DOE). From numerous procedures of DOE [52,53], in this work, the central composite design (CCD) was selected and constructed for three factors. The calibration samples (training set) contained constituent patterns: the full factorial points (values − 1 or + 1 on each axis), central point and its repetitions (value 0 on each axis), and star points (at some value − γ or + γ on each axis).…”

Section: Design Of the Experiments Using Central Composite Designmentioning

confidence: 99%

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Multivariate approach in voltammetric identification and simultaneous determination of eugenol, carvacrol, and thymol on boron-doped diamond electrode

Kowalcze

Jakubowska

2019

Monatsh Chem

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The paper presents multivariate partial least-squares calibration model defined for the identification and simultaneous determination of phenolic terpenoids-eugenol, carvacrol, and thymol-by means of the differential pulse voltammetry. For the first time, using boron-doped diamond electrode signal, electrochemical distinction of carvacrol and thymol, despite the short distance between the peaks (15 mV), was described. The analytes' concentrations applied in the calibration model were selected using the 3-factorial central composite design. The multivariate partial least-squares model, with optimized data pre-processing, was used for determination of eugenol, carvacrol, and thymol in the concentration ranges of 0.77-13.86, 0.58-10.40, and 0.73-7.32 mg/dm 3 , respectively. The quality of the method, expressed by the root-mean-squared error of calibration was 0.55, 0.20, and 0.26 mg/dm 3 for the specified analytes. The recovery in the analysis of the pure signals was 98.92%, 101.62%, and 101.46%, what confirmed the possibility of clearly distinguishing the thymol and carvacrol peaks. In the spiked honey samples, the accuracy of eugenol, carvacrol, and thymol determination, expressed by the root-meansquared error of prediction, was in the range 0.20-0.83 mg/dm 3 , and recovery in the range 80.9-111.9%. Application of the presented model not only enables electrochemical identification and simultaneous determination of eugenol, carvacrol, and thymol, but also allows rapid, accurate, and low-cost verification of authenticity of the commercial products.

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Section: Design Of the Experiments Using Central Composite Designmentioning

confidence: 99%

“…Since the rotatability depends only on the value of γ, Eq. (1) is right [52,53]. The central point was repeated in six independent experiments, and the total number of samples considered in training set was 20.…”

Section: Design Of the Experiments Using Central Composite Designmentioning

confidence: 99%

Multivariate approach in voltammetric identification and simultaneous determination of eugenol, carvacrol, and thymol on boron-doped diamond electrode

Kowalcze

Jakubowska

2019

Monatsh Chem

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“…Namun, cara tersebut memiliki kelemahan utama yaitu tidak dapat mengamati interaksi antar parameter serta diperlukan jumlah percobaan yang banyak sehingga kurang efisien. Oleh karena itu, pada penelitian ini digunakan studi optimasi permukaan respon (respon surface methodology) Box-Behnken dengan jumlah percobaan lebih sedikit namun dapat mengamati interaksi antar parameter sehingga lebih efisien (Cuéllar and Ortiz, 2016;Quinlan and Lin, 2015;Yu and He, 2017).…”

Section: Pendahuluanunclassified

Penerapan Desain Eksperimen Plackett-Burman dan Box-Behnken pada Analisis Voltametri Pulsa Diferensial untuk Penentuan Kadar Senyawa Kompleks Gd-DTPA

et al. 2020

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Gadolinium merupakan salah satu golongan unsur tanah jarang yang menarik karena memiliki sifat paramagnetik yang tinggi. Pengkhelatan gadolinium dengan ligan dietilentriaminpentaasetat (DTPA) menghasilkan senyawa yang berguna dalam bidang kesehatan. Tujuan dari penelitian ini adalah menentukan kandungan unsur tanah jarang gadolinium sebagai kompleks dengan ligan DTPA secara voltametri pulsa diferensial dengan penerapan desain eksperimen Plackett-Burman dan Box-Behnken. Desain eksperimen Plackett-Burman digunakan untuk menyeleksi parameter yang memiliki relevansi positif terhadap respon arus. Parameter yang terpilih kemudian dioptimasi melalui desain eksperimen Box-Behnken sehingga diperoleh kondisi optimum tiap parameter. Parameter yang terseleksi meliputi konsentrasi ligan DTPA, waktu deposisi dan waktu kesetimbangan dengan nilai tiap parameter pada kondisi optimum masing-masing yaitu 150, 13 mgL-1, 60 detik dan 30 detik. Berdasarkan hasil pengukuran pada kondisi optimum didapat nilai presisi dan akurasi untuk kompleks Gd-DTPA yaitu 99,79% dan 93,42% dengan nilai limit deteksi dan kuantisasi untuk kompleks Gd-DTPA yaitu 3,97 mg/L dan 10,71 mg/L. The Application of Experimental Designs of Plackett-Burman and Box-Behnken in Differential Pulse Voltammetry Analysis for Gd-DTPA Complex Detection. Gadolinium is one of rare earth elements that is interesting because it has high paramagnetic properties. The gadolinium chelating with diethylentriaminpentaacetic acid (DTPA) ligands produces useful compounds in the health field. The purpose of this experiment is to determine amount of gadolinium as complex with DTPA on differential pulse voltammetry by applying Plackett-Burman and Box-Behnken experimental design. The method employed experimental design of Plackett-Burman to select factors, which have positive relevance to response. The selected factors are optimized based on experimental design of Box-Behnken to obtain the optimum condition each factors. The selected factors are ligand concentration, deposition time and equilibrium time with optimum value of 150 mgL-1, 60 s and 30 s, respectively. Based on the result of measurement at optimum condition, the precision and accuracy value for Gd-DTPA complex is 99.79% and 93.42% with detection and quantization limit value for Gd-DTPA complex is 3.97 mg/L and 10.71 mg/L.

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“…With use of adequate experimental design, a regression equation can be obtained where the importance of each independent variable in the global process can be obtained; furthermore, the possibility of considering interaction effects between the variables can be detected, being an advantage over the classical method . In the literature there are some reports describing multivariate optimization of the voltammetric response. − However, none of these before-mentioned articles describe NP determination.…”

Section: Introductionmentioning

confidence: 99%

“…In general, SWV optimization has been performed by a one-factor-at-a-time (OFAT) approach. ,,, However, we believe that all the analytical processes must be optimized by taking into account all the factors at once. We have already performed SWV parameters optimization for other compounds, ,, and we will continue optimizing analytical techniques by using design experiments methods.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Quantification of 4-Nitrophenol Using a Multivariate Optimized Plated Bismuth Film Electrode

Núñez

Betancourth

Ortiz

et al. 2019

Ind. Eng. Chem. Res.

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In this study the multivariate optimization of bismuth film deposition (BiFE) on glassy carbon electrode, together with square wave voltammetry parameters for nitrophenol quantification, is described for the first time. For this purpose, response surface methodology and desirability function were applied to a Box−Behnken design. For the BiFE deposition procedure, the relationship between the reduction current peak (i p ) and standard deviation values with time, potential deposition, and Bi(III) concentration were analyzed; meanwhile, for frequency, step, and amplitude only the relationship with i p was considered. The pH influence in nitrophenol determination was carried on by univariate analysis. After parameters optimization a limit of detection of 3.4 × 10 −6 mol L −1 was observed.

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Application of multi-factorial experimental design to successfully model and optimize inorganic chromium speciation by square wave voltammetry

Cited by 21 publications

References 39 publications

Multivariate approach in voltammetric identification and simultaneous determination of eugenol, carvacrol, and thymol on boron-doped diamond electrode

Multivariate approach in voltammetric identification and simultaneous determination of eugenol, carvacrol, and thymol on boron-doped diamond electrode

Penerapan Desain Eksperimen Plackett-Burman dan Box-Behnken pada Analisis Voltametri Pulsa Diferensial untuk Penentuan Kadar Senyawa Kompleks Gd-DTPA

Voltammetric Quantification of 4-Nitrophenol Using a Multivariate Optimized Plated Bismuth Film Electrode

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