Application of Nanoparticles in Human Nutrition: A Review

Altemimi, Ammar B.; Farag, Halgord Ali M.; Salih, Tablo H.; Awlqadr, Farhang H.; Al-Manhel, Alaa Jabbar Abd; Vieira, Italo Rennan Sousa; Conte-Junior, Carlos Adam

doi:10.3390/nu16050636

Cited by 12 publications

(1 citation statement)

References 136 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to studying ways to increase the bioavailability of phenolic compounds, future studies should look for a food source that guarantees the adequate absorption of natural plant polyphenols. To improve the bioavailability and effectiveness of polyphenols, various drug delivery systems have recently been studied, with encouraging outcomes [ 272 , 273 , 274 ]. These systems include lipid-based carriers, polymer nanoparticles, and conjugate-based systems.…”

Section: Future Challenges and Restrictionsmentioning

confidence: 99%

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

Farhan,

Rizvi,

Aatif

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

Given the ongoing rise in the occurrence of allergic disorders, alterations in dietary patterns have been proposed as a possible factor contributing to the emergence and progression of these conditions. Currently, there is a significant focus on the development of dietary therapies that utilize natural compounds possessing anti-allergy properties. Dietary polyphenols and plant metabolites have been intensively researched due to their well-documented anti-inflammatory, antioxidant, and immunomodulatory characteristics, making them one of the most prominent natural bioactive chemicals. This study seeks to discuss the in-depth mechanisms by which these molecules may exert anti-allergic effects, namely through their capacity to diminish the allergenicity of proteins, modulate immune responses, and modify the composition of the gut microbiota. However, further investigation is required to fully understand these effects. This paper examines the existing evidence from experimental and clinical studies that supports the idea that different polyphenols, such as catechins, resveratrol, curcumin, quercetin, and others, can reduce allergic inflammation, relieve symptoms of food allergy, asthma, atopic dermatitis, and allergic rhinitis, and prevent the progression of the allergic immune response. In summary, dietary polyphenols and plant metabolites possess significant anti-allergic properties and can be utilized for developing both preventative and therapeutic strategies for targeting allergic conditions. The paper also discusses the constraints in investigating and broad usage of polyphenols, as well as potential avenues for future research.

show abstract

Section: Future Challenges and Restrictionsmentioning

confidence: 99%

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

Farhan,

Rizvi,

Aatif

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

Nanominerals Packaged in pH‐Responsive Alginate Microcapsules Exhibit Selective Delivery in Small Intestine and Enhanced Absorption and Bioavailability

Bhagat,

Singh

2024

Adv Funct Materials

View full text Add to dashboard Cite

Mineral supplementation is crucial for human nutrition to facilitate appropriate growth, disease prevention, and improved reproductive health. The conventional forms of mineral supplementation involve an ionic form of elements mixed with biomolecules; however, suffer from unfavorable reactions under an acidic environment of stomach, ROS generation, and poor absorption in the small intestine. To address this, nanominerals (NMs) of six essential mineral elements are synthesized and packed in pH‐responsive microcapsule. Each NMs is coated with biomolecules that are known to rapidly absorb through the intestinal epithelium. Microcapsules are found intact at acidic pH (pH: 2.0–6.5); however, selectively release NMs at pH ≥7.0. The in vitro study demonstrates that the mixture of NMs and microcapsules is biocompatible and exhibits excellent ROS scavenging ability at physiological pH. Oral administration of NMs‐loaded microcapsules to rats shows enhanced levels of minerals, vitamin B12, hemoglobin, and total antioxidant activity in blood. The liver, kidneys, and spleen show enhanced expression of Cu/Zn‐SOD and Mn‐SOD enzymes due to high absorption and bioavailability of ZnO, Cu2O, and MnO2 NMs through the intestine. Thus, the pH‐responsive microcapsules hold promise to effectively stealth the encapsulated nutrient materials from the acidic environment of stomach and precisely deliver them to small intestine.

show abstract

Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection

Safaran,

Javadi,

Pourmadadi

et al. 2024

J Nanopart Res

View full text Add to dashboard Cite

This review examines the latest developments in nanoscopic antibiotic formulations used to treat infections caused by bacteria. A wide range of nanocarrier platforms are discussed, including polymer-based nanoparticles (NPs), lipid-based vesicles, mesoporous silica, and other inorganic materials. The antibiotic levofloxacin (LVF) is predominantly used as a model drug given its broad-spectrum activity. Studies in this regard have evaluated drug loading and encapsulation efficiency (EE) using analytical techniques such as FTIR, DLS, and TEM. In vitro release kinetics was characterized through dialysis and fluorescence-based assays. Zone of inhibition and viability studies provided insights into antibacterial efficacy. Some approaches incorporated stimuli-responsive polymers or targeting ligands to facilitate controlled or targeted drug release. Overall, the nanocarriers demonstrated potential for sustained antibiotic levels, reduced dosing, and improved treatment of biofilms and intracellular infections compared to free drug administration. The review offers a comprehensive analysis of this promising field with implications for combating antibiotic resistance.

show abstract

Application of Nanoparticles in Human Nutrition: A Review

Cited by 12 publications

References 136 publications

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

Nanominerals Packaged in pH‐Responsive Alginate Microcapsules Exhibit Selective Delivery in Small Intestine and Enhanced Absorption and Bioavailability

Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection

Contact Info

Product

Resources

About