Application of multipolymers system in the development of hydrogel-forming microneedle integrated with polyethylene glycol reservoir for transdermal delivery of albendazole

Mahfufah, Ulfah; Sultan, Nurul Aisha Fitri; Fitri, Andi Maqhfirah Nurul; Elim, Diany; Mahfud, Muhammad Alif Sya'ban; Wafiah, Nurfadilla; Friandini, Rissa Ardita; Chabib, Lutfi; Aliyah,; Permana, Andi Dian

doi:10.1016/j.eurpolymj.2022.111762

Cited by 23 publications

(13 citation statements)

References 57 publications

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“…This outcome aligns with previous research findings. The cross-linked films exhibited a distinctively smooth surface with reduced porosity, corroborating the cross-linking process. , …”

Section: Resultssupporting

confidence: 58%

“…An acceleration voltage of 15 kV was used. This study was also performed using a PVA–PVP film as a comparison …”

Section: Methodsmentioning

confidence: 99%

“…The cross-linked films exhibited a distinctively smooth surface with reduced porosity, corroborating the cross-linking process. 35,75 3.8. Surface pH.…”

Section: Mechanical and Insertion Properties Of Hfmnmentioning

confidence: 99%

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Application of Biomaterials in the Development of Hydrogel-Forming Microneedles Integrated with a Cyclodextrin Drug Reservoir for Improved Pharmacokinetic Profiles of Telmisartan

Enggi,

Sulistiawati,

Himawan

et al. 2024

ACS Biomater. Sci. Eng.

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However, its oral application is limited by its poor water solubility. This study presents the successful utilization of biomaterial-based hydrogelforming microneedles integrated with a direct compressed tablet reservoir (HFMN-DCT) for the transdermal delivery of telmisartan in the treatment of hypertension. The combination of PVP, PVA, and tartaric acid was used in the HFMN formulation. A range of cross-linking temperatures and times were employed to optimize the characteristics of the HFMN. The HFMN exhibited excellent swelling capacity, mechanical strength, and insertion properties. Additionally, the poorly soluble characteristic of TEL was improved by the inclusion complex formulation with β-cyclodextrin (βCD). Phase solubility analysis showed an A p -type diagram, indicating a higher-order complex between TEL and βCD, with respect to βCD. A ratio of TEL:βCD of 1:4 mM demonstrates the highest solubility enhancement of TEL. The inclusion complex formation was confirmed by FTIR, XRD, DSC, and molecular docking studies. A significantly higher release of TEL (up to 20-fold) from the inclusion complex was observed in the in vitro release study. Subsequently, a DCT reservoir was developed using various concentrations of sodium starch glycolate. Essentially, both the HFMN and DCT reservoir exhibit hemocompatibility and did not induce any skin irritation. The optimized combination of the HFMN-DCT reservoir showed an ex vivo permeation profile of 83.275 ± 2.405%. Notably, the proposed system showed superior pharmacokinetic profiles in the in vivo investigation using male Wistar rats. Overall, this study highlights the potential of HFMN-DCT reservoir systems as a versatile platform for transdermal drug delivery applications.

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“…This outcome aligns with previous research findings. The cross-linked films exhibited a distinctively smooth surface with reduced porosity, corroborating the cross-linking process. , …”

Section: Resultssupporting

confidence: 58%

“…An acceleration voltage of 15 kV was used. This study was also performed using a PVA–PVP film as a comparison …”

Section: Methodsmentioning

confidence: 99%

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Application of Biomaterials in the Development of Hydrogel-Forming Microneedles Integrated with a Cyclodextrin Drug Reservoir for Improved Pharmacokinetic Profiles of Telmisartan

Enggi,

Sulistiawati,

Himawan

et al. 2024

ACS Biomater. Sci. Eng.

Self Cite

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“…DDSs mainly deliver macromolecular drugs such as proteins, polypeptides, nucleic acids, and cells and tissues. 74 Synthetic polymeric materials, such as polyethylene glycol, 75 polyethyleneimine, 76 and polyacrylic acid 77 are commonly used for DDSs due to their flexible structures and functions that can be tailored through different cross-linking methods, response mechanisms, and degradation behaviors based on specific demands. 78 Recently, hydrogel materials like poloxamer 407 and poloxamer 188 have also shown potential for application in the treatment of IBD due to their temperature sensitivity characteristics.…”

Section: Biomaterials Science Reviewmentioning

confidence: 99%

Advancements in hydrogel-based drug delivery systems for the treatment of inflammatory bowel disease: a review

Liu,

Huang,

et al. 2024

Biomater. Sci.

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“…Hydrogels can be classified based on their origin, such as natural hydrogels [57] (derived from natural polymers like collagen [138], alginate [139], chitosan [88]) or synthetic hydrogels [82] (created from synthetic polymers like polyethylene glycol [52], polyvinyl alcohol [85], polyacrylamide [80]). Hydrogels can be classified based on their polymer composition, such as homopolymer hydrogels [45], copolymer hydrogels [112], multipolymer hydrogels [140], and interpenetrating network hydrogels [141]. Hydrogels can be classified as cationic [142], anionic [86], or neutral based on the presence of charged groups in their polymer structure [143].…”

Section: Artificial Cartilagementioning

confidence: 99%

Novel polymer-based hydrogels of recent research in drug delivery for disease treatment related to SARS-CoV-2 virus

Hoc Thang,

Van Phuc,

Nhi

et al. 2024

Express Polym. Lett.

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The COVID-19 pandemic has presented an array of challenges and given rise to a spectrum of diseases and health issues [1]. Foremost among the challenges of the pandemic is the swift transmission of the SARS-CoV-2 virus [2]. Strategies to curb transmission encompass extensive vaccination campaigns [3], the implementation of public health measures like mask-wearing [4] and social distancing [4], and the promotion of hygiene practices such as frequent handwashing [5]. The SARS-CoV-2 virus, which causes COVID-19, primarily targets the respiratory system [6]. However, it can also precipitate various complications and impact other organs and bodily systems [7]. COVID-19, an abbreviation for Coronavirus Disease 2019, is the ailment brought about by the SARS-CoV-2 virus [8]. It manifests as a broad spectrum of symptoms, spanning from mild to severe respiratory ailments [9]. Common symptoms include fever, cough, shortness of breath, fatigue, loss of taste or smell, and body aches [10]. In severe instances, it can progress to pneumonia and acute

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Application of multipolymers system in the development of hydrogel-forming microneedle integrated with polyethylene glycol reservoir for transdermal delivery of albendazole

Cited by 23 publications

References 57 publications

Application of Biomaterials in the Development of Hydrogel-Forming Microneedles Integrated with a Cyclodextrin Drug Reservoir for Improved Pharmacokinetic Profiles of Telmisartan

Application of Biomaterials in the Development of Hydrogel-Forming Microneedles Integrated with a Cyclodextrin Drug Reservoir for Improved Pharmacokinetic Profiles of Telmisartan

Advancements in hydrogel-based drug delivery systems for the treatment of inflammatory bowel disease: a review

Novel polymer-based hydrogels of recent research in drug delivery for disease treatment related to SARS-CoV-2 virus

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