Application of Nanohydrogels in Drug Delivery Systems: Recent Patents Review

Dalwadi, Chintan; Patel, Grishma

doi:10.2174/1872210509666150101151521

Cited by 51 publications

(31 citation statements)

References 52 publications

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“…Additionally, an injectable hydrogel can accommodate cellular and molecular therapeutics to modulate the wound environment46 and enhance regeneration40. Hydrogels are a water-swollen insoluble polymer 3D network that have a wide range of chemical compositions and properties474849. Conventional hydrogels are not suitable for encapsulating growth factors for SCI treatment because of their poor affinity for the growth factors and their poorly tuneable mechanical strength at normal body temperature.…”

Section: Discussionmentioning

confidence: 99%

Thermo-sensitive hydrogels combined with decellularised matrix deliver bFGF for the functional recovery of rats after a spinal cord injury

Tian

et al. 2016

Sci Rep

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Because of the short half-life, either systemic or local administration of bFGF shows significant drawbacks to spinal injury. In this study, an acellular spinal cord scaffold (ASC) was encapsulated in a thermo-sensitive hydrogel to overcome these limitations. The ASC was firstly prepared from the spinal cord of healthy rats and characterized by scanning electronic microscopy and immunohistochemical staining. bFGF could specifically complex with the ASC scaffold via electrostatic or receptor-mediated interactions. The bFGF-ASC complex was further encapsulated into a heparin modified poloxamer (HP) solution to prepare atemperature-sensitive hydrogel (bFGF-ASC-HP). bFGF release from the ASC-HP hydrogel was more slower than that from the bFGF-ASC complex alone. An in vitro cell survival study showed that the bFGF-ASC-HP hydrogel could more effectively promote the proliferation of PC12 cells than a bFGF solution, with an approximate 50% increase in the cell survival rate within 24 h (P < 0.05). Compared with the bFGF solution, bFGF-ASC-HP hydrogel displayed enhanced inhibition of glial scars and obviously improved the functional recovery of the SCI model rat through regeneration of nerve axons and the differentiation of the neural stem cells. In summary, an ASC-HP hydrogel might be a promising carrier to deliver bFGF to an injured spinal cord.

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Section: Discussionmentioning

confidence: 99%

Thermo-sensitive hydrogels combined with decellularised matrix deliver bFGF for the functional recovery of rats after a spinal cord injury

Tian

et al. 2016

Sci Rep

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“…Nanohydrogels have grabbed great attention since that they can act as unique controlled drug delivery systems, biological sensors, absorbents and biomimetic structures [18]. Nanohydrol can be developed using either natural or synthetic polymers for the abovementioned applications [19].…”

Section: Nanotechnologymentioning

confidence: 99%

Hyaluronic acid hydrogel nanoscaffolds: production and assessment of the physicochemical properties

Ahmadian

Maleki

Sharifi

et al. 2020

Eurasian Chem. Commun.

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Hyaluronic acid (HA) is the major constituent of the extracellular matrix (ECM) and mainly acts as a filler in the connective tissues. The goal of the current study was to develop and evaluate the physiochemical properties of HA hydrogel nanoscaffolds. Chemical precipitation technique and the use of glutaraldehyde-based crosslinking were utilized to prepare the nanoscaffolds. Dynamic light scattering (DLS), zeta sizer (measurement of zeta potential), scanning electron microscopy (SEM), and fourier transform infrared spectroscopy (FTIR) were performed to characterize the produced HA hydrogel nanoscaffolds. A relatively bimodal and monodispersed HA nanohydrogels were obtained and the mean particle size was reported to be 291.30 nm. In addition, the results showed that zeta potential had a negative value (-5.96 mv). The FTIR results proved the crosslinking of the constructed scaffold. The observed physiochemical specifications proposed that HA hydrogel nanoscaffolds could hold promise in different biomedical implementations, in particular, tissue regeneration.

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“…Nanotechnology, the engineering and manufacturing of materials at the atomic and molecular scale, has had an impact on pharmaceutical technology (Farokhzad and Langer, 2009). Since nanoparticle formulations appeared in the 1970s (Gregoriadis, 1978;Couvreur et al, 1977), various nanostructures, such as dendrimers (Cheng et al, 2008), nanohydrogels (Dalwadi and Patel, 2015), nanoemulsions (Sarker, 2005), nanoliposomes (Gregoriadis, 1978), and nanofibers (Hu et al, 2014), have been utilized for the development of new dosing formulations for pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

Potential of biocompatible polymeric ultra-thin films, nanosheets, as topical and transdermal drug delivery devices

Hatanaka

Saito

Fukushima

et al. 2019

International Journal of Pharmaceutics

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The aim of the present study was to assess the potential of biocompatible polymeric nanosheets as topical and transdermal drug-delivery devices. Nanosheets are two-dimensional nanostructures with a thickness in the nanometer order, and their extremely large aspect ratios result in unique properties, including high transparency, flexibility, and adhesiveness. Nanosheet formulations containing betamethasone valerate (BV) as a model drug and consisting of poly (L-lactic acid) or poly (lactic-co-glycolic) acid were fabricated through a spin-coating-assisted layer-by-layer method using a water-soluble sacrificial membrane. The fabricated formulations could incorporate and release higher amounts of BV compared with a commercial ointment, and the amounts could be controlled by the polymers used, the amount of BV added, and the use of controlled-release membranes. The presence of BV had a minimal effect on thickness, transparency, adhesiveness, and moisture permeability of nanosheets, permitting their application to any area of skin for a long period of time. Therefore, this biocompatible polymeric nanosheet formulation represents a novel and promising topical and transdermal drug delivery device, which has potential to deliver drugs regardless of the area of skin.

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Application of Nanohydrogels in Drug Delivery Systems: Recent Patents Review

Cited by 51 publications

References 52 publications

Thermo-sensitive hydrogels combined with decellularised matrix deliver bFGF for the functional recovery of rats after a spinal cord injury

Thermo-sensitive hydrogels combined with decellularised matrix deliver bFGF for the functional recovery of rats after a spinal cord injury

Hyaluronic acid hydrogel nanoscaffolds: production and assessment of the physicochemical properties

Potential of biocompatible polymeric ultra-thin films, nanosheets, as topical and transdermal drug delivery devices

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