2023
DOI: 10.1007/s40820-023-01125-2
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Application of Nano-Delivery Systems in Lymph Nodes for Tumor Immunotherapy

Abstract: Immunotherapy has become a promising research “hotspot” in cancer treatment. “Soldier” immune cells are not uniform throughout the body; they accumulate mostly in the immune organs such as the spleen and lymph nodes (LNs), etc. The unique structure of LNs provides the microenvironment suitable for the survival, activation, and proliferation of multiple types of immune cells. LNs play an important role in both the initiation of adaptive immunity and the generation of durable anti-tumor responses. Antigens taken… Show more

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Cited by 32 publications
(9 citation statements)
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“…34,[78][79][80][81] Targeted delivery systems have emerged as a game-changer in the field of immunotherapy, offering a multitude of advantages. 17,82,83 One of the key benefits is the enhancement of the therapeutic index, a measure of a drug's safety in relation to its effectiveness. 84,85 By increasing drug concentrations specifically at the tumor site and reducing off-target effects, targeted delivery systems can significantly improve this index.…”
Section: Investigating Targeted Delivery Systems For Immunotherapymentioning
confidence: 99%
See 1 more Smart Citation
“…34,[78][79][80][81] Targeted delivery systems have emerged as a game-changer in the field of immunotherapy, offering a multitude of advantages. 17,82,83 One of the key benefits is the enhancement of the therapeutic index, a measure of a drug's safety in relation to its effectiveness. 84,85 By increasing drug concentrations specifically at the tumor site and reducing off-target effects, targeted delivery systems can significantly improve this index.…”
Section: Investigating Targeted Delivery Systems For Immunotherapymentioning
confidence: 99%
“…84,85 By increasing drug concentrations specifically at the tumor site and reducing off-target effects, targeted delivery systems can significantly improve this index. 17,82,83 Moreover, these systems pave the way for the administration of lower drug doses. This approach not only minimizes systemic toxicity but also improves patient tolerability, striking a balance between efficacy and safety.…”
Section: Investigating Targeted Delivery Systems For Immunotherapymentioning
confidence: 99%
“…This can be achieved through the use of nanoparticle (NP)-based drug delivery systems that can selectively target cancer cells. [47,51,52] In addition, combination therapies involving MLT and other anticancer agents such as chemotherapy drugs or radiotherapy and using genetic engineering techniques to create MLT-producing cells have also been explored as a way to enhance the therapeutic efficacy of MLT while reducing its toxicity to healthy cells. [53,54] This review aims to underline the MLT properties and applications.…”
Section: Introductionmentioning
confidence: 99%
“…The field of nanomedicine has witnessed rapid advancements via the development of sophisticated nanomaterials and a deeper understanding of tumor pathogenesis. The application of nanomaterials in tumor therapy is garnering increased attention [4,5]. Rationally designed nanomaterials can significantly improve the stability of drugs in complex physiological environments and their accumulation at tumor sites by increasing permeability and retention efficacy [6][7][8].…”
Section: Introductionmentioning
confidence: 99%