In this paper, the performance of the evacuated tube solar collector is investigated theoretically by the TRNSYS program. The simulation is conducted during the winter of 14th February-2019 in Cairo -Egypt. In this simulation, water and Nanofluids are working fluids. The types of Nanofluids are CeO2/water, WO3/water and AL2O3/water. The simulation is conducted at0.015%, 0.025%, 0.035% and 0.045% (volume concentrations).The mass flux rate and tilt angle are 0.017 kg/s.m2and 45o; respectively. The results show that the collector has the highest performance using nanofluids at studied concentrations. At 12:00 PM, the highest useful energy gain can be obtained from CeO2/water Nanofluid at 0.045% concentration, while thermal efficiency is higher by 34.2% than water. The nanofluidWO3/water presents low performance than that of CeO2/water and AL2O3/water. The thermal efficiencies ofAL2O3/ water and WO3/ water Nanofluids are higher than water by 28.4% and 12.5%; respectively, at concentration of 0.045% and 12:00PM.