Nowadays, aeronautics discovers new ways of flights near the critical regimes, unconventional aircraft forms, utilizing the micro-electro-mechanical technologies in flow and aircraft control, adaptive and morphing structures, using the structures and controls based on the biological principles, developing highly flexible structures, etc. Before deployment, these new technologies and solutions must be evaluated, tested in wide aerodynamic, flight dynamic simulations that require improved and new type of aerodynamic coefficient models. The chapter overviews the applicable models of the aerodynamic coefficients, introduces some new models and demonstrates how the different models can be applied in different goal-and object-oriented solutions. The following will be shortly explained: (i) how the aerodynamic forces and moments are generating, (ii) how the linear, nonlinear, steady, and nonsteady aerodynamic coefficient structures and forms might be modeled, and (iii) how to harmonize the model with the goal and object of investigations.