Application of Nanocluster Iron–molybdene Polyoxometalates for Correction of Experimental Posthemorrhagic Anemia

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

“…The amount of molybdenum found in the blood 1 day after the administration of Keplerate POMs was proportional to the amount of the injected nanomaterial. A significant decrease in the level of molybdenum in the blood after 1 day compared to the content of the microelement one hour after intramuscular injection, as well as the normalization of the indicator after daily injections of POM within 30 days, was consistent with previously obtained data on the absence of molybdenum accumulation [132,137,141]. The absence of molybdenum accumulation [133] in the liver, kidneys, skin, and bone tissue [138] is probably associated with the decomposition and accelerated excretion of the elements constituting POM, which contributes to the normalization of the studied parameters (glucose, aminotransferase, and alkaline phosphatase values) [138] by day 30, a change of which was recorded upon a single injection of POM.…”

“…An analysis of peripheral blood parameters [138,140] of animals allowed one to draw the conclusion that there was no anemia [141] in the group of animals that got Mo 132 injections, since no significant difference was found in the number of erythrocytes, concentration of hemoglobin, the content and concentration of hemoglobin in erythrocytes in the experimental and intact rats. The total leukocytes in animals that got Mo 132 injections also did not increase, which indicates the absence of a systemic inflammatory process.…”

“…An analysis of red blood parameters in rats injected with Mo 72 Fe 30 yielded a conclusion that there was no anemia -a sign characteristic of many chronic intoxications, since the content of hemoglobin in erythrocytes of experimental rats did not decrease, but increased, on the contrary [108,139,142]. Moreover, the experimentally revealed effect of rapid recovery of the hemoglobin level in animals after modeling the post-hemorrhagic anemia [141] is interesting from the point of view of the possible use of POMs in treatment and prevention of iron deficiency anemia, which is confirmed by a patent [142]. The presence of molybdenum in the preparation does not prevent an increase in its effectiveness; besides, molybdenum is effectively removed from the body.…”

The Electrostatic‐Mediated Formation of a Coordination Complex: the Trapping and Release of an Antitumor Drug with an Anthracycline Core from {Mo72Fe30}‐Based Ensembles

“…This removes the problem of POM excretion, an issue when using metal or metal oxide nanoparticles. Furthermore, {Mo 72 Fe 30 } nanoclusters are effective for treating posthemorrhagic anemia in laboratory animals [27] . Comprehensive studies on laboratory animals (rats) and cell cultures show that {Mo 72 Fe 30 } is not harmful to the organism, individual organs, and on the molecular‐cellular level [25,28] .…”

“…Furthermore, {Mo 72 Fe 30 } nanoclusters are effective for treating posthemorrhagic anemia in laboratory animals. [27] Comprehensive studies on laboratory animals (rats) and cell cultures show that {Mo 72 Fe 30 } is not harmful to the organism, individual organs, and on the molecular-cellular level. [25,28] In comparison with the other drug delivery systems (like liposomes, magnetic metaloxide nanoparticles, peptide backbone copolymer etc.)…”