Application of near-infrared spectroscopy for the rapid analysis ofLonicerae Japonicae Flossolution extracted by water

Xue, Xiao; Ma, Jinfang; Ge, Fahuan; Zhang, Xiangdong; Yang, Huihua; Liang, Qionglin; Wang, Yiming; Luo, Guoan

doi:10.1142/s1793545813500636

Cited by 10 publications

(5 citation statements)

References 17 publications

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“…Numerous papers have been published in qualitative and quantitative analysis of CQAs in plants by liquid chromatography (LC) coupled with spectroscopic detection techniques, such as ultraviolet (UV), fluorescence (FL) nuclear magnetic resonance (NMR) and mass spectroscopy (MS), and even near-infrared (NIR) spectroscopy [56,61,62,84,86,87,89,[92][93][94][95][96][97][98][99]. It is worth to add that nowadays the coupling of separation and detection techniques can involve more than one separation or detection techniques, e.g.…”

Section: Chromatographic Analysismentioning

confidence: 99%

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Chlorogenic acids – their properties, occurrence and analysis

Gil

Wianowska

2017

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Chlorogenic acids (CQAs), the esters of caffeic acid and quinic acid, are biologically important phenolic compounds present in many plant species. Nowadays much is known from their pro-health properties, including anti-cancer activity. Yet, the supposition that they may be helpful in fighting obesity and modify glucose-6-phosphatase involved in glucose metabolism have led to a revival of research on CQAs properties and their natural occurrence. Much attention is also paid to the proper analysis of CQAs content in plants and plant products due to the fact that the main CQAs representative in nature i.e. 5-O-caffeoylquinic acid (5-CQA) is commonly employed as a quality marker in the control of various natural products.The common procedures used so far for CQAs determination in plants involve conventional long lasting solvent extraction realized at higher temperatures prior to chromatographic analysis. The drawbacks associated to the conventional extraction techniques have led to the search for new alternative extraction processes that additionally could improve extracts quality. The latter is particularly important as regards CQAs applications, and the fact that these compounds easily transform/degrade to others. According to reports, the conventional heating of 5-CQA in the presence of water causes its isomerization and transformation. The reports prove that 5-CQA not only isomerizes to 3- and 4-O-caffeoylquinic acid, but also undergoes other transformations such as esterification and reactions with water. Hence, in the attempt to improve the process of chlorogenic acids extraction and to make it more effective and environmentally friendly, innovative so-called "enhanced" techniques of extraction have been recently developed and applied. To guarantee the proper analysis of compounds with very similar properties forming the chlorogenic acids family and their numerous transformation/degradation products, hyphenated techniques, in particular LC-MS, are currently being used.

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Section: Chromatographic Analysismentioning

confidence: 99%

“…Xiao et al [96] developed a rapid quantitative analytical method for the determination of three components (secologanic acid, chlorogenic acid and galuteolin) in the Lonicerae Japonicae Flos extracts using nearinfrared (NIR) spectroscopy. The concentrations of analytes were determined by using HPLC-DAD as the reference method.…”

Section: Chromatographic Analysismentioning

confidence: 99%

Chlorogenic acids – their properties, occurrence and analysis

Gil

Wianowska

2017

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“…Processes of spectral wavebands selection, spectral pretreatment, and PLS modeling were performed using THUNIR software (Tsinghua University version 3.0, Beijing) [26][27][28][29].…”

Section: Methodsmentioning

confidence: 99%

An Approach to Rapid Determination of Tween-80 for the Quality Control of Traditional Chinese Medicine Injection by Partial Least Squares Regression in Near-Infrared Spectral Modeling

Chen

Zhang³

et al. 2019

Journal of Spectroscopy

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This study established an approach to rapidly determine the Tween-80 in traditional Chinese medicine (TCM) injection by using near-infrared (NIR) spectroscopy. Totally 133 standard solutions of Tween-80 were prepared and randomly divided into calibration set and validation set, containing 109 and 24 samples, respectively. Spectral data were preprocessed and then subjected to establish a predictive model using partial least-squares (PLS). The standard error of cross validation (SECV), standard deviation of calibration (SEC), and the determination coefficient (R) of the established model were 0.0561, 0.0526, and 0.9986, respectively. The model was successfully applied to determine Tween-80 contents in 25 XBJ Injections and 40 FFSX Injections, and it produced satisfactory quantitative analysis results with average relative deviations 0.60% and 0.16%, respectively, for 25 XBJ Injections and 40 FFSX Injections, and the maximum relative deviations 8.57% and 7.60%, respectively. This work shows that NIR model displayed quite good predictive ability for Tween-80 quantitative analysis, which could potentially be applied to rapid determination of Tween-80 in the production process of TCM injections and other TCM products.

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“…Following such initiative, various spectroscopic (UV/vis, IR, and Raman) and chromatographic methods for process monitoring have been developed. Among these methods, nearinfrared (NIR) spectroscopy is the most widely used in the pharmaceutical industry, [16][17][18][19] mainly owing to its rapid turnaround (in seconds or minutes), nondestructive nature, high sensitivity, and minimal or no sample preparation. 20 NIR spectroscopy, a type of vibration spectroscopy, has a wavelength range of 700-2500 nm (14,300-4000 cm À1 Þ.…”

Section: Introductionmentioning

confidence: 99%

In-situ monitoring of saccharides removal of alcohol precipitation using near-infrared spectroscopy

Huang

2018

J. Innov. Opt. Health Sci.

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As unsafe components in herbal medicine (HM), saccharides can a®ect not only the drug appearance and stabilization, but also the drug e±cacy and safety. The present study focuses on the in-line monitoring of batch alcohol precipitation processes for saccharide removal using nearinfrared (NIR) spectroscopy. NIR spectra in the 4000-10,000-cm À1 wavelength range are acquired in situ using a trans°ectance probe. These directly acquired spectra allow characterization of the dynamic variation tendency of saccharides during alcohol precipitation. Calibration models based on partial least squares (PLS) regression have been developed for the three saccharide impurities, namely glucose, fructose, and sucrose. Model errors are estimated as the root-meansquare errors of cross-validation (RMSECVs) of internal validation and root-mean-square errors of prediction (RMSEPs) of external validation. The RMSECV values of glucose, fructose, and sucrose were 1.150, 1.535, and 3.067 mgÁmL À1 , and the RMSEP values were 0.711, 1.547, and 3.740 mg Á mL À1 , respectively. The correlation coe±cients (rÞ between the NIR predictive and the reference measurement values were all above 0.94. Furthermore, NIR predictions based on the constructed models improved our understanding of sugar removal and helped develop a control strategy for alcohol precipitation. The results demonstrate that, as an alternative process analytical technology (PAT) tool for monitoring batch alcohol precipitation processes, NIR spectroscopy is advantageous for both e±cient determination of quality characteristics (fast, in situ, and requiring no toxic reagents) and process stability, and evaluating the repeatability.

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Application of near-infrared spectroscopy for the rapid analysis ofLonicerae Japonicae Flossolution extracted by water

Cited by 10 publications

References 17 publications

Chlorogenic acids – their properties, occurrence and analysis

Chlorogenic acids – their properties, occurrence and analysis

An Approach to Rapid Determination of Tween-80 for the Quality Control of Traditional Chinese Medicine Injection by Partial Least Squares Regression in Near-Infrared Spectral Modeling

In-situ monitoring of saccharides removal of alcohol precipitation using near-infrared spectroscopy

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