Application of nanogels as drug delivery systems in multicellular spheroid tumor model

Abdolahinia, Elaheh Dalir; Barati, Ghasem; Ranjbar-Navazi, Zahra; Kadkhoda, Jamileh; Islami, Mohammad Reza; Hashemzadeh, Nastaran; Dizaj, Solmaz Maleki; Sharifi, Simin

doi:10.1016/j.jddst.2022.103109

Cited by 28 publications

(14 citation statements)

References 157 publications

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“…Nanogels are known to be able to retain a large volume of water and for their high biocompatibility and low cytotoxicity, their ability to encapsulate a larger number of drugs, and their responsiveness toward various external and internal stimuli, such as pH, reducing agent, oxidizing agent, catalyst, and temperature. 188 Nanogels can be rendered "smart" by carefully choosing the right backbone and cross-linking polymers. There are various natural and synthetic polymers that can be used to synthesize nanogels.…”

Section: Polymer-based Ndds In Cancer Therapymentioning

confidence: 99%

“…Nanogels are hydrogel particles formed by cross-linking of a polymeric network by either physical or chemical interaction. Nanogels are known to be able to retain a large volume of water and for their high biocompatibility and low cytotoxicity, their ability to encapsulate a larger number of drugs, and their responsiveness toward various external and internal stimuli, such as pH, reducing agent, oxidizing agent, catalyst, and temperature . Nanogels can be rendered “smart” by carefully choosing the right backbone and cross-linking polymers.…”

Section: Polymer-based Ndds In Cancer Therapymentioning

confidence: 99%

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Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Khan

Hossain

et al. 2022

ACS Appl. Bio Mater.

209

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Traditional treatment approaches for cancer involve intravenous chemotherapy or other forms of drug delivery. These therapeutic measures suffer from several limitations such as nonspecific targeting, poor biodistribution, and buildup of drug resistances. However, significant technological advancements have been made in terms of superior modes of drug delivery over the last few decades. Technical capability in analyzing the molecular mechanisms of tumor biology, nanotechnologyparticularly the development of biocompatible nanoparticles, surface modification techniques, microelectronics, and material scienceshas increased. As a result, a significant number of nanostructured carriers that can deliver drugs to specific cancerous sites with high efficiency have been developed. This particular maneuver that enables the introduction of a therapeutic nanostructured substance in the body by controlling the rate, time, and place is defined as the nanostructured drug delivery system (NDDS). Because of their versatility and ability to incorporate features such as specific targeting, water solubility, stability, biocompatibility, degradability, and ability to reverse drug resistance, they have attracted the interest of the scientific community, in general, and nanotechnologists as well as biomedical scientists. To keep pace with the rapid advancement of nanotechnology, specific technical aspects of the recent NDDSs and their prospects need to be reported coherently. To address these ongoing issues, this review article provides an overview of different NDDSs such as lipids, polymers, and inorganic nanoparticles. In addition, this review also reports the challenges of current NDDSs and points out the prospective research directions of these nanocarriers. From our focused review, we conclude that still now the most advanced and potent field of application for NDDSs is lipid-based, while other significantly potential fields include polymer-based and inorganic NDDSs. However, despite the promises, challenges remain in practical implementations of such NDDSs in terms of dosage and stability, and caution should be exercised regarding biocompatibility of materials. Considering these aspects objectively, this review on NDDSs will be particularly of interest for small-to-large scale industrial researchers and academicians with expertise in drug delivery, cancer research, and nanotechnology.

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Section: Polymer-based Ndds In Cancer Therapymentioning

confidence: 99%

Section: Polymer-based Ndds In Cancer Therapymentioning

confidence: 99%

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Khan

Hossain

et al. 2022

ACS Appl. Bio Mater.

209

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“…At present, the design of antitumor drugs is based on their selective targeting of cancer cells. Chemotherapy is a conventional treatment method; however, it is limited by its numerous adverse health side effects [ 12 , 13 ]. The side effects of chemotherapy are associated with acute and late toxicity.…”

Section: Introductionmentioning

confidence: 99%

Effect of Curcumin-Loaded Mesoporous Silica Nanoparticles on the Head and Neck Cancer Cell Line, HN5

Sharifi

Abdolahinia

Ghavimi

et al. 2022

CIMB

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Curcumin is an active ingredient isolated from Curcuma longa. It has several pharmacological effects, including anticancer, anti-inflammatory, and antioxidant effects. Due to its low bioavailability, chemical structure instability, and easy oxidation, the application of curcumin has been limited. In this study, to overcome these limitations, curcumin-loaded mesoporous silica nanoparticles (Cur-MSN) were prepared, and the anticancerous effect of Cur-MSNs on head and neck cancer cells, HN5, was investigated. Transmission electron microscopy (TEM) revealed rod-shaped mesoporous nanoparticles with average particle size smaller than 100 nm. Higher cytotoxicity of Cur-MSNs was seen in treated cancer cells compared with free curcumin. The expression of Bcl-2 was significantly reduced in the presence of Cur-MSNs compared to the control (untreated HN5 cells) (p < 0.05). A 3.43-fold increase in the Bax/Bcl-2 ratio was seen in Cur-MSNs treated HN5 cells at the IC50. Cur-MSNs increased intracellular reactive oxygen species (ROS) production. Based on these novel results, we suggest that Cur-MSNs offer efficacy for cancer treatment and future studies should further characterize their properties in various experimental cancer models.

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“…According to Soni et al (2016) , “nanogels are three-dimensional hydrogel materials in the nanoscale size range formed by cross-linked swell-able polymer networks with a high capacity to hold water, without actually dissolving into the aqueous medium.” Nanogels possess the combined characteristics of nanoparticles and hydrogels, and their size ranges from 20 to 200 nm ( Jain et al, 2019 ; Abdolahinia et al, 2022 ). The gel feature of nanogels enables them swell when in contact with physiological fluids.…”

Section: Nanogels For Cancer Therapymentioning

confidence: 99%

Nanogels as target drug delivery systems in cancer therapy: A review of the last decade

et al. 2022

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Cancer is an important cause of morbidity and mortality worldwide, irrespective of the level of human development. Globally, it was estimated that there were 19.3 million new cases of cancer and almost 10 million deaths from cancer in 2020. The importance of prevention, early detection as well as effective cancer therapies cannot be over-emphasized. One of the important strategies in cancer therapy is targeted drug delivery to the specific tumor sites. Nanogels are among the several drug delivery systems (DDS) being explored as potential candidates for targeted drug delivery in cancer therapy. Nanogels, which are new generation, versatile DDS with the possession of dual characteristics of hydrogels and nanoparticles have shown great potential as targeted DDS in cancer therapy. Nanogels are hydrogels with a three-dimensional (3D) tunable porous structure and a particle size in the nanometre range, from 20 to 200 nm. They have been visualized as ideal DDS with enormous drug loading capacity, and high stability. Nanogels can be modified to achieve active targeting and enhance drug accumulation in disease sites. They can be designed to be stimulus-responsive, and react to internal or external stimuli such as pH, temperature, light, redox, thus resulting in the controlled release of loaded drug. This prevents drug accumulation in non-target tissues and minimizes the side effects of the drug. Drugs with severe adverse effects, short circulation half-life, and easy degradability by enzymes, such as anti-cancer drugs, and proteins, are suitable for delivery by chemically cross-linked or physically assembled nanogel systems. This systematic review summarizes the evolution of nanogels for targeted drug delivery for cancer therapy over the last decade. On-going clinical trials and recent applications of nanogels as targeted DDS for cancer therapy will be discussed in detail. The review will be concluded with discussions on safety and regulatory considerations as well as future research prospects of nanogel-targeted drug delivery for cancer therapy.

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Application of nanogels as drug delivery systems in multicellular spheroid tumor model

Cited by 28 publications

References 157 publications

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Effect of Curcumin-Loaded Mesoporous Silica Nanoparticles on the Head and Neck Cancer Cell Line, HN5

Nanogels as target drug delivery systems in cancer therapy: A review of the last decade

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