Application of nanomedicine and mesenchymal stem cells in burn injuries for the elderly patients

Xiong, Wei; Zhang, Rui; Zhou, Heng; Liu, Ye; Liang, Ming; Li, Keshen; Duan, Xingxiang; Chen, David P.; Luo, Yu; Xu, Jia; Ai, Yilong; He, Yan; Ye, Qingsong

doi:10.1016/j.smaim.2022.08.001

Cited by 7 publications

(3 citation statements)

References 146 publications

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“…Studies have shown that liposomes, particularly nanoliposomes with size of around 150 nm, can penetrate deeper into the skin layers, which is beneficial for the treatment of severe burn wounds that extend beyond the epidermis into the dermis and hypodermis (El Maghraby et al., 2008 ). Furthermore, liposomes create a moist microenvironment at the wound site, promoting improved wound healing (Hussain et al., 2022 ; Xiong et al., 2023 ). In a study, asiaticoside (AS), a triterpenoid saponin derived from Centella asiatica , known for its anti-inflammatory and antioxidant properties was encapsulated into liposomes (LIP) to create asiaticoside-loaded liposomes (LIP@AS) with an average size of 121.10 ± 2.40 nm.…”

Section: Strategies To Enhance Transdermal Drug Delivery For Burn Wou...mentioning

confidence: 99%

Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system

Goh,

Du,

Peng

et al. 2024

Drug Delivery

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Burn injuries are prevalent and life-threatening forms that contribute significantly to mortality rates due to associated wound infections. The management of burn wounds presents substantial challenges. Hydrogel exhibits tremendous potential as an ideal alternative to traditional wound dressings such as gauze. This is primarily attributed to its three-dimensional (3D) crosslinked polymer network, which possesses a high water content, fostering a moist environment that supports effective burn wound healing. Additionally, hydrogel facilitates the penetration of loaded therapeutic agents throughout the wound surface, combating burn wound pathogens through the hydration effect and thereby enhancing the healing process. However, the presence of eschar formation on burn wounds obstructs the passive diffusion of therapeutics, impairing the efficacy of hydrogel as a wound dressing, particularly in cases of severe burns involving deeper tissue damage. This review focuses on exploring the potential of hydrogel as a carrier for transdermal drug delivery in burn wound treatment. Furthermore, strategies aimed at enhancing the transdermal delivery of therapeutic agents from hydrogel to optimize burn wound healing are also discussed.

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Section: Strategies To Enhance Transdermal Drug Delivery For Burn Wou...mentioning

confidence: 99%

Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system

Goh,

Du,

Peng

et al. 2024

Drug Delivery

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“…ADSCs diminish pro-inflammatory factors like tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) while increasing anti-inflammatory ones like interleukin-4 (IL-4) and interleukin-10 (IL-10) [ 163 ]. Systematically infused BMMSCs migrate to local wound sites, interact with the inflammatory microenvironment, and induce macrophage polarization toward the M2 phenotype [ 164 , 165 ]. ADSCs regulate cytokines by suppressing T-lymphocyte activation and B-lymphocyte apoptosis [ 166 ].…”

Section: The Effect and Possible Mechanism Of Mscs In Improving Wound...mentioning

confidence: 99%

Insights into the role of mesenchymal stem cells in cutaneous medical aesthetics: from basics to clinics

Li,

Liu,

Zhang

et al. 2024

Stem Cell Res Ther

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With the development of the economy and the increasing prevalence of skin problems, cutaneous medical aesthetics are gaining more and more attention. Skin disorders like poor wound healing, aging, and pigmentation have an impact not only on appearance but also on patients with physical and psychological issues, and even impose a significant financial burden on families and society. However, due to the complexities of its occurrence, present treatment options cannot produce optimal outcomes, indicating a dire need for new and effective treatments. Mesenchymal stem cells (MSCs) and their secretomics treatment is a new regenerative medicine therapy that promotes and regulates endogenous stem cell populations and/or replenishes cell pools to achieve tissue homeostasis and regeneration. It has demonstrated remarkable advantages in several skin-related in vivo and in vitro investigations, aiding in the improvement of skin conditions and the promotion of skin aesthetics. As a result, this review gives a complete description of recent scientific breakthroughs in MSCs for skin aesthetics and the limitations of their clinical applications, aiming to provide new ideas for future research and clinical transformation.

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“…A significant aspect of such techniques is the use of mesenchymal stem cells (hereinafter referred to as MSCs). According to recent studies, MSCs demonstrate high effectiveness in wound healing, not only due to their proliferative activity but also to their paracrine immunomodulatory effects and stimulation of the reparative processes ( 9 - 11 ).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and Safety of Transplantation of the Stromal Vascular Fraction of Autologous Adipose Tissue for Wound Healing in the Donor Site in Patients with Third-Degree Skin Burns: A Randomized Trial

Ryabkov,

Egorikhina,

Koloshein

et al. 2023

MJIRI

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Background The quality of the wound healing at the donor site significantly determines the overall condition of the burn patient, the extent of wound fluid and protein losses, the severity of any systemic in-flammatory reaction, and the intensity of the pain syndrome. It is known that the stromal vas-cular fraction (SVF) has a beneficial effect on the healing of wound defects. This study is aimed at assessing the safety and effectiveness of the application of the SVF of autologous adipose tis-sue to stimulate wound healing of the donor site in patients with burns. Methods This placebo-controlled clinical study included 38 patients with third-degree thermal skin burns. The patients underwent liposuction, enzymatic isolation of the SVF, and intradermal injection of the preparation into the wounds in the donor site, followed by tewametry, cutome-try, thermography and biopsy after 12 days. Quantitative indicators were compared using the Mann-Whitney test for unrelated groups and the Wilcoxon test for related groups. Spearman's rank correlation coefficient (RS) was used to assess the correlation Results Epithelization of the wounds in all patients was seen over an average area of 88 (84;92) %, there being no significant differences between the actual and the control wound sites for this parameter. Transdermal water loss in the test wound sites was 2 times lower than in the control sites ( P = 0.001). The wound donor sites regained their temperature distribution faster than the control sites ( P = 0.042). Histological preparations of the skin of the wound sites revealed that their epidermal layer was 19% thicker compared to the controls ( P = 0.043). It should be noted that five adverse events related to manipulations in the postoperative period were registered. Conclusion Transplantation of SVF autologous adipose tissue into the wound area in most clinical cases proceeded without complications. The area of epithelialization of wound areas af-ter the introduction of SVF did not change, although a significant decrease in transdermal water loss was observed in the wound areas with an improvement in their thermoregulation and an increase in the thickness of the epidermis.

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Application of nanomedicine and mesenchymal stem cells in burn injuries for the elderly patients

Cited by 7 publications

References 146 publications

Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system

Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system

Insights into the role of mesenchymal stem cells in cutaneous medical aesthetics: from basics to clinics

Effectiveness and Safety of Transplantation of the Stromal Vascular Fraction of Autologous Adipose Tissue for Wound Healing in the Donor Site in Patients with Third-Degree Skin Burns: A Randomized Trial

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